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Summary Expression Gene Literature (42) GO Terms (15) Nucleotides (43) Proteins (17) Interactants (474) Wiki
XB-GENEPAGE-1032966

Gene Symbol: ascl1

Gene Name: achaete-scute family bHLH transcription factor 1

Synonyms: ash1 , Xash1 , Mash1 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: HAND2 type transcription factor

Protein Function :
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. D...[+]

Interactants: Loading ...
Disease Ontology: congenital central hypoventilation syndrome

OMIM Diseases: CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS

GEO Series: GSE76915.
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Xenbase Gene ID XB-GENE-1032967 XB-GENE-1032969 XB-GENE-17340658
Gene Symbol ascl1 ascl1.L ascl1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Swiss-Prot Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine ascl1 ascl1.L ascl1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards ASCL1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Ascl1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR ascl1b ascl1a ZFIN Ensembl
chicken
GEISHA ASCL1 Ensembl
fruit fly
worm
WORMBASE
Publications
First XASH1, a Xenopus homolog of achaete-scute: a proneural gene in anterior regions of the vertebrate CNS., Mech Dev 1993  
Most Recent KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis., Development 2017                            
All View All Papers 6 paper(s) referencing morpholinos 43 paper(s) referencing OMIMs 43 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 15 terms 3 terms
PANTHER ascl1
KEGG Pathways K09067 K09067
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Morpholino ascl1 MO1 , ascl1 MO2 , ascl1 MO3 , ascl1 MO4 , ascl1 mismatch cMO1 , ascl1 mismatch cMO2 , ascl1 MO6 , ascl1 MO7 ascl1 MO1 , ascl1 MO2 , ascl1 MO3 , ascl1 MO4 , ascl1 mismatch cMO1 , ascl1 mismatch cMO2 , ascl1 MO6 , ascl1 MO7 ascl1 MO1 , ascl1 MO2 , ascl1 MO3 , ascl1 MO4 , ascl1 mismatch cMO1 , ascl1 mismatch cMO2 , ascl1 MO6 , ascl1 MO7
ORF ascl1.S ORF1
Affymetrix 1.0 Str.23679.1.A1_at [+] Xl.450.1.S1_at
Affymetrix 2.0 Xl2.450.1.S1_at Xl2.47609.1.S1_s_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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