Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (145) GO Terms (17) Nucleotides (41) Proteins (29) Interactants (973) Wiki
Gene Symbol: fgf4

Gene Name: fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)

Synonyms: efgf , HBGF-4 , XEFGF , fgfe , fgf-4 , Xfgf4 , Xfgf-4 , fgf4-b , fgf4-a ( Add synonyms , Nomenclature history )

Gene Function: heparin-binding growth factor

Protein Function :
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Good candidate for an inducing factor with possible roles both in mesoderm induction at...[+]

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-480496 XB-GENE-6252641 XB-GENE-865382
Gene Symbol fgf4 fgf4.L fgf4.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100217325
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL TrEMBL TrEMBL TrEMBL RefSeq Swiss-Prot RefSeq TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine fgf4 fgf4.L fgf4.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards FGF4 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Fgf4 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR fgf4 ZFIN Ensembl
fruit fly
First Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF., Development 1989  
Most Recent Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis., Cell Rep 2020                  
All View All Papers 29 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 13 terms 7 terms 7 terms
KEGG Pathways K04358 K04358 K04358
KOG [T] Fibroblast growth factor
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks fgf4
Morpholinos fgf4 MO1 fgf4 MO1 fgf4 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.13.1
Major funding for Xenbase is provided by grant P41 HD064556