grin2d Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-1011862

[provisional- machine annotated only]

Gene Symbol: grin2d [Predicted: Source is Human Entrez Gene]

Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2D [Predicted: Source is Human Entrez Gene]

Synonyms: nr2d, eb11, nmdar2d Add Xenopus synonyms

Gene Function: Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits

Interactants: grin2a(42) , grin2c(38) , grin2b(37) , grin1(33) , nodal1(28) , nodal2(22) , gria1(2) View All

XB-GENE-1011863

XB-GENE-1021543

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	NCBI Nucleotide >XM_002934986\|PREDICTED: Xenopus (Silurana) tropicalis glutamate [NMDA] receptor subunit epsilon-4-like (LOC100496465), mRNA ATGTGTTTGCTACTTGCTGCGCATATTGCCTTTGTGCCGGCCGCTAGGATGCTATTTTTCATGGCCCTGGCTTGTGCCAGTCCGTTCCTGGAGTTTCGGGAGGAGAGCCCAAGATCCCTCAACGTAGCCATCATTTTTAGCGGAACGTCTTACCCACCCGAGAGTGCCCGCTTTGCACCTACGACCTTCCGGAACTTCTCCATGGAAGTGAATCCAATATCAGTGATTTTAAATGACACAAACCCTCGCAGCCTTATCCTGCAAATCTGTGATGTCCTCTCCAGCCTCCGCATCCACGGGGTCGTCTTTGAAGATGATACTCGAACTGAATCTGTTGCCCAGATACTTGATTTCATCTCTGCACAAACATCTATGCCCATCATTGGCATAAACGGGGGATCTGCAATTGTACTAACACCCAAGGAAAAAGGTTCTACCTTTTTGCAGTTGGGTGCGTCTACTGAGCAGCAACTACAAGTCATCTTTGAAGTCTTGGAGGAATATGACTGGACATCTTTTGCAGTAATCACCACTTTGTTTCCTGGTTATGAGGACTTTGTGGATTACATAGAGTTGCTGACGGACAGCAGCTTCATTGGTTGGGAAAACCGAGGTGTCTTGACCCTTAATTTGACTGATGACCCCAGTGGTTCCAAATTAAAAAGACAACTAAGAGAGATTACAGCTCAAGTGAGACTTCTTTATTGTTCTCGGGAAGAAGCTGATGGAGTCTTTAAGGCTGCGCGTGAGGCTGGGTTAACTGGACCAGGCTACATATGGTTCATGGTGGGAACCAATTTAGGTGGCACAGATTATATGCCCGAGCACCTTCCTGTTGGACTTTTTACAGTGCTATCTGCTGGATGGAAAGATGACCTTCACCGCAGAGTACAGAATGGAGTGGCAATAATTGCTAAAGGTGCAGAGGCTTTGTACAAGGATTTTGGATTTATACCTGAATTCAACAATGATTGCAGGGCCCCAAACCTCACTCACATGAATGAGAATCTACACAGGTATTTTATGAACATCTCGTGGGGTGGAAAGGACTTCTCTTTTAATGAAGATGGCTACCTCATTAATCCAGCTCTTGTGGTGATTGCCCTCAACAAAGAGAGGAGCTGGGAAGTGGTTGGAATCTGGGAGCATGGAGATCTACGCATGAAATACCCCGTGTGGTCCCGTTATGGGAAGTTCCTGCAACCAGTGGACGATGACCAGCATCTCACTGTCGCTACCCTAGAGGAACGTCCCTTTGTTATCGTCGAAGGCGTGGACCCAGCAACAGGCACCTGCATCCGGGATTCTGTACCCTGTCGCAAACAACTTAACAGAACTGACAACCACTTGACAGATCCCATCATTTTCGTCAAACAGTGCTGTAAGGGTTTCTGCATTGATATACTGAAACGGCTTTCTAAGACCATTGGATTTACTTACGATCTCTATCTAGTGACCAATGGAAAGCATGGAAAAAAGATTGACGGTGTGTGGAATGGCATGATTGGGGAGGTGTTTTACCAGCGGGCCGACATGGCCATCGGATCACTCACTATAAATGAGGAGCGCTCGGAGATCATTGACTTTTCAGTCCCCTTCGTGGAGACGGGGATCAGTGTCATGGTGTCCAGGAGCAACGGCACGGTATCCCCATCTGCATTTTTAGAGCCATATAGCCCTGCCGTCTGGGTCATGATGTTTGTCATGTGCCTTACCGTGGTTGCTGTGACTGTTTTCATCTTTGAGTATTTTAGCCCTGTCGGATATAACCGAAGTCTGTCCACAGGCAAACGTCCTGGAGGTTCCAAGTTTACTATCGGCAAATCAATTTGGCTTCTTTGGGCATTGGTATTTAATAATTCAGTTCCGGTGGAAAATCCTAAAGGCACCACAAGCAAAATCATGGTTCTCATCTGGGCATTCTTTGCTGTCATATTCTTGGCCAGCTACACTGCCAACCTGGCTGCCTTTATGATCCAGGAAGAATATGTAGATACCGTGTCTGGACTCAGTGATAAAAAATTCCAGAGACCTCATGAACAGTACCCGCCTCTGAAATTTGGCACTGTTCCCAATGGCAGTACTGAAAAGAACATTCGTAGCAATTACCCAGATATGCATGCCTACATGATCAAATACAACCAGCGGCACGTGGAGGACGCCTTGCAAAATCTTAAGACTGGGAAACTGGACGCGTTCATCTATGATGCAGCTGTTCTAAACTACATGGCACGAAAGGACGAGGGTTGTAAACTGGTCACCATTGGCAGCGGGAAAGTCTTTGCCACCACAGGATATGGAATCGCTTTACAGAAAGGTTCAAAATGGAAACGGCCCATCGACCTTGCATTGCTTCAGTTTCTAGGTGACGATGAGATTGAAATGCTGGAGAGACTGTGGTTATCAGGAATTTGCCATAATGACAAAATTGAGGTGATGAGCAGCAAATTAGACATCGACAACATGGCTGGTGTATTCTATATGCTTCTGGTTGCTATGGGATTAAGCCTTCTTGTTTTTGCTTGGGAGCATCTCATATACTGGAAGCTTCGACACTGCATGAGGCATTCTGGGAAATTGGATTTCCTGTTGGCATTCAGCAGGGGCATGTACAGTTGTTGTAGTGCTGAAGATCCAAAGGATTCAGATCAACAGCTTCCAACACTGAACCATTGTTATCCATCCCAGAGGTTACCAGCCCTGCCCAACTCATCTGTTCCGCCACCACCACTGCCTTCAGCACCATTGCCATGTTCTAACTTCATACCAAGAGAAAGACGTGTTGTAGAGAGGTGGCGCCATGCAAGAAGTCCAAATTGTTACAAAGATATTTACACACCTACCCGTTCTGTACATGACCCAAACAATAAAGCGGCTCCTCCTAGACTTCCTCATAAAAATGCATTCTCTGATGGATTTCACCGCTATTATGGGCCAATCGAACCTGAAGGACTATCAGACCATTTGGTCGAGTCAGGGCAAGCATTTGGCAAAGATAAAAAGATGGCATCATGCCAAATGTCACCACAAACTCAAAGGGAACATTTCTTAGAAAACCCACCCTCCTATTTTGCAATTGTACGGGAAAAAGATGCCCCAGAGCCACCAGGGTGGCAGTCAAAAATTTCCAGAGGCCTTTATGAGAACTACCAGTCAGGAAAGGAGAGAACACCAAAGTCTACAGCTGGAGCACGAGGTAGTCGAACACCGGAAACTGCAGCAAAGAAATTCGATCACTTGGGAAGCAGCTACCAATCAAAGGGCACATGTGAAATAGAACGAGAGGTTTATAATAGTGGAGGACCCAGTAGCAGTAGCAATCGCCCCAACAAAGCCAGTGTGGATTTATTTGATCAACCCCACTATAGCGGCCATACAAGATTCACATATGAAGATGAGAGAAGTTGTGGGAGGGACTGCCATCATCGCAGAGATGACATGGACTTAGAATCCCAGCCTTTACTGCATAAAAAATCCAGCCGCTCACACATGTGCAGAAGTCACTCTCATCCCTTAGTTATGGGTGCCAGTAAAAGCAAATATGCTGACCTTTCAGATTCCGATTCAGATGTATGTGAGCGAGACCCTCCTTGTGTAAAAACAGAAATGGGCCATAACTGTTGGTATTCACCAAATTACTTCTGCACATATCCATCCAGGGAACGACAAGCATCATCTGCCCCACACAAGCCAATGAGGTACTGGTCTGTAGATAAGTTAGGCAAGTATCATCAGTTAAGCAAAGAGTATCTTCCGGGCACATGTCATGGCTCTTGTTATTGCAGTAGTTTAGAAATGCTGCAACCTCACTGCCACAAAGAGCCGAGATACTTTAGCTGCTCAGACGAGAAGCTTGAACGACGGTTAGACTGGGAGCACTTTCGTAGTGGTCACTGCTCCTTCCTTCACCATCATCACCACTCCTGTGACTTAGCTCCTATTCATCCCACATCACGGAGTTTAGAGGACCTCAGCAGATGCCACTTGAGGTGCCACAGACACATCTTCTCACCAGAATGCCAACCTAGATCAAGCCACAGCGGAACCCTTTATAAAAGAAGGGGTTCTGCACACTTCTCTAGTTTGGAATCAGAAGTATGA	NCBI Nucleotide >EU104356\|Xenopus laevis ionotropic glutamate receptor subunit NR2D (NR2D) mRNA, partial cds CAACAAAGAGAGGAGCTGGGAAGTGGTTGGAATCTGGGAGCATGGGGAGCTACGGATGAAATACCCCGTGTGGTCCCGTTACGGGAAGTTCCTGCAACCTGTGGATGATGACCAGCATCTTACTGTCGCTACCCTAGAGGAACGTCCCTTTGTTATTGTTGAAGGTGTGGACCCAGCAACAGGCACCTGCATCCGGGATTCTGTACCCTGCCGCAAACAACTTAACAGAACTGACAACCAATTGACAGACCCTATCATATTCGTCAAACAATGCTGTAAGGGTTTCTGCATTGATATACTGAAA
