[provisional- machine annotated only] Gene Symbol: nrg1 [Predicted: Source is Human Entrez Gene] Gene Name: neuregulin 1 [Predicted: Source is Human Entrez Gene] Synonyms: heregulin, heregulin-alpha Add Xenopus synonyms Gene Function: beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain Interactants: egf(2) , egfr(2) , erbb4(1) , nkx2-5(1) , View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002933991|PREDICTED: Xenopus (Silurana) tropicalis pro-neuregulin-1, membrane-bound isoform-like (LOC100496613), mRNA CAGAACTATACAACTTGGAGGAACTAAGAAGAGTTTTTTGTTTTTTTTTTACAGAAAAGGCAATTTTTACAGATACAAGGGCACAATAGAAACTTTTTTTTAAACTTTTATCTTTTGATACATATATGTCTTATTTTGTAGTATTATCCTGATTTCAGAGAAAAAGGAATATACCTGCCTCCTAACTTTCAGACTGGGATTTGGTTTTGGATTATGTGCTCCTTGCCTGTGCCCTGCTCTCTTGCTCTGATCTAATTAGCTGTGTCCTAGTGATCTGGCCGATTGAGTGCAGAGGGGGAGGCTAATGAGAGAGTGCGACCAGGCGCTGTCACACCAGGGATAACGAGTTTGGGGTCAGTCCCCAGTGCCTAGGGTCAGGCAGCCGGTCGGCTCACACAGCTGCATAAGGAACTACCACGTTTCAGTGGGGAGAACTAAAGGCACAAAAGGAAAACTGGATTTTATTTTGCAAAGGTTTCACTCGAGAAGTTTAAAGTCCGTCACCATGGCTGAGAAGAAGAAGGAAAAAGAAGGAAAGGGAAAAAAAGGGAAAGGGAAAAAGGACAGGAAAGGGAAGAAAGCAGAGGGCAATGCCCAAGGCGCAGCTGCACCTCCAAAATTAAAAGAAATGAAGACTCAAAGTGTACAAGAGGGAAAGAAGCTTGTGCTGAAATGTCAAGCAGTTTCTGAACAGCCATCTCTAAAATTTAGATGGTTTAAAGGAGAAAAAGAAATCGGAGCAAAAAATAAGCCAGATAGCAAGCCTGAACACATTAAGATAAGGGGAAAAAAAAAATCTTCAGAACTTCAAATTAGCAAAGCTTCCAGTGCAGATAATGGTGAATACAAATGTACAGTGTCAAACCAGCTTGGAAATGACACCATGACCGTCAATGTCACCATAGTACCAAAACCCACTTTACAGCCATTTACACCTGATCAAATTTTACCAAAAGTTACATCAGTAGGAAAATCAGTTGAGCCTTCTACCCTAAATCTAATTGGAACCACAGAAAGAGGTCGTTTAGCTACTACTAAAAGGGGTGACACCACAACTGGACCAGGTCACCTTATAAAATGCTCAGACAAAGAAAAGACCTACTGTGTCAACGGAGGAGAGTGCTATGTCCTCAATGGTATAACAAGCAGCAACCAGTTCATGTGCAAGTGCAAACCTGGATTCACTGGAGCAAGATGCACTGAAACTGATCCATTGAGAGTCGTAAGATCAGAAAAGCATCTTGGAATTGAATTTATGGAAGCTGAGGAGTTGTACCAGAAAAGAGTGTTGACCATTACCGGCATCTGCATTGCACTTCTTGTAGTTGGCATCATGTGTGTTGTGGCCTACTGCAAAACCAAGAAACAGAGAAAAAAGTTGCACGACCGTTTAAGACAAAGCCTCCGATCAGAAAGGAACAACATGGTGAACATGGCGAATGGACCTCACCATCCAAACCCACCTCCAGAAAATGTCCAGCTGGTAAATCAGTATGTTTCGAAAAATGTCATATCCAGTGAACATGTTATTGAGCGGGAAACAGAAACATCTTTCTCTACAAGTCATTATACTTCAACAACACATCATTCAACAACTGTTACTCAAACACCAAGTCACAGCTGGAGTAATGGTCAATCAGAAAGCATGATTTCAGAGAGCCACTCGGTAATTGTTACATCATCGGTGGAAAACAGCAGGCACACAAGCCCAACGGGGCCCAGGGGGCGTCTGAATGGTATTGGAGGGCCTAGAGACTGTAGTTATCTCAGGCATGCCAGAGATACTCCAGATTCATACAGAGATTCGCCACACAGTGAAAGATATGTTTCAGCCATGACTACACCAGCCCGCATGTCACCAGTAGAATTTCAGACACCGATCTCTCCTAAATCACCTTGTTTGGAAAGGTCTCCACCTGAATCTAGCTTAGCTGTATCTGTTCCATCAGTGGCTGTAAGCCCCTTTATAGAAGAAGAAAGACCTCTACTTTTGGTGTCTCCACCAAGGTTACGAGACAAAAGATATGACTTATATTACCACCATCACCACTACAACCAGCAGTACAATTCCTACCATCACAATCCTGCCCATGACAGCAGCAGCTTACCGCCAAGTCCTTTAAGAATAGTAGAAGATGAGGAGTATGAAACCACACAGGAGTATGAGCCGTCACAAGAGCCTGCAAAGAAATTAGTCAACAGCCGAAGGGCAAAAAGAACAAAACCCAATGGCCACATTTCCAATAGATTAGAACTGGACACTGACACAAGCTCCGAGAGCAGTACATCAGAGAGTGAGACAGAAGATGAAAGAATAGGCGAGGAAACACCTTTCCTGAGTATACAGAACCCACTGGCAGCCAGCTTAGAGTCAGCAAGTTTATACCGACATGCTGACAGCAGGACTAACCCAACTAGCCGATTCTCAACGCAGGAAGAGTTACAAGCAAGGCTGTCCAGTGTAATAGCGAATCAAACCCTATTGCTGTATAAAACAAGACAAAGAATGACCTGTAAAACTTTATTTTATATAATGAAGTATTCCACCTTAACTTAAACAATTTATTTTATTTTAACAGTTCCGCAACTAGAACAGGAAAAATTTTATAAATTAAGTATATGTACAAATGTGTTATGTGCCATATGTAGCAATTTTTTACAGTATTTCAAACTAAGAGACATCAATGGTGCCTTTATGTTATGTTATGTTGATAACAATTTTGTAC	Refseq >NM_001085594|Xenopus laevis neuregulin 1 (nrg1), mRNA GGCACGAGGTGATGTTCACTGTGCAGGCACCTGCTGCTCTGTAATGATTCAGCCTCTTTCACTCGCAGCCTCAACACAACAGGATGGTATTGCTGCTGTCACTGCTGCCTCGTTTACTGCTGTTTCCGTTGTTACTTGCTTTTTTATTGTTGCTGCTTCATGACAGTTATTTTCTACCAAACAGATACCATCTTCAGATGCTGCAGGTGAGAGAACAGCAATTTACTCTTGGCTATTGGTTTACCTGGCTAAATGACAGCTAGCTGTATCTGCAACCTCATAGAAAACATGTTGAAAGGGAGAGTTCTAATACAAAACTAAGAGATATCTGATATATAGCTGCTATATTCTTTTTGTAAAGAATATAATTTAGTTACACTTTTCAACAACCTGCTGAGACGACTTTCTGATTTACTGGATAAAATGCAGATATCGTTTTTAGAACATGTAGCCCTGCTTTTTCTGGTAATGGAACACATAAAGATCCAAGCTTCAATAAAGCAAGCTGCTTGAAATTTATGCCTTTAAGATGTCTGAAGATACTGCAGAGGGTTTGCAGAACCAGTGCTCTGAGCAGAGCTCAGACCCCCCCTCTGCTGAACTTCAGAATGAAGAAAGCATGCCAGAGACTCAAGATGAGGAGGAAACGACCCATGGGATTACAGGCCTTGCTATTACCTGCTGTGTATGTCTTGAGGCAGACAGGCTGAGAATCTGCCTTAACTCTGAGAAGATTTGCATAATCCCTATCTTGGCATGTCTGATTAGTCTGTGTCTCTGCATCGCGGGCCTTAAATGGGTGTTTGTAGATAAAATATTTGAGTATGACTCTCCTACACATTTGGACCCTGGCCATAGAGGCCAAGATCTTATCCTTTATACTGACACAGCTCCATCTACTTTGGTGCCATCCTCTGTTCGTACTTTACCTGTCATTATTCCTACAACTGATTCTAAGGCTGCAGTTACATTCAAATTTGGAACTTCTCTTTTACCCACAGAACCCACTTACAACCATTTACTTCTGATGAAAATTTACTTAAAAGTTACATCAGTAGAAAAATCAGTTGAGCCTTCTACCCTAAACCTATTGGAATCACAGAAAGAGGTTATTTTTGCTACAACCAAAAGGGGTGACACCACAGCTGGGCCAGGTCACCTTATTAAGTGTTCAGACAAAGAGAAGACCTACTGTGTCAATGGAGGAGAGTGTTATGTACTCAACGGTATAACAAGCAGCAACCAGTTCATGTGCAAGTGCCCAAATGAATTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAAGCTGAGGAGTTGTACCAAAAAAGAGTGTTGACCATAACCGGCATCTGCATTGACCTTCTTGTAGTTGGCGATATGTGTGTTGTGGACGCCTACTGCAAAACCAAGAAACAGAGAAAAAAGTTGAATGACCGTTTAAGACAAAGCCTCAGAGAGAGAAACAAAAACATAACAAACAAGGACAACAGACCTCACAACCCAAAGAACCCACCTCCCAGAAAAAATGTCCAGCTGGTAAATCAGTATGTCTCAAAAAATGTCATATCAAGCGAACACGTGATTGAACGGGAAACAGAAACATCTTTCTCTACAAGCCATTATACCTCGACAACACATCACTCAACAACTGTTACACAAACACCAAGTCACAGCTGGAGTAATGGTCTATCAGAAAGCATGATTTCAGAAAAAAGTTACTCAGTAATAGTTACATCATCGGTGGAAAACAGCAGGCACACAAGCCCAACAGGGCCAAGGGGGCGTCTTAATGGTATTGGAGGACCTAGAGACTGTAGTTATCTCAGGCATGCTAGAGATACTCCAGACTCTTACAGAGATTCACCACACAGTGAGAGATATGTTTCAGCTATGACTACACCAGCCCGCATGTCACCAGTAGAATTCAAGACACCAATCTCTCCTAAATCGCCTTGTTTGGAAACGTCTCCACCTGAATCTAGCTTAGCCGTTTCTGTTCCATCAGTGGCTGTGAGCCCCTTTATAGAAGAAGAAAGACCTCTTCTTTTGGTGTCTCCACCAAGGTTACGAGAAAAGAGATATGACAGAAAAACACCACAAAAAACACCACACAAGCAGCACAATTCCTACCATCACAATCCTGGCCATGACAGCAGCAGCTTACCGCCGAATCCTTTAAGAATAGTAGAAGATGAGGAGTATGAAACCACACAGGAGTATGAACCGTCACTAGAGCCTGCAAAGAAATTAGTCAACAGCCGAAGGCAAAAAAGAACAAAACCCAATGGCCACATTTCCAATAGATTAGAACTGGACAGTGACTCAAGCTCCGAGAGCAGTACATCTGAGAGTGAGACAGAAGATGAAAGAATAGGCGAGGAAACACCTTTTCTGAGTATACAGAACCCACTGGCAGCCAGCTTAGAGTCCGCCAGTTTATACCGACATGCTGACAGCAGGACTAACCCAACTAGCCGATTCTCAACACAGGAAGAATTACAAGCAAGGTTGTCCAGCATAGCGAATCAAGCCCTATGCGATCAAAAGAAGCGAAAAATGACCTGTAAAACTTTATTTATATAATGAAGTATTCCACCTTAACTTAAACAATTTATTTTATTTTAACAGTTCCGCAATTAGAACAGGAAAATTTTATAAATTAAGTATATGTACAAATGTGTTATGTGCCATATGTAGCAATTTTTTACAGTATTTCAAACAAAGAGATATCAATGGTGCCGCTTTATGTTATGTTATGTTGATAACAATTTTGTACGTCCCATTGATTGCTGTCCCACTGTGTTTTTGCTGAACTTTATGACTTTATTTTTCTTGGGCTTTTTGTGCATTGCATCTATGGTGTGGACTGAATGTGTAGTTTTCAAGAGTTGCAACTATTCCCTATATTTGCTTGTTGTACTGTAGCTTCCTGATTAGCTATCCCTGGAATGCAGTGCAATACTGTGTTCTCCTACGATGGGTAGTGATTTGCTTTCAGTACAGTATATAAAACATAATATCTGAGCTGCCAGCCAAAGTTTTGCTTTATGGGTAAATGAGTAGGTTGAAGAGCATGCTTCTGTTAACTACATCAGGATAGTGCAAATAACTAACATAGAATACATAATGAATATACGCCTGCTACTGTGAAAACTGGCTAACAAAAAAAACTATAATTGTAGTGCTGTCAAATTTTCTAGTTAGCCTTGAAAACAGGTTCATGTACACTGAAGGCATCAAACCCCCCTCCCCTAAAAGAAAGCTTTCCAAACACAAATTACATTTCAGAACTCTGAATACAAAAAATTAACCTGATAAAGTAGAGGAGTCATAATAGGAGACAGATACATGATTGGTGCAATCACTTTGAACACTGATCCTCTTTATTTTTTTTAATACTTTGTTCCATATCAAACAGGGTGTATGTAAGAGATATAAACATTACAGAAATGTAGCAACTGTCCACTTATTAAAGGATTCCGCCGTATGACGGC
