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Summary Expression Gene Literature (14) GO Terms (51) Nucleotides (158) Proteins (41) Interactants (455) Wiki
XB-GENEPAGE-480854
Gene Symbol:
apc

Gene Name:
adenomatous polyposis coli

Synonyms:
xapc ( Add synonyms , Nomenclature history )

Gene Function:
tumor suppressor

Protein Function :
Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
familial adenomatous polyposis [+]

OMIM:
MEDULLOBLASTOMA; MDB [+]

External Links:
1/4
 
Xenbase Gene ID XB-GENE-480855 XB-GENE-480859 XB-GENE-17331559
Gene Symbol apc apc.L apc.S
Chromosome Chr01 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 779466
399455
108707215
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine apc apc.L apc.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards APC OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Apc MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Apc Ensembl
zebrafish
ZFIN, AGR apc ZFIN Ensembl
chicken
GEISHA APC Ensembl
fruit fly
FLYBASE Apc Ensembl
worm
Publications
First Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis., J Cell Biol 1997              
Most Recent Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles., Sci Rep 2020                    
All View All Papers 1 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 45 terms 19 terms 13 terms
PANTHER apc
KEGG Pathways K02085 K02085
KOG [TZ] Beta-catenin-binding protein APC, contains ARM repeats
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks apc
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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