Protein	NCBI Protein >XP_002935032\|PREDICTED: glutamate [NMDA] receptor subunit epsilon-4-like [Xenopus (Silurana) tropicalis] MCLLLAAHIAFVPAARMLFFMALACASPFLEFREESPRSLNVAIIFSGTSYPPESARFAPTTFRNFSMEVNPISVILNDTNPRSLILQICDVLSSLRIHGVVFEDDTRTESVAQILDFISAQTSMPIIGINGGSAIVLTPKEKGSTFLQLGASTEQQLQVIFEVLEEYDWTSFAVITTLFPGYEDFVDYIELLTDSSFIGWENRGVLTLNLTDDPSGSKLKRQLREITAQVRLLYCSREEADGVFKAAREAGLTGPGYIWFMVGTNLGGTDYMPEHLPVGLFTVLSAGWKDDLHRRVQNGVAIIAKGAEALYKDFGFIPEFNNDCRAPNLTHMNENLHRYFMNISWGGKDFSFNEDGYLINPALVVIALNKERSWEVVGIWEHGDLRMKYPVWSRYGKFLQPVDDDQHLTVATLEERPFVIVEGVDPATGTCIRDSVPCRKQLNRTDNHLTDPIIFVKQCCKGFCIDILKRLSKTIGFTYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYFSPVGYNRSLSTGKRPGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLIWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDKKFQRPHEQYPPLKFGTVPNGSTEKNIRSNYPDMHAYMIKYNQRHVEDALQNLKTGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALQKGSKWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLIYWKLRHCMRHSGKLDFLLAFSRGMYSCCSAEDPKDSDQQLPTLNHCYPSQRLPALPNSSVPPPPLPSAPLPCSNFIPRERRVVERWRHARSPNCYKDIYTPTRSVHDPNNKAAPPRLPHKNAFSDGFHRYYGPIEPEGLSDHLVESGQAFGKDKKMASCQMSPQTQREHFLENPPSYFAIVREKDAPEPPGWQSKISRGLYENYQSGKERTPKSTAGARGSRTPETAAKKFDHLGSSYQSKGTCEIEREVYNSGGPSSSSNRPNKASVDLFDQPHYSGHTRFTYEDERSCGRDCHHRRDDMDLESQPLLHKKSSRSHMCRSHSHPLVMGASKSKYADLSDSDSDVCERDPPCVKTEMGHNCWYSPNYFCTYPSRERQASSAPHKPMRYWSVDKLGKYHQLSKEYLPGTCHGSCYCSSLEMLQPHCHKEPRYFSCSDEKLERRLDWEHFRSGHCSFLHHHHHSCDLAPIHPTSRSLEDLSRCHLRCHRHIFSPECQPRSSHSGTLYKRRGSAHFSSLESEV	NCBI Protein >ABU84988\|ionotropic glutamate receptor subunit NR2D [Xenopus laevis] NKERSWEVVGIWEHGELRMKYPVWSRYGKFLQPVDDDQHLTVATLEERPFVIVEGVDPATGTCIRDSVPCRKQLNRTDNQLTDPIIFVKQCCKGFCIDILK

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene		Xl.83883
Unigene EST Profile		EST Profile
GEO data		GEO
Images	0 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	GRIN2D
mouse	MGI	Grin2d	All(2) Targeted, knock Out(1) Targeted, other(1)
zebrafish

Publications
First:		Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor. [J Biol Chem 1993]
Most recent:		Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and neuroprotective effects in in vitro and in vivo. [Neurosci Lett 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		extracellular-glutamate-gated ion channel activity growth factor activity ion channel activity More[+] ionotropic glutamate receptor activity receptor activity transporter activity
Biological:		ion transport transport
Cellular Component:		membrane
EC:
KOG:		[PET] Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits

Reagents	tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0	StrEns.3329.1.S1_a_at [+] StrEns.3332.1.S1_a_at
Affymetrix 2.0

Symbol legend[+]