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Summary Expression Gene Literature (21) GO Terms (6) Nucleotides (139) Proteins (19) Interactants (131) Wiki
XB-GENEPAGE- 478929

Gene Symbol: tll2

Gene Name: tolloid like 2

Synonyms: xolloid , Xld
Add Xenopus synonyms , Nomenclature history


Gene Function: metalloprotease

Protein Function:
Protease which specifically processes prolysyl oxidase and maybe also chordin. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterni...[+]


Interactants: Loading ...

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-478930 XB-GENE-478934 XB-GENE-17336748
Gene Symbol tll2 tll2.L tll2.S
Chromosome scaffold_8 chr7L
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.2221 [+] Xl.36
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 1 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine tll2 tll2.L tll2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards TLL2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Tll2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN
chicken
GEISHA TLL2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. [Cell 1997]
Most recent: Genomic organization and modulation of gene expression of the TGF-β and FGF pathways in the allotetraploid frog Xenopus laevis. [Dev Biol 2017]
View All Papers 3 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 6 terms 0 term
EC procollagen C-endopeptidase
PANTHER tll2
KEGG Pathways K13047
KOG [O] Meprin A metalloprotease
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)    
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino tll2 MO1 tll2 MO1 tll2 MO1
Affymetrix 1.0 StrJgi.2431.1.S1_s_at [+] Xl.36.1.S1_at
Affymetrix 2.0 Xl2.36.1.S1_at

Symbol legend[+]

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