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Summary Expression Gene Literature (12) GO Terms (19) Nucleotides (68) Proteins (38) Interactants (187) Wiki
XB-GENEPAGE-480569
Gene Symbol:
irx4

Gene Name:
iroquois homeobox 4

Synonyms:
iroquois-4 , irxa3 , Xiro4 , irx4-a , irx4-b ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroec...[+]


InterPro :
EGF-like dom , cEGF , EGF Ca-bd CS , EGF-type Asp/Asn hydroxyl site [+]

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-480570 XB-GENE-865388 XB-GENE-6448215
Gene Symbol irx4 irx4.L irx4.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038068
779102
100301956
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irx4 irx4.L irx4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IRX4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irx4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irx4 Ensembl
zebrafish
chicken
GEISHA IRX4 Ensembl
fruit fly
worm
Publications
First Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand., Dev Biol 2000    
Most Recent Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis., Dev Biol 2017                
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 15 terms 11 terms 8 terms
PANTHER irx4
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irx4
Morpholinos (on-target & off-target) irx4 MO1 irx4 MO1 irx4 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info