Protein		NCBI Protein >XP_002934037|PREDICTED: LOW QUALITY PROTEIN: pro-neuregulin-1, membrane-bound isoform-like [Xenopus (Silurana) tropicalis] MAEKKKEKEGKGKKGKGKKDRKGKKAEGNAQGAAAPPKLKEMKTQSVQEGKKLVLKCQAVSEQPSLKFRWFKGEKEIGAKNKPDSKPEHIKIRGKKKSSELQISKASSADNGEYKCTVSNQLGNDTMTVNVTIVPKPTLQPFTPDQILPKVTSVGKSVEPSTLNLIGTTERGRLATTKRGDTTTGPGHLIKCSDKEKTYCVNGGECYVLNGITSSNQFMCKCKPGFTGARCTETDPLRVVRSEKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMVNMANGPHHPNPPPENVQLVNQYVSKNVISSEHVIERETETSFSTSHYTSTTHHSTTVTQTPSHSWSNGQSESMISESHSVIVTSSVENSRHTSPTGPRGRLNGIGGPRDCSYLRHARDTPDSYRDSPHSERYVSAMTTPARMSPVEFQTPISPKSPCLERSPPESSLAVSVPSVAVSPFIEEERPLLLVSPPRLRDKRYDLYYHHHHYNQQYNSYHHNPAHDSSSLPPSPLRIVEDEEYETTQEYEPSQEPAKKLVNSRRAKRTKPNGHISNRLELDTDTSSESSTSESETEDERIGEETPFLSIQNPLAASLESASLYRHADSRTNPTSRFSTQEELQARLSSVIANQTLLLYKTRQRMTCKTLFYIMKYSTLT	Refseq >NP_001079063|pro-neuregulin-1, membrane-bound isoform [Xenopus laevis] MSEDTAEGLQNQCSEQSSDPPSAELQNEESMPETQDEEETTHGITGLAITCCVCLEADRLRICLNSEKICIIPILACLISLCLCIAGLKWVFVDKIFEYDSPTHLDPGHRGQDLILYTDTAPSTLVPSSVRTLPVIIPTTDSKAAVTFKFGTSLLPTEPTYNHLLLMKIYLKVTSVEKSVEPSTLNLLESQKEVIFATTKRGDTTAGPGHLIKCSDKEKTYCVNGGECYVLNGITSSNQFMCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIDLLVVGDMCVVDAYCKTKKQRKKLNDRLRQSLRERNKNITNKDNRPHNPKNPPPRKNVQLVNQYVSKNVISSEHVIERETETSFSTSHYTSTTHHSTTVTQTPSHSWSNGLSESMISEKSYSVIVTSSVENSRHTSPTGPRGRLNGIGGPRDCSYLRHARDTPDSYRDSPHSERYVSAMTTPARMSPVEFKTPISPKSPCLETSPPESSLAVSVPSVAVSPFIEEERPLLLVSPPRLREKRYDRKTPQKTPHKQHNSYHHNPGHDSSSLPPNPLRIVEDEEYETTQEYEPSLEPAKKLVNSRRQKRTKPNGHISNRLELDSDSSSESSTSESETEDERIGEETPFLSIQNPLAASLESASLYRHADSRTNPTSRFSTQEELQARLSSIANQALCDQKKRKMTCKTLFI UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.41024	Xl.289
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NRG1	OMIM:603013
mouse		MGI	Nrg1	All(12) Targeted, knock Out(7) Targeted, other(3) Chemically Induced(1)
zebrafish		ZFIN	nrg1	4 Lines(s)

Publications
First:		Expression of ErbB receptors in ES cell-derived cardiomyocytes. [Biochem Biophys Res Commun 2003]
Most recent:		Promotion of spermatogonial proliferation by neuregulin 1 in newt (Cynops pyrrhogaster) testis. [Mech Dev 2008]
		View All Papers

Functional Ontologies
GO: Molecular:		receptor binding
Biological:		embryonic development
Cellular Component:
EC:
KOG:		[GO] beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.41024.2.S1_a_at [+] StrEns.2419.1.S1_s_at	Xl.289.1.S1_a_at
Affymetrix 2.0			Xl2.289.1.S1_a_at

Symbol legend[+]

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