ctsb Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (7)

Nucleotides (623)

Interactants (34)

XB-GENEPAGE-1000504

[provisional- machine annotated only] Gene Symbol: ctsb [Predicted: Source is Human Entrez Gene] Gene Name: cathepsin B [Predicted: Source is Human Entrez Gene] Synonyms: cathepsin B, apps, cpsb Add Xenopus synonyms Gene Function: Cysteine proteinase Cathepsin L Interactants: upk3a(2) , akt1(1) , anxa2(1) , app(1) , arhgef7(1) , atf5(1) , atf5.2(1) View All

XB-GENE-1000505

XB-GENE-6256351

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_203894\|Xenopus (Silurana) tropicalis cathepsin B (ctsb), mRNA GTGAGTGAGCAGCAGCCCTCAGGGGAGTCCTGCAACAATGTGGCAGCCTGTAGTCGTACTCTGCTTCCTGGCCTCCATTGCCAGCGCCCGGCATCTCCCCTTCTTTGCCCCCTTGTCTGGTGATATGGTGAATTATATCAACAAGATGAACACTACATGGAAGGCTGGGCACAACTTTGCTAATGCAGATCTACACTATGTAAAACGACTCTGTGGAACACACCTTAACGGCCCCCAGCTGCAGAAGAGGTTTGGCTTCGCTGACGGCATGGAGCTTCCAGACAGCTTTGATTCGCGGGCAGCCTGGCCCAACTGTCCCACCATTAGGGAGGTCAGAGATCAGGGATCCTGCGGCTCTTGCTGGGCGTTTGGTGCAGTGGAAGCCATCTCTGACCGTGTTTGTGTGCACACCAATGGGAAGGTGAATGTGGAGGTGTCTGCGGAAGATCTCCTGTCCTGCTGTGGCTTTGAATGTGGCATGGGCTGTAACGGAGGGTACCCATCTGGAGCCTGGAAATTCTGGACTGAGACCGGTCTGGTTTCTGGGGGCCTGTACGACTCCCACTTGGGCTGCCGGCCCTACTCCATCCCTCCCTGTGAGCACCATGTGAATGGATCAAGGCCGGCCTGCAAGGGGGAAGAGGGCGATACCCCAAAGTGTGTGAAGCAGTGCGAGGATGGCTACGCTCCAGTCTATGGCAGTGACAAACACTTCGGAGCGACCTCCTACGGCGTGCCAAGCAGTGAGAAGGAAATTATGGCTGAAATCTACAAGAACGGCCCAGTAGAGGGAGCTTTCTTGGTCTATGCCGACTTCCCAATGTACAAGTCAGGTGTGTACCAGCATGAAACCGGAGAAGAACTTGGAGGTCATGCTATTAAGATCCTGGGATGGGGTGTGGAAAATGGCACCCCCTATTGGCTGTGTGCAAACTCTTGGAACACTGATTGGGGTGATAATGGCTTCTTCAAGATTCTGCGTGGCAAGGATCACTGCGGGATCGAGTCTGAGATTGTTGCCGGAATTCCCAAAAACTAGAGCTTTTATCAATTTCTTTTAACTGACGCCTGCTACAATATGACCTTTTATTTAGAAAGAAGGAAAACAGAACAAAACTTTTTTTTTAATTCAAGTGTTATTAGTTTTACTAGGATATCTGAGTATAGGGGTAGTTGGCCAGGCTGGGGCTACTACTCTTTTAGAGCAGAGCAGGCTGGGAAACTATAGGGGGGGGGGGGGGGGTATCCTTGTTGCCCCAGTGAGCGCTGTACTGGCCCAGGGCTTGGCATGTAACTCTGCAGGTACTGCCTCTCCCAGGAACCCGCAGGGAGTTGGGTTAAACAATATCTGTTGCAAGTGGCCAATCCCTGAGCGAGACACAAGCCAATAGGAGCCCTGACCCCATACAATGTGACCAGATTTCTGTCTTTCATTCTGGGGGGAATCTCTACAGACTCCTCCCCCTGACTAATTAGGTTCCCATAGTTGTGATTGGCTCAATCATGCTGCCGATTAATTGGGGAATGTTCTGTAAACTGATCTATAGATATTCTGTTCTTATACACAAAGGGCACTGGGGTTGTTATACGGCTGGTACTGGCGTTTTACCCATAACCACTATATATACCGTGCCCATTGCTTCTGCTGGGAGTTGCCCTGAGGGGCATGAGTGCATTGCATGGCATGTAAATGGGCGGAGCTAGGGGGTAAATCCTTGTTGGATACCCACGTGCCACTTGTATACGCGCCTCACGTTGCCTTTTTTTAGTTCTTGTCTTTTAAAAAGATGGTAGTGTCAAGATTTTTTTTTTTTTTAAATTTGCCAATAAAATGCCTTGTCTTCCTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001086101\|Xenopus laevis cathepsin B (ctsb), mRNA GTGAGTGTGATTGAGCAGCAGCCCTCAGGGGAGTCCTGCAACAATGTGGCATCTTGTAGTTGCACTCTGCTTCTTGGCCTCCATCGCCAGCTCCCGGCATCTCCCCTACTTTGCCCCCTTGTCACACGATATGGTGAATTATATCAACAAGGTCAACACTACATGGAAGGCTGGACACAACTTTGCTAATGCTGATCTACACTATGTAAAGCGGCTCTGCGGAACTCTCCTTAAGGGCCCCCAGCTGCAAAAGAGGTTTGGGTTCGCTGATGGCCTGGAGCTTCCTGACAGTTTTGATTCCCGGGCAGCCTGGCCCAACTGTCCCACCATCCGGGAGATCCGAGATCAGGGATCCTGCGGCTCTTGCTGGGCATTTGGTGCAGTAGAAGCCATCTCTGACCGTGTTTGTGTGCACACCAATGGGAAGGTGAATGTGGAGGTGTCGGCAGAAGATCTCCTGTCCTGCTGTGGCGATGAATGTGGCATGGGTTGTAACGGAGGGTACCCGTCTGGAGCCTGGCAATTCTGGACGGAGACCGGTCTGGTATCTGGGGGCTTGTACGACTCTCATGTTGGCTGCAGGCCCTACTCGATCCCTCCCTGCGAGCACCACGTGAATGGCTCAAGGCCGGCCTGCAAGGGGGAAGAGGGCGATACCCCAAAGTGCGTGAAGCAGTGCGAGGAAGGCTACTCTCCAGCCTATGGGACCGACAAACATTTTGGAACCACGTCCTACGGTGTTCCAACCAGTGAGAAGGAAATCATGGCTGAAATCTACAAGAACGGCCCAGTAGAAGGAGCTTTCTTGGTCTATGCTGACTTTCCCCTGTACAAGTCGGGTGTTTACCAACATGAAACCGGAGAAGAACTTGGAGGTCATGCTATAAAGATCCTGGGATGGGGTGTGGAAAATGGCACCCCCTACTGGCTGTGTGCAAACTCCTGGAACACAGACTGGGGTGATAATGGCTTCTTCAAGATTCTGCGTGGAAAGGATCACTGTGGGATTGAGTCCGAGATTGTTGCCGGAGTTCCCAAAAACTAGAGCTTTTATCAATTTCTTTTAACTCTGAAGTCTGCTGCGATATGATTTTTTATTTAGAGGAGGAAAACGGGGTTGGGGGGCGAGAAAAACGATTCAAGTAAAATATCACTAGGGCTACTTTTCTATGGCAACAGGACTAAGAGCAGGGCATGCTGGGAAACTAATCCTTGTTGCCCTAGAAAGTGATGTACTGGCCCAGCAATTCTGCAACTCCCAGGAACCCACTGGGAGTTGCTGTAACATCAATATTTGGAAGCTGCCAATCCCTGTAATAGGAATAATCTACAATTTTATTTTTTTTTTCGGGGGGGGGGGGGTGGCAGGGGAATCCCCACAGACCGACGCACCTCATTTAAATAATTTTAATTGTTTCCACCGCTGTGATTGGAGGGCTCCATTGTGCGACAGTTTAATGAGTCTATAGATATTAGTTTTTTTTTTTTTTAATTCATAAGGGGGTTGTTCTACTCCTGGTTCTACCCGCAACCACTATATGATTCTGTGTAACTCCTGCCATTGCTTCTGACACTTGTGATCCTGGTGCACAACTTCAATGCCATTTAAAGCTACAGGCATCGGTGTGGGCGGAGCCAGCCCATGAAACCGAACGCTTAGGAACGAGCAATTCCTTGGATGATACCACGTGCCTCTTGTATACACGGCTCATGTTGCCTTTTTTAGTTTGTCTTTTAAAAAGATGGTAGTGTCAATTGTTTTAATTTGCCAATAAAATGCCTTCGTCTTCCTTTTAAAAAAAAAAAAAAAA
Protein		Refseq >NP_989225\|cathepsin B precursor [Xenopus (Silurana) tropicalis] MWQPVVVLCFLASIASARHLPFFAPLSGDMVNYINKMNTTWKAGHNFANADLHYVKRLCGTHLNGPQLQKRFGFADGMELPDSFDSRAAWPNCPTIREVRDQGSCGSCWAFGAVEAISDRVCVHTNGKVNVEVSAEDLLSCCGFECGMGCNGGYPSGAWKFWTETGLVSGGLYDSHLGCRPYSIPPCEHHVNGSRPACKGEEGDTPKCVKQCEDGYAPVYGSDKHFGATSYGVPSSEKEIMAEIYKNGPVEGAFLVYADFPMYKSGVYQHETGEELGGHAIKILGWGVENGTPYWLCANSWNTDWGDNGFFKILRGKDHCGIESEIVAGIPKN	Refseq >NP_001079570\|cathepsin B [Xenopus laevis] MWHLVVALCFLASIASSRHLPYFAPLSHDMVNYINKVNTTWKAGHNFANADLHYVKRLCGTLLKGPQLQKRFGFADGLELPDSFDSRAAWPNCPTIREIRDQGSCGSCWAFGAVEAISDRVCVHTNGKVNVEVSAEDLLSCCGDECGMGCNGGYPSGAWQFWTETGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPACKGEEGDTPKCVKQCEEGYSPAYGTDKHFGTTSYGVPTSEKEIMAEIYKNGPVEGAFLVYADFPLYKSGVYQHETGEELGGHAIKILGWGVENGTPYWLCANSWNTDWGDNGFFKILRGKDHCGIESEIVAGVPKN

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.64840	Xl.5191
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		2 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CTSB
mouse		MGI	Ctsb	All(4) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN ZFIN	ctsba ctsbb

Publications
First:		Purification and properties of embryonic cysteine proteinase which participates in yolk-lysis of Xenopus laevis. [Comp Biochem Physiol B Biochem Mol Biol 1998]
Most recent:		Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity. [J Biol Chem 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		cathepsin B activity cysteine-type endopeptidase activity cysteine-type peptidase activity
Biological:		proteolysis
Cellular Component:
EC:		cathepsin B
KOG:		[O] Cysteine proteinase Cathepsin L

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.4483.1.S1_at [+] Str.47638.1.A1_at Str.47638.1.A1_x_at	Xl.5191.1.S1_at
Affymetrix 2.0			Xl2.5191.1.S1_at

Symbol legend[+]