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Summary Expression Gene Literature (1) GO Terms (14) Nucleotides (81) Proteins (14) Interactants (57) Wiki
XB-GENEPAGE- 1016673

Gene Symbol: usp33

Gene Name: ubiquitin specific peptidase 33

Synonyms:
Add Xenopus synonyms , Nomenclature history

Gene Function: Ubiquitin C-terminal hydrolase

Protein Function:
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Interactants: ascl1 (1) , btbd6 (1) , btg4 (1) , cdc42ep4 (1) , clcnkb (1) , cldn5 (1) , cmtm8 (1) View All

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1016674 XB-GENE-6486405 XB-GENE-17331759
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol usp33 usp33.L usp33.S
Chromosome scaffold_4 chr4L chr4S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 6.0 GBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq
Protein Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.42260 Xl.18627
RNA-seq profile: Owens, Blitz et al. 2016 usp33
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine usp33 usp33.L usp33.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
USP33 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Usp33 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN usp33 ZFIN Ensembl
chicken
GEISHA USP33 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Genomic profiling of mixer and Sox17beta targets during Xenopus endoderm development. [Dev Dyn 2006]
Most recent:
View All Papers
Functional Ontologies tropicalis laevis .L laevis.S
GO 14 terms 0 term 0 term
EC ubiquitin thiolesterase
PANTHER usp33
KEGG K11848
KOG [O] Ubiquitin C-terminal hydrolase (alt_id KOG:1870)
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Affymetrix 1.0 Str.42260.1.S2_at [+] Xl.18627.1.S1_at
Affymetrix 2.0 Xl2.18627.1.S1_at

Symbol legend[+]

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