Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (24) GO Terms (24) Nucleotides (900) Proteins (41) Interactants (259) Wiki
XB-GENEPAGE-1009629
Gene Symbol:
sparc

Gene Name:
secreted protein, acidic, cysteine-rich (osteonectin)

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Matricellular protein Osteonectin/SPARC/BM-40

Protein Function :
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. ...[+]



Interactants:
Loading ...

Diseases: 


OMIM:
OSTEOGENESIS IMPERFECTA, TYPE XVII; OI17

External Links:
1/2
 
Xenbase Gene ID XB-GENE-1009630 XB-GENE-17342256 XB-GENE-1009638
Gene Symbol sparc sparc.L sparc.S
Chromosome Chr03 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 394973
379441
379277
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine sparc sparc.L sparc.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SPARC OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Sparc MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Sparc Ensembl
zebrafish
ZFIN, AGR sparc ZFIN Ensembl
chicken
GEISHA SPARC Ensembl
fruit fly
FLYBASE SPARC Ensembl
worm
Publications
First Expression of SPARC/osteonectin in tissues of bony and cartilaginous vertebrates., Biochem Cell Biol 1991  
Most Recent Bone regeneration after traumatic skull injury in Xenopus tropicalis., Mech Dev 2018            
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 23 terms 8 terms 7 terms
PANTHER sparc
KEGG Pathways
KOG [W] Matricellular protein Osteonectin/SPARC/BM-40
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks sparc
Antibodies Sparc Ab1 Sparc Ab1
Morpholinos sparc MO1 sparc MO1 sparc MO1
ORFs sparc ORF1 sparc.L ORF1 sparc.S ORF1 , sparc.S ORF2
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556