Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (23) GO Terms (20) Nucleotides (31) Proteins (17) Interactants (178) Wiki
XB-GENEPAGE-480185
Gene Symbol:
il6

Gene Name:
interleukin 6

Synonyms:
il-6 , interleukin-6 ( Add synonyms , Nomenclature history )

Gene Function:
cytokine

Protein Function :


InterPro :
Rho GTPase activation prot , RhoGAP dom , DH-domain , DBL dom sf [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
arteriovenous malformations of the brain [+]

OMIM:
DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM [+]

External Links:
 
Xenbase Gene ID XB-GENE-480186 XB-GENE-17342859 XB-GENE-6489373
Gene Symbol il6 il6.L il6.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100493927
108718487
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine il6 il6.L il6.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IL6 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Il6 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Il6 Ensembl
zebrafish
ZFIN, AGR il6 ZFIN Ensembl
chicken
GEISHA IL6 Ensembl
fruit fly
worm
Publications
First Recombinant soluble Fc epsilon receptor II (Fc epsilon RII/CD23) has IgE binding activity but no B cell growth promoting activity., J Immunol 1989  
Most Recent The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation., Development 2020                                      
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 20 terms 0 term 0 term
PANTHER il6
KEGG Pathways
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks il6
Clones Horizon Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.16.0
Major funding for Xenbase is provided by grant P41 HD064556