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Summary Expression Gene Literature (200) GO Terms (36) Nucleotides (78) Proteins (34) Interactants (376) Wiki
XB-GENEPAGE-478209
Gene Symbol:
fzd4

Gene Name:
frizzled class receptor 4

Synonyms:
Fz-4 , Xfz4 , frizzled-4 , frizzled 4 , frizzled4 , Fz4 ( Add synonyms , Nomenclature history )

Gene Function:
transmembrane receptor in the wnt signaling pathway

Protein Function :
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear...[+]



Interactants:
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Diseases: 


Disease Ontology:
exudative vitreoretinopathy [+]

OMIM:
EXUDATIVE VITREORETINOPATHY 1; EVR1

External Links:
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Xenbase Gene ID XB-GENE-478210 XB-GENE-17342547 XB-GENE-865153
Gene Symbol fzd4 fzd4.L fzd4.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100497693
399192
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fzd4 fzd4.L fzd4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FZD4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fzd4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fzd4 Ensembl
zebrafish
ZFIN, AGR fzd4 ZFIN Ensembl
chicken
GEISHA FZD4 Ensembl
fruit fly
worm
Publications
First Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm., Mech Dev 2000    
Most Recent eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., J Biol Chem 2020            
All View All Papers 2 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 12 terms 0 term 32 terms
PANTHER fzd4
KEGG Pathways K02354 K02354
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fzd4
Morpholinos Fzd4 MO1 Fzd4 MO1 Fzd4 MO1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list