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Summary Expression Gene Literature (297) GO Terms (24) Nucleotides (135) Proteins (44) Interactants (768) Wiki
XB-GENEPAGE-478083
Gene Symbol:
tbx1

Gene Name:
T-box 1

Synonyms:
xtbx1 , cafs , cthm , dgcr , dorv , vcfs , tbx1c , tbx1-b , tbx1-a ( Add synonyms , Nomenclature history )

Gene Function:
T-box transcription factor

Protein Function :
Transcriptional activator involved in head and pharyngeal arch development. Induces pre-placodal ectoderm (PPE) gene expression in regions where RIPPLY3 is absent. Plays a role in the formation of the ...[+]


InterPro :
p53-like TF DNA-bd , T-box sf , TF T-box CS , TF T-box [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
DiGeorge syndrome [+]

OMIM:
CONOTRUNCAL HEART MALFORMATIONS; CTHM [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-478084 XB-GENE-478088 XB-GENE-6254396
Gene Symbol tbx1 tbx1.L tbx1.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 619587
735223
399188
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tbx1 tbx1.L tbx1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TBX1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tbx1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tbx1 Ensembl
zebrafish
ZFIN, AGR tbx1 ZFIN Ensembl
chicken
GEISHA TBX1 Ensembl
fruit fly
worm
Publications
First Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene., Genomics 1997  
Most Recent Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome., Hum Mol Genet 2020                    
All View All Papers 8 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 23 terms 9 terms 8 terms
PANTHER tbx1
KEGG Pathways K10175 K10175 K10175
KOG [K] TBX1 and related T-box transcription factors
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tbx1
Morpholinos tbx1 MO1 , tbx1 MO2 , tbx1 MO3 , tbx1 MO4 tbx1 MO1 , tbx1 MO2 , tbx1 MO3 , tbx1 MO4 tbx1 MO1 , tbx1 MO2 , tbx1 MO3 , tbx1 MO4
ORFs tbx1.L ORF1
Clones Horizon Source BioScience EXRC Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list