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Summary Expression Gene Literature (19) GO Terms (10) Nucleotides (402) Proteins (52) Interactants (308) Wiki
XB-GENEPAGE-1008579
Gene Symbol:
plp1

Gene Name:
proteolipid protein 1

Synonyms:
plp , pmd , hld1 , mmpl , spg2 , plp1-a , plp1-b ( Add synonyms , Nomenclature history )

Gene Function:
Neuronal membrane glycoprotein/Myelin proteolipid protein

Protein Function :
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
hereditary spastic paraplegia 2 [+]

OMIM:
PELIZAEUS-MERZBACHER DISEASE; PMD [+]

External Links:
 
Xenbase Gene ID XB-GENE-1008580 XB-GENE-1008585 XB-GENE-6255820
Gene Symbol plp1 plp1.L plp1.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 613099
398334
379423
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine plp1 plp1.L plp1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PLP1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Plp1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Plp1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR plp1a plp1b ZFIN Ensembl
chicken
GEISHA PLP1 Ensembl
fruit fly
worm
Publications
First Expression of adenylate cyclase-coupled osseous parathyroid hormone and parathyroid hormone-like peptide receptors in Xenopus oocytes., J Biol Chem 1991  
Most Recent Bruton''s Tyrosine Kinase Inhibition Promotes Myelin Repair., Brain Plast 2020          
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 2 terms 2 terms
PANTHER plp1
KEGG Pathways K17271 K17271 K17271
KOG [X] Neuronal membrane glycoprotein/Myelin proteolipid protein
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks plp1
ORFs plp1 ORF1 plp1.L ORF1 plp1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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