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Summary Expression Gene Literature (16) GO Terms (12) Nucleotides (188) Proteins (30) Interactants (63) Wiki
XB-GENEPAGE-996082
Gene Symbol:
scnn1a

Gene Name:
sodium channel, non voltage gated 1 alpha subunit

Synonyms:
alpha-ENaC , besc2 , enaca , scnea , scnn1 , ENaCalpha ( Add synonyms , Nomenclature history )

Gene Function:
Non voltage-gated ion channels (DEG/ENaC family)

Protein Function :
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical mem...[+]



Interactants:
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Diseases: 


Disease Ontology:
autosomal recessive pseudohypoaldosteronism type 1 [+]

OMIM:
PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL RECESSIVE; PHA1B [+]

External Links:
 
Xenbase Gene ID XB-GENE-996083 XB-GENE-996110 XB-GENE-17331371
Gene Symbol scnn1a scnn1a.L scnn1a.S
Chromosome Chr07 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 395013
397811
108697352
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine scnn1a scnn1a.L scnn1a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SCNN1A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Scnn1a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Scnn1a Ensembl
zebrafish
chicken
GEISHA SCNN1A Ensembl
fruit fly
worm
Publications
First Alternatively spliced forms of the alpha subunit of the epithelial sodium channel: distinct sites for amiloride binding and channel pore., Mol Pharmacol 1995  
Most Recent Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC., J Steroid Biochem Mol Biol 2010  
All View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 2 terms 11 terms 2 terms
PANTHER scnn1a
KEGG Pathways K04824 K04824 K04824
KOG [PT] Non voltage-gated ion channels (DEG/ENaC family)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks scnn1a
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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