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Summary Expression Gene Literature (8) GO Terms (12) Nucleotides (256) Proteins (27) Interactants (361) Wiki
XB-GENEPAGE- 1014414

Gene Symbol: siah1

Gene Name: siah E3 ubiquitin protein ligase 1

Synonyms: seven in absentia , siah
Add Xenopus synonyms , Nomenclature history


Gene Function: zinc finger protein

Protein Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the ...[+]


Interactants: YYY

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1014415 XB-GENE-1014421 XB-GENE-17341645
Gene Symbol siah1 siah1.L siah1.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.36872 Xl.2090
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine siah1 siah1.L siah1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SIAH1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, IMPC Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN siah1 ZFIN Ensembl
chicken
GEISHA SIAH1 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. [Mol Cell 2001]
Most recent: Genome-wide identification of thyroid hormone receptor targets in the remodeling intestine during Xenopus tropicalis metamorphosis. [Sci Rep 2017]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 7 terms 0 term
EC
PANTHER siah1
KEGG Pathways K04506 K04506
KOG [R] Zn finger protein (alt_id KOG:3002)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
ORF siah1 ORF1
Affymetrix 1.0 Str.36872.1.S1_a_at [+] Xl.2090.1.S1_at
Affymetrix 2.0 Xl2.2090.1.S1_at

Symbol legend[+]

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