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Summary Expression Gene Literature (14) GO Terms (19) Nucleotides (1740) Proteins (42) Interactants (296) Wiki
Gene Symbol:

Gene Name:
cofilin 1 (non-muscle)

xac1 , xac2 , cfl1-a , cofilin-1 ( Add synonyms , Nomenclature history )

Gene Function:
actin depolymerizing factor

Protein Function :
May play a role in the regulation of cell morphology and cytoskeletal organization. Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage fu...[+]

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External Links:
Xenbase Gene ID XB-GENE-1016481 XB-GENE-1016488 XB-GENE-6251620
Gene Symbol cfl1 cfl1.L cfl1.S
Chromosome Chr04 chr4L chr4S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 407855
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine cfl1 cfl1.L cfl1.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards CFL1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Cfl1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Cfl1 Ensembl
ZFIN, AGR cfl1l ZFIN Ensembl
fruit fly
First Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development., J Cell Biol 1996                        
Most Recent Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin., Proc Natl Acad Sci U S A 2018  
All View All Papers 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 11 terms 12 terms
KEGG Pathways K05765 K05765 K05765
KOG [Z] Actin depolymerizing factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks cfl1
Antibodies Cfl1 Ab1 Cfl1 Ab1 Cfl1 Ab1
ORFs cfl1 ORF2 , cfl1 ORF1 cfl1.L ORF1 cfl1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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