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Summary Expression Gene Literature (78) GO Terms (22) Nucleotides (130) Proteins (46) Interactants (1046) Wiki
XB-GENEPAGE-479254
Gene Symbol:
fgfr3

Gene Name:
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

Synonyms:
ach , cek2 , jtk4 , cd333 , hsfgfr3ex , fgfr-3 ( Add synonyms , Nomenclature history )

Gene Function:
receptor tyrosine kinase

Protein Function :
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an ess...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
LADD syndrome [+]

OMIM:
ACHONDROPLASIA; ACH [+]

External Links:
 
Xenbase Gene ID XB-GENE-479255 XB-GENE-479259 XB-GENE-17330101
Gene Symbol fgfr3 fgfr3.L fgfr3.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100196923
779370
399347
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fgfr3 fgfr3.L fgfr3.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tgas092f08      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FGFR3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fgfr3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fgfr3 Ensembl
zebrafish
ZFIN, AGR fgfr3 ZFIN Ensembl
chicken
GEISHA FGFR3 Ensembl
fruit fly
worm
Publications
First Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2., J Biol Chem 1995  
Most Recent The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism., eNeuro 2019                    
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 20 terms 6 terms 6 terms
PANTHER fgfr3
KEGG Pathways K05094 K05094 K05094
KOG [T] Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fgfr3
Morpholinos fgfr3 MO1 , fgfr3 MO2 fgfr3 MO1 , fgfr3 MO2 fgfr3 MO1 , fgfr3 MO2
ORFs fgfr3.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list