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Summary Expression Gene Literature (29) GO Terms (26) Nucleotides (147) Proteins (28) Interactants (326) Wiki
XB-GENEPAGE- 480485

Gene Symbol: irx3

Gene Name: iroquois homeobox 3

Synonyms: xiro3 , mgc131103 , xiro-3 , irx3b
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor

Protein Function:
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates an...[+]


Interactants: YYY

OMIM Disease Associations:
1/9
 
Xenbase Gene ID XB-GENE-480486 XB-GENE-480490 XB-GENE-17335664
Gene Symbol irx3 irx3.L irx3.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq NCBI Nucleotide
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.51982 Xl.4522 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 53 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine irx3 irx3.L irx3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
IRX3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Irx3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN irx3a irx3b ZFIN Ensembl
chicken
GEISHA IRX3 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. [EMBO J 1998]
Most recent: Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation. [Dev Biol 2017]
View All Papers 9 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 23 terms 3 terms
EC
PANTHER irx3
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s) EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino irx3 MO1 , irx3 MO2 , Irx3 MO3 , Irx3 MO4 , irx3 MO5 irx3 MO1 , irx3 MO2 , Irx3 MO3 , Irx3 MO4 , irx3 MO5 irx3 MO1 , irx3 MO2 , Irx3 MO3 , Irx3 MO4 , irx3 MO5
ORF irx3 ORF1
Affymetrix 1.0 Str.2093.1.S1_at [+] Xl.4522.1.S1_at
Affymetrix 2.0 Xl2.53935.1.S1_x_at [+] Xl2.53935.1.S1_x_at [+]

Symbol legend[+]

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