map2k1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

My Xenbase
[Login] [Register]

Search

Summary

Gene Literature (32)

Nucleotides (313)

Interactants (100)

XB-GENEPAGE-478821

Gene Symbol: map2k1 Gene Name: mitogen-activated protein kinase kinase 1 Synonyms: mek1 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: mapk1(27) , mos(9) , raf1(8) , rps6ka3(7) , cdk1(6) , pold1(6) , rps6ka1(6) View All

XB-GENE-478822

XB-GENE-865216

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001008057\|Xenopus (Silurana) tropicalis mitogen-activated protein kinase kinase 1 (map2k1), mRNA GGCTGCCGTATTACTGCCAGGGTCCGGGGATAGCGCTACTCACTGCCAGCCACAGGGGCCCCGCTCTGCTCTTAACTCACTCCCAAAATGCCTAAGAAGAAGCCTACGCCCATACAGCTGAACCCCAACCCTGAGGGGACTGCTGTGAACGGAACCCCTACAGCCGAGACAAACCTTGAAGCTCTGCAGAAAAAGTTGGAAGAGCTGGAGCTGGATGAGCAGCAGAGGAAGCGTCTAGAGGCCTTTCTCACCCAGAAGCAGAAAGTTGGGGAGCTGAAGGATGATGACTTTGAGAAAGTGTCGGAGCTTGGAGCAGGCAATGGAGGAGTGGTGTTTAAGGTGTCCCACAAGCCGACTAGCTTGATTATGGCCAGGAAGTTAATTCATCTGGAGATAAAGCCTGCAATCAGAAATCAGATTATCCGAGAGTTGCAGGTTCTGCATGAATGTAACTCCCCATACATTGTGGGGTTCTATGGGGCCTTCTACAGTGACGGAGAGATCAGCATTTGTATGGAACACATGGATGGAGGCTCCCTTGATCAGGTTTTGAAGAAAGCTGGCAAAATCCCTGAGAAAATTTTGGGAAAAGTCAGCATTGCAGTGATAAAAGGTCTAACCTACCTGAGAGAGAAGCATAAGATAATGCACAGAGATGTGAAACCTTCTAACATCCTAGTCAACTCTAGGGGAGAGATAAAACTCTGCGACTTTGGAGTCAGCGGGCAGCTAATAGACTCCATGGCAAATTCCTTTGTTGGGACAAGATCCTATATGTCACCGGAGCGGCTACAGGGCACTCATTATTCTGTGCAATCTGACATCTGGAGCATGGGGCTGTCACTTGTGGAAATGGCCATAGGAAGGTATCCCATTCCACCACCTGATGCCAAAGAACTGGAACTTATCTTTGGGTGTTCTGTAGAAGGGGACCCGGCATCTTCTGAACTGGCGCCTCGCCCCCGGCCACCTGGACGTCCAATCAGTTCTTATGGTCCTGATAGTCGACCACCAATGGCCATTTTTGAGCTTCTGGATTATATAGTGAACGAGCCACCTCCAAAATTGCCCAGTGGAGTATTTGGAGCTGAGTTCCAGGACTTTGTGAATAAATGTCTTGTGAAGAATCCAGCAGAGAGAGCAGATCTTAAACAGCTAATGGTTCACAGCTTCATTAAGCAGTCAGAGTTGGAGGAGGTGGATTTTGCTGGATGGCTTTGTTCCACTATGGGTCTTAAACAGCCCAGTACCCCAACCCATGCCGCTGGAGTGTGAGTGAACATGGCGTGGATGGTGGGCCTGGCAGAGAGTTACCACATCATGCTCATGCCAACCTCTGAGGTTGGGGTCTCTGCAGAAAGTGCCAAAAACATTCTTTTAATTCTCTTCAATCCCTTCATTGAGTTGGGTCCTTTTTGGGAATGGGATGAACATGATTTATTCCAGTGTCCTGTGGGCTCCACTTGCAGTATGGTTCCTGCTTTTATCCCCATGATGCTTTGTGGTACCTGTGATGCTTTCAGTACATGATACAGGAGATGAGCCCAGTCTGTGTTTGGGAGGTGACAGGACTGTGCATTCTGATTTACCAGCAAAATGCATACTAGGCCAGTCGCAGGGTAGACCAAACTGAACTGATGGCTGTTATTTACATAACTGGATGGATGATGACAAAATGTCAGGAAGAAGGCAAAACCAGTTAAAAGTAACGGTTAATAAAAGCTTTAGAAGCAAATCTCAAGAAAGACCTAATGACACTTCTATCATATCAATTATGCAGTGCTAAATGAATTACAAAAAGGTCAGTTTTAACACTTCCCTTGTTAGAAAGAAATAACCTACTGTGCTTAGTTCATGTTGGTCGCACATGAGACTGCACCCCCACCCCCCAAAAAAAAAATTTGGATACTCGTACGCTGTCTGGAGATCTGAGCCATGCATGTTCCTTGCAGGCAGATGTCTGTATCTGAACCTGCGTCCAAAGCCATAAGCCCAGGGCCTGTCAGCTTTAAGAAATGGCCAGTTATGGGAAATGAATTGTGGGAACGTTAACCCATCTCTGCCGGAGCATTTCTATTAAATTGAGCACGTATCACTTGGTGTCTAATTCCTCTAATTGTGGAGGTATGAGGGTGGGTGGGGGAAATGTTGAGTGTAGTGCAATGTGTAAGATTGATGAGGGTAATGGGAAAGGATTTAGGGAATTACTGCAGTTCAAAATCATTGCAAACCATGAATCCATACAGGTTGCTCCGGCAGAGAGCGGGATAGCTAGCCAGCAGTCCTTCCGCTGCCTCCTGCCTGTGCCTCTTTGCTTGCTCTGATTCTTTCATATTTATTTTTTATTTGAATGTGATGTGCTGTGTGAGCTGTGGATCTGCTCGCTGTATAGGGCTTCTTTCCCTCCATGGAATTATTTTTCCTGCGTTCCCTTTCCCTTATTGCAACATCTGCAACATGCCAAGGGGAAAAGCTTACCCTAGAGCAGAATTCCTGACCGTGAGAAGCATTTGCCTTTAGTCTCTGAACATTGTATCTTTTGAGTCTTCAGATGTGTTATCTTTGATTCTAATAAATATGTTCTAGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001086830\|Xenopus laevis mitogen-activated protein kinase kinase 1 (map2k1), mRNA GAGTGACAGTCCGCTGTAGAACACTGCCAGGGTCTGGGATATAGCGCTACTCACTGCCAAGCACAGGGGCACTCGCTCTGCTCTCCACTCACTCCCAACATGCCTAAAAAGAAGCCTACGCCCATACAGCTGAATCCCAACCCCGAAGGGACTGCTGTGAACGGGACCCCTACAGCCGAGACAAACCTTGAAGCTCTGCAGAAAAAGTTGGAAGAGCTTGAGCTGGATGAGCAGCAGAGGAAGCGTCTGGAGGCTTTTCTCACCCAGAAGCAGAAAGTTGGGGAACTGAAGGATGACGACTTTGAAAAAGTTTCAGAGCTTGGAGCAGGCAACGGAGGAGTGGTGTTTAAGGTGTCCCACAAGCCAACCAGCTTGATTATGGCCAGGAAGTTGATTCATCTGGAGATTAAGCCTGCAATCCGAAACCAGATTATCCGAGAGTTGCAGGTTCTGCATGAATGTAACTCCCCATACATTGTGGGGTTCTATGGGGCCTTCTACAGTGATGGAGAGATCAGCATTTGCATGGAACACATGGATGGAGGCTCCCTTGATCAGGTTCTGAAGAAAGCTGGCAAAATCCCAGAAAAGATTTTGGGAAAAGTCAGCATTGCAGTGATAAAAGGTCTAACCTACCTGAGAGAAAAGCATAAGATAATGCACAGAGATGTGAAACCTTCTAACATCCTGGTCAACTCTAGAGGAGAGATAAAACTCTGCGACTTTGGGGTCAGCGGGCAACTCATAGACTCCATGGCAAATTCCTTTGTTGGGACAAGATCCTATATGTCACCGGAGCGACTACAGGGCACTCATTATTCTGTGCAATCAGACATCTGGAGCATGGGGCTGTCGCTGGTGGAAATGGCCATTGGAAGGTATCCCATTCCACCCCCTGATGCCAAAGAGCTGGAACTTATCTTTGGGTGTTCTGTAGAAAGGGATCCAGCATCTTCTGAACTGGCACCTCGCCCCCGGCCACCCGGACGTCCAATAAGCTCATACGGTCCTGATAGTCGACCACCCATGGCTATTTTTGAACTTCTGGATTATATCGTGAACGAGCCGCCTCCAAAATTGCCCAGTGGAGTATTTGGAGCTGAGTTCCAGGACTTTGTGAATAAATGTCTTGTGAAGAATCCGGCAGAGAGAGCAGACCTTAAACAGCTAATGGTTCACAGCTTCATTAAGCAGTCAGAGTTGGAGGAAGTGGATTTTGCTGGATGGCTCTGTTCCACTATGGGCCTTAAGCAGCCCAGTACCCCAACCCATGCCGCCGGAGTGTGAGTGAACATGGCGTGGATGGTGGGCCTGGCAGAGAGTTACCACATCATGCTCATACCAACCTCTATGGTTGGGGTCTCTGCAGAAAGTGCCAAAAACATTCTTTTAATTCTCTTCAATCCCTTCATTGAGTTGGGTCCTTTTGGGAATGGGATAAACACGATTTATTCCAGTGTCCTGTGGGCTCCACTTGCAGTACAGTTCCTGCTTTTATCCCATGATGCTTTGTGGTACCTGTGATGCTTTCAGTACACGATACAGGAGATGAGCCCAGGTGATAGGTGACTGTGCATTCTGATTTACCAGCAAAATGCATACTAGGTCAGTCACAGGCCAAACTGAACTGATGGCTGTTATGTACCAAACTGGATGGATGATGACACATGTCAGGAAAAAGGCAAAACCAGTTAAAAGTAATGGTTAAAAAAGGCTTTATAAGCAAATGGCAAGACAGACCTATCATATCAATAATGCAGTGCAGGCTAAATTTATTGCAAAGAATCCGTTTTAACACTTCCCTTATTCTCAAGAAATGCCCTACTGCGCTTAGTTCATGTTGGTCACACATGAGACTGCCCCAACCTCCCAAAATTAGGATTCTCATATGCTGTCTGGAGATCTGAGCCATGCATGTTCCTTGCAGGCAGATGTCTGTATCTGAACCTGCGTCCAAAGCCATAAGCCCAGGGCCTGCCAGCTATAAGAAATGGTCAGTTATGGGAAATGAATTGTGGAAATGTTAACCCATCTCTGCCGGAGCACTTCTATTAAGTGGAGCACATACTGTATATCACTTGATGTCTTTCTTAAATTGGAGATGAGTGGGGGCAAATGTTAAGTATAGGGCAGTTTGAACATATATGTTAGATGTATGAGGGTAATGGGAAAGGATTTATAGATTTGTTGCAGTTTGAAAGCATAACAAACCATGAATCCATACAGGTTGCTCCGGCAGAGAACGGGATAGCTAGCCAGCAGTCCTTCCGCTGCCTCCTGCCTGTGCCTCTTTGCTTGCTCTGATTCTTTCATATTTATTTTTTATTTGAATGTGATGTGCTGTGTGAGCTGTGGATCTGCTCGCTGTATAGGGCTTCTTTCCCTCCATGGAATTATTTTTCCTGCGTTCCCTTTCCCTTATTGCAACATCTCCAACATGCCAAGGGGAAAAGCTTTACCCCAGAGCAGAATTCCTGACCGTGAGAAGCCGTTGCCTTTAGTCTCTCAACATTGTATCTTTCGAGTATTCAGATGTGTTATCTTTGATTCTAATAAATATGTTCTAGAGAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001008058\|mitogen-activated protein kinase kinase 1 [Xenopus (Silurana) tropicalis] MPKKKPTPIQLNPNPEGTAVNGTPTAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLMVHSFIKQSELEEVDFAGWLCSTMGLKQPSTPTHAAGV	Refseq >NP_001080299\|dual specificity mitogen-activated protein kinase kinase 1 [Xenopus laevis] MPKKKPTPIQLNPNPEGTAVNGTPTAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVERDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLMVHSFIKQSELEEVDFAGWLCSTMGLKQPSTPTHAAGV UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.50744	Xl.5877
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	MAP2K1
mouse		MGI	Map2k1	All(4) Gene Trapped(2) Targeted, knock Out(1) Targeted, other(1)
zebrafish		ZFIN	map2k1

Publications
First:		MAP kinase-dependent pathways in cell cycle control. [Prog Cell Cycle Res 1995]
Most recent:		Coregulation of multiple signaling mechanisms in pp60v-Src-induced closure of Cx43 gap junction channels. [J Membr Biol 2012]
		View All Papers 2 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Mitogen-activated protein kinase kinase (MAP2K)

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.10686.1.S1_a_at [+] Str.50744.2.A1_x_at Str.50744.1.A1_x_at	Xl.5877.1.S1_at
Affymetrix 2.0			Xl2.5877.1.S1_at

Symbol legend[+]