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Summary Expression Gene Literature (94) GO Terms (16) Nucleotides (124) Proteins (24) Interactants (177) Wiki
XB-GENEPAGE-478671
Gene Symbol:
irs1

Gene Name:
insulin receptor substrate 1

Synonyms:
irs-1 ( Add synonyms , Nomenclature history )

Gene Function:
exo-a-sialidase

Protein Function :
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidyl...[+]


InterPro :
IRS PTB , PH domain , PH-like dom sf , IRS [+]

Interactants:
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Diseases: 


Disease Ontology:
type 2 diabetes mellitus

OMIM:
TYPE 2 DIABETES MELLITUS; T2D [+]

External Links:
 
Xenbase Gene ID XB-GENE-478672 XB-GENE-478676 XB-GENE-17338071
Gene Symbol irs1 irs1.L irs1.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100495320
399299
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irs1 irs1.L irs1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, IRS1 Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irs1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irs1 Ensembl
zebrafish
irs1 Ensembl
chicken
GEISHA IRS1 Ensembl
fruit fly
worm
Publications
First The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains., Diabetes 1993  
Most Recent Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Peptides 2020  
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 9 terms 0 term
PANTHER irs1
KEGG Pathways K16172 K16172
KOG [Y] Nucleolar GTPase/ATPase p130
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irs1
Morpholinos irs1 MO1 , irs1 MO2 irs1 MO1 , irs1 MO2 irs1 MO1 , irs1 MO2
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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