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Summary Expression Gene Literature (14) GO Terms (13) Nucleotides (110) Proteins (14) Interactants (167) Wiki
XB-GENEPAGE-478671

Gene Symbol: irs1

Gene Name: insulin receptor substrate 1

Synonyms: irs-1 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: exo-a-sialidase

Protein Function :
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidyl...[+]

Interactants: Loading ...
Disease Ontology: type 2 diabetes mellitus

OMIM Diseases: DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM [+]

 
Xenbase Gene ID XB-GENE-478672 XB-GENE-478676 XB-GENE-17338071
Gene Symbol irs1 irs1.L irs1.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein TrEMBL Refseq Swiss-Prot Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine irs1 irs1.L irs1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
IRS1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Irs1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
irs1 ZFIN Ensembl
chicken
GEISHA IRS1 Ensembl
fruit fly
worm
WORMBASE
Publications
First The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains., Diabetes 1993  
Most Recent Metabolic and immune impairments induced by the endocrine disruptors benzo[a]pyrene and triclosan in Xenopus tropicalis., Chemosphere 2016  
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 10 terms 0 term
PANTHER irs1
KEGG Pathways K16172
KOG [Y] Nucleolar GTPase/ATPase p130
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Morpholino irs1 MO1 , irs1 MO2 irs1 MO1 , irs1 MO2 irs1 MO1 , irs1 MO2
Affymetrix 1.0 Str.30203.1.A1_at [+] Xl.957.1.S1_at [+]
Affymetrix 2.0 Xl2.957.1.S2_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.11.2


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