Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (3) GO Terms (18) Nucleotides (1352) Proteins (35) Interactants (90) Wiki

Gene Symbol: ddx21

Gene Name: DEAD-box helicase 21

Synonyms: xGu-1 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: ATP-dependent RNhelicase

Protein Function :
RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds var...[+]

Interactants: Loading ...
Disease Ontology:

OMIM Diseases:

Xenbase Gene ID XB-GENE-1012547 XB-GENE-1012552 XB-GENE-17331446
Gene Symbol ddx21 ddx21.L ddx21.S
Chromosome Chr07 Scaffold124 chr7S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL TrEMBL TrEMBL Refseq Swiss-Prot Swiss-Prot Refseq Swiss-Prot Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine ddx21 ddx21.L ddx21.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards DDX21 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Ddx21 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ddx21 ZFIN Ensembl
GEISHA DDX21 Ensembl
fruit fly
First Down-regulation of RNA helicase II/Gu results in the depletion of 18 and 28 S rRNAs in Xenopus oocyte., J Biol Chem 2003  
Most Recent Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders., Nature 2018  
All View All Papers 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 13 terms 13 terms
KEGG Pathways K16911 K16911 K16911
KOG [A] ATP-dependent RNhelicase (alt_id KOG:0331)
Reagents tropicalis laevis.L laevis.S
Dharmacon Dharmacon Dharmacon
Morpholino ddx21 MO1 ddx21 MO1 ddx21 MO1
ORF ddx21.S ORF1
Affymetrix 1.0 Str.6015.3.S1_a_at Xl.9966.1.A1_at [+] Xl.7531.1.S1_at
Affymetrix 2.0 Xl2.9966.1.A1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.2

Major funding for Xenbase is provided by grant P41 HD064556