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XB-GENEPAGE-
1032966
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Gene Symbol: ascl1
Gene Name: achaete-scute family bHLH transcription factor 1 Synonyms: ash1 , Xash1 , Mash1 Add Xenopus synonyms , Nomenclature history Gene Function: HAND2 type transcription factor Protein Function  :
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. D...[+]
Interactants: Loading ... 
Disease Ontology: CONGENITAL CENTRAL HYPOVENTILATION SYNDROME OMIM Diseases: CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS |
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1/2 | Xenbase Gene ID | XB-GENE-1032967 | XB-GENE-1032969 | XB-GENE-17340658 | ||||
| Gene Symbol | ascl1 | ascl1.L | ascl1.S | ||||
| Chromosome | Chr03 | chr3L | chr3S | ||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||
| Gene |
Genomic sequence
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Genomic sequence
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Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
NCBI Nucleotide
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Refseq
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Refseq
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| Protein
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NCBI Protein
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Refseq
Swiss-Prot
TrEMBL
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Refseq
TrEMBL
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| Genomic | tropicalis | laevis.L | laevis.S | ||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus PANTHER | ||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||
| Ensembl | Ensembl | ||||||
| UniGene | Str.44710 | Xl.450 | |||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 11 expression image(s) for tropicalis and laevis | ||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||
| XenMine | ascl1 | ascl1.L | ascl1.S | ||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||
| Smith Morpholino Screen | |||||||
| Orthology |
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| human |
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| mouse |
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| zebrafish |
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| chicken |
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| fruit fly |
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| worm |
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| Publications | |||||||
| First: | XASH1, a Xenopus homolog of achaete-scute: a proneural gene in anterior regions of the vertebrate CNS. [Mech Dev 1993] | ||||||
| Most recent: |
KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. [Development 2017]
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| View All Papers 6 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology | |||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||
| GO | 0 term | 15 terms | 3 terms | ||||
| PANTHER | ascl1 | ||||||
| KEGG Pathways | K09067 | K09067 | |||||
| KOG |
[K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
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| Reagents | tropicalis | laevis.L | laevis.S | ||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||
| Clones | EXRC - 1 clone(s) | ||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||
| Source BioScience | Source BioScience | ||||||
| Morpholino | ascl1 MO1 , ascl1 MO2 , Ascl1 MO3 , Ascl1 MO4 , ascl1 MO3 , ascl1 MO6 , ascl1 MO7 | ascl1 MO1 , ascl1 MO2 , Ascl1 MO3 , Ascl1 MO4 , ascl1 MO3 , ascl1 MO6 , ascl1 MO7 | ascl1 MO1 , ascl1 MO2 , Ascl1 MO3 , Ascl1 MO4 , ascl1 MO3 , ascl1 MO6 , ascl1 MO7 | ||||
| ORF | ascl1.S ORF1 | ||||||
| Affymetrix 1.0 | Str.23679.1.A1_at [+] | Xl.450.1.S1_at | |||||
| Affymetrix 2.0 | Xl2.450.1.S1_at | Xl2.47609.1.S1_s_at [+] | |||||
Symbol legend[+]
