kcna1 Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

Gene Literature (141)

XB-GENEPAGE-1010661

[provisional- machine annotated only]

Gene Symbol: kcna1 [Predicted: Source is Human Entrez Gene]

Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) [Predicted: Source is Human Entrez Gene]

Synonyms: kv1.1, k(v)1.1 Add Xenopus synonyms

Gene Function: Voltage-gated shaker-like K+ channel KCNA

Interactants: kcna2(40) , kcna3(31) , kcna4(26) , kcna5(19) , kcnb1(16) , kcna6(14) , kcnj2(13) View All

XB-GENE-1010662

XB-GENE-1010663

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	NCBI Nucleotide >CR761736\|Xenopus tropicalis finished cDNA, clone TGas050c02 CCCGGGGCGGGAAAGGAGGGGTCGGAGGAGCAAGGGATGGCAGAAGGAGACCTATATATCTCTGTGTGCGCTCCATCAGCTAGATTCCATAGTCTGGGAGGTAAAAAGGAGGAATCTCCGCAAATGCTTTTAATATACAAGACGCAACAAGATTCTACCAGAGAGAGCTGGGAGGGGAGCCTGCGGCTCATGTAGTGGGCTGAAGGAGGAGGCCACCGCGCTTCTCCTACCCGCCCAACCCCTCATCTCACCTTTATGGACGAGCACCTCAGTCTCCTGCATTCGCCTCCTCCATCCTCCACCAGACACAGAACCAACTCGAACATAGTTAACCCAGGCTACACGGACTTGGAGCAGGAGATCATGACTGTGGTGGCGTGTGATAACATCCTGGAGGAGGCGGCTGCCCTGCCGGGGCACCACTCTAGCGAAGCCTACGAGCAAGAGGACCATGAGTGCTGTGAGAGGGTAGTGATCAATATATCCGGCCTTCGCTTTGAGACCCAGCTGAAGACTTTAGCCCAGTTTCCCGACACCTTGCTCGGCGACCCCAAGAAAAGGATGCGATACTTCGATCCCCTGCGGAACGAATACTTTTTTGACAGGAACCGCCCCAGTTTCGATGCCATCCTTTACTACTACCAGTCGGGCGGCAGGATCAGGAGACCGGTGAACGTTCCCATAGACATTTTCTCAGAAGAGATCCGCTTCTACGAGCTGGGGGAAGAAGCCATGGAGAAGTTCAGAGAAGATGAGGGCTTTATCAGGGAAGAGGAGCGGCC	Refseq >NM_001085777\|Xenopus laevis potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (kcna1), mRNA AAATGACCGTAATCGCAGGGGAGAATATGGACGAGACCTCAGTATTGCCCGGTCACCCTCAGGACAGCTACCATCCAGACCAAGATGACCACGAATGCTGTGAGAGGGTGGTCATCAATGTGTCCGGCCTACGCTTCGAGACCCAGCTTAAGACTCTCGCTCAGTTCCCCAGCACTCTGCTAGGGAACCCCAAAAAACGGATGCGTTACTTTGACCCCCTGAGGAACGAGTACTTCTTTGACCGAAACCGTCCAAGTTTCGATGCCATATTATATTACTACCAGTCTGGGGGTCGACTCCGGAGACCTGTTAATGTTCCACTGGACATGTTCTCTGAGGAAATCAAGTTTTATGAGTTAGGGGAAGAGGCCATGGAGAAGTTTAGGGAGGATGAGGGTTTCGTAAAGGAAGAGGAACGCCCTCTGCCAGATAAAGAGTTCCAACGCCAGGTGTGGCTCTTGTTTGAGTTCCCCGAAAGCTCCGGCCCGGCCAGGATCATTGCCATAATATCTGTGATGGTCATCCTTATATCAATTGTTATCTTCTGCTTGGAGACTTTGCCAGAATTAAAAGATGAGCGGATCTTCAGTCGACGGGTGAACAACAGCACAGTTTTCTACAAATCCAACATCTTCACGGATCCATTCTTTGTGGTGGAGACCCTCTGCATTATCTGGTTTTCCTTTGAATTGGTGGTGAGGTTCTTTGCATGTCCCAGCAAACCGGAATTCTTTAAGAACATCATGAACTTCATTGACATTGTGGCCATCATCCCTTACTTTATCACCTTGGGGACTGAAATGGCAGAGCAAGAAGGTCCCCAAAAAGGAGAACAGGCAACATCTTTGGCAATCCTGAGGGTCATCAGACTGGTAAGAGTGTTTAGAATCTTCAAACTCTCCAGGCATTCTAAGGGACTCCAGATTTTGGGACAGACCTTGAAAGCTAGCATGAGAGAATTAGGGTTGCTAATTTTTTTTCTATTCATTGGGGTCATCTTGTTCTCCAGTGCAGTGTACTTTGCTGAAGCTGAAGAGGATGAATCTCATTTTACAAGTATCCCTGATGCTTTCTGGTGGGCGGTGGTATCCATGACCACTGTGGGCTATGGTGACATGTACCCTGTGACAATTGGAGGCAAAATCGTGGGCTCCTTGTGTGCCATCGCTGGTGTGCTGACAATTGCCCTGCCTGTACCTGTCATCGTGTCCAACTTCAACTACTTCTACCACCGAGAAACTGAAGGGGAGGAACAGGCTCAGTTACTCCATGTTAGCTCCCCCAATTTAGCCTCTAACAGTGATCTGAGTCGACGAAGTTCCTCCGCAATGAGCAAATCTGAGTACATGGAGATTGAAGAGGATCTGAATAATAGCATAGATAACTTTAGAGAGGCAAATATCAGAACTGGCAATTGCACCATAGCCAATCAGAACTGTGTTAACAAAAGCAAGCTCCTGACAGATGTGTAGACACGACAGTCCCATTACAGAATTATCATGACCACTTCCCTCTTTGCAGGGCCACCATGAACTTAACCTTCAAAAATACAGAGGCCTAGTACAAATTAGGGGAGC
Protein	NCBI Protein >CAL49368\|potassium voltage-gated channel, shaker-related subfamily, member 2 [Xenopus tropicalis] MTVVACDNILEEAAALPGHHSSEAYEQEDHECCERVVINISGLRFETQLKTLAQFPDTLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYELGEEAMEKFREDEGFIREEERP	Refseq >NP_001079246\|potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) [Xenopus laevis] MTVIAGENMDETSVLPGHPQDSYHPDQDDHECCERVVINVSGLRFETQLKTLAQFPSTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFVKEEERPLPDKEFQRQVWLLFEFPESSGPARIIAIISVMVILISIVIFCLETLPELKDERIFSRRVNNSTVFYKSNIFTDPFFVVETLCIIWFSFELVVRFFACPSKPEFFKNIMNFIDIVAIIPYFITLGTEMAEQEGPQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEDESHFTSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASNSDLSRRSSSAMSKSEYMEIEEDLNNSIDNFREANIRTGNCTIANQNCVNKSKLLTDV

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.26868	Xl.825
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	1 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	KCNA1	OMIM:160120
mouse	MGI	Kcna1	All(4) Targeted, knock Out(2) Targeted, other(1) Spontaneous(1)
zebrafish

Publications
First:		The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. [Cell Mol Neurobiol 1991]
Most recent:		A competition-based mechanism mediates developmental refinement of tectal neuron receptive fields. [J Neurosci 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		cation channel activity ion channel activity potassium channel activity More[+] protein binding voltage-gated potassium channel activity
Biological:		cation transport ion transport potassium ion transport
Cellular Component:		membrane voltage-gated potassium channel complex
EC:
KOG:		[P] Voltage-gated shaker-like K+ channel KCNA

Reagents	tropicalis	laevis
Clones	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.26868.1.A1_at [+] Str.26868.1.S1_at StrEns.852.1.S1_at	Xl.825.1.S1_at
Affymetrix 2.0		Xl2.825.1.S1_at

Symbol legend[+]