dkk1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (94)

Nucleotides (100)

Interactants (369)

XB-GENEPAGE-481643

Gene Symbol: dkk1 Gene Name: dickkopf WNT signaling pathway inhibitor 1 Synonyms: dickkopf-1, Xdkk-1, dkk-1, dkk, xdkk1, Dickkopf1 Add Xenopus synonyms Gene Function: secreted wnt antagonist Interactants: wnt8a(25) , chrd(19) , wnt3a(19) , bmp4(18) , otx2(16) , nog(15) , cer1(14) View All

XB-GENE-481644

XB-GENE-865473

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001016283\|Xenopus (Silurana) tropicalis dickkopf 1 (dkk1), mRNA CGCAGCAGTCACAACCGGCGCTGCACCCAAGCCTTCAGCAGCACCCAAGCACCCTAGCCATCAGCAGCACCCAAGTCTTCAGCAGCACCCAAGGGACTTATCCCCGGAGGACTTATCCTGCCGTTATTGGTTACTGGGACAGAGGAATGGACGAGATGTTCCTGATGCTTCTTTTTGCCTTGGGGGGGTTTATCTTGGATGGGGCACTTGGCTTTGTCATGATGACCAACTCCAACTCCATCAAGAACGTCCCAGCGGCCCCGGCTGGGCAACCCATTGGCTACTACCCTGTCAGTGTCAGTCCGGACTCCTTATATGATATTGCCAACAAATACCAACCTTTGGATGCCTACCCGCTCTACGGTTGCACAGAAGATGACGACTGTGCCCTGGATGAGTTCTGCCACAGTTCCAGAAATGGCAACTCCCTGGTCTGCTTGGCATGCCGGAAACGCCGCAAGCGCTGCCTGAGGGACGCAATGTGCTGCACCGGCAACTACTGTAGCAACGGAATATGTGTCCCCGTGGAGCAAGATCAAGAGCGCTTCCAGCAGCAGGGATACCTGGAGGAAACCATTCTGGAAAACTATAACGCCGATCACGCAACAATGGATACGCATTCAAAATTAACCACGTCCCCTTCGGGAATGCAGCCCTTTAAAGGTCGTGATGGTGACGTCTGCCTCAGATCAACCGACTGCGCCCCAGGTCTATGCTGCGCCCGTCACTTCTGGTCGAAGATCTGCAAGCCGGTGCTTGAGGAAGGCCAAGTGTGCACCAAGCACAGGAGGAAAGGCTCCCACGGGCTGGAGATCTTCCAGCGTTGCCACTGCGGCGCCGGACTCTCCTGTCGGTTACAGAAGGGAGAGTTTACGACCGTCCCTAAGACCTCGAGACTTCACACTTGCCAGAGACACTAAGTGAGGCCTGCAGAGCCTGAAGGACCTTCTCTAAATTAAGCTAATAAGGACATTGGCCGCTAATAAGGACATTGGCCGCTAATAAGGACATTGGTCGCTCTGCCTTTGGGGGCGTATCAGTTTACATGAAGTGCTCTGGTCCCTCCCCCCCCCGAGCCCAGAGCTGCACAACTTGTTTCTTTTTTATAGGAACTTCTTATTAATTCCTAATTACAGTAAATTACTGTGTTGTAAATTGGTTAATAATGATGAACAGCTGTAAATATCTGTGTATAGAAAATGTACATGATCCTCTCTATTGTAACCGGCCGCCTTGTACATTCCGACTCGCTCTTCCCTGTTTATATATAAATATATCTATATAAATATTATGTAGATTTTAACGTCTAGTACGTCTGTATTTCTAATTGAAATAAAACATTTCCAAACCGAAAAAAAAAAAAAAAAAA	Refseq >NM_001085592\|Xenopus laevis dickkopf 1 (dkk1), mRNA GACAGTCGGAGCCGGCGCTGCAGCATCAAAGGGACTTATCTTGGAGGACTTGTGAATTCTCATCCTGCCATTGTGGTTACTGAGTCTGGTTGGACAGAGGAATGGGCAGCAACATGTTCCCGGTGCCTCTTATTGTCTTTTGGGGTTTTATCTTGGATGGGGCACTTGGCTTTGTCATGATGACCAACTCCAACTCCATCAAGAATGTGCCGGCGGCACCAGCAGGTCAGCCCATTGGCTACTACCCTGTGAGCGTCAGTCCGGACTCCCTATATGATATTGCCAACAAGTACCAACCTCTGGATGCCTACCCGCTCTACAGTTGCACGGAAGATGATGACTGTGCCCTTGATGAATTCTGTCACAGTTCCAGAAACGGCAACTCTCTGGTTTGCTTGGCATGCCGGAAACGCAGAAAGCGTTGCCTGAGGGACGCCATGTGCTGCACAGGCAACTACTGTAGCAACGGAATTTGTGTCCCTGTGGAGCAAGATCAAGAGCGCTTCCAACACCAGGGATACCTGGAAGAAACCATTCTGGAAAACTATAATAATGCTGATCATGCAACAATGGATACTCATTCCAAATTAACCACGTCCCCATCTGGAATGCAGCCCTTTAAAGGCCGTGATGGTGATGTTTGCCTCCGATCAACTGACTGTGCGCCAGGTCTATGCTGTGCCCGTCATTTCTGGTCAAAGATCTGCAAGCCGGTCCTTGATGAAGGCCAAGTGTGCACCAAGCACAGGAGGAAAGGCTCTCACGGGCTAGAGATTTTCCAGCGTTGTCACTGCGGTGCCGGACTCTCGTGCCGGTTACAGAAAGGAGAATTTACAACTGTCCCTAAAACATCGAGACTTCACACTTGCCAAAGACACTAAGCGAGGCCTACAGAGCCTGAAGGACCTTCTCTAAATTAAGCTAATTAAGACTTTGGTACCTGCATGTTATTTTCTCAGTTTACATGAAGTGCTCTGGTCTTCCCTGAACCCGGAAGCTGCGCAACTTGTTTCTTTTTTTGAGGAACTTCCTAATTAATGCTAATTACAGTAAATTACTGTGTTGTAAATACTACGCAAGGAGACCTGTAAAAACTGTAAATACCCGTGTATAGAAAGTGTACATGATCTTCTCTATTGTAACCTGCCACCTTGTACATTCCGACGCGCTCