|
XB-GENEPAGE-478671
Gene Symbol:
irs1
Gene Name: insulin receptor substrate 1
Synonyms:
irs-1
( Gene Function: exo-a-sialidase Protein Function
![]()
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidyl...[+]
Interactants:
Loading ...
Diseases: Disease Ontology:
type 2 diabetes mellitus
OMIM:
TYPE 2 DIABETES MELLITUS; T2D
External Links:
|
|
Xenbase Gene ID | XB-GENE-478672 | XB-GENE-478676 | XB-GENE-17338071 | |||||
Gene Symbol | irs1 | irs1.L | irs1.S | Chromosome | Chr5 | chr5L | chr5S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
![]() |
Version 9.1
![]() |
Version 9.1
![]() |
|||||
CDS |
Gene model
![]() |
Gene model
![]() |
||||||
Entrez Gene |
100495320
|
399299
|
||||||
mRNA |
NCBI Nucleotide
![]() ![]() |
NCBI Nucleotide
![]() ![]() |
||||||
Protein
![]() |
![]() ![]() ![]() ![]() |
![]() ![]() ![]() ![]() |
||||||
Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser) |
||||||||
Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
|
|||||||
More Information |
|
|||||||
Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Embryonic Protein Expression | Stage profile:![]() |
|||||||
Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | irs1 | irs1.L | irs1.S | |||||
Orthology |
|
|||||||
human |
|
|||||||
mouse |
|
|||||||
rat |
|
|||||||
zebrafish |
|
|||||||
chicken |
|
|||||||
fruit fly |
|
|||||||
worm |
|
|||||||
Publications | ||||||||
First |
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains., Diabetes 1993 |
|||||||
Most Recent |
Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Peptides 2020 |
|||||||
All | View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 11 terms | 9 terms | 0 term | |||||
PANTHER | irs1 | |||||||
KEGG Pathways | K16172 | K16172 | ||||||
KOG |
[Y] Nucleolar GTPase/ATPase p130
|
|||||||
Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | irs1 | |||||||
Morpholinos | irs1 MO1 , irs1 MO2 | irs1 MO1 , irs1 MO2 | irs1 MO1 , irs1 MO2 | |||||
Clones | Horizon Source BioScience | Horizon Source BioScience | ||||||
Plasmids | Addgene | Addgene |
Symbol legend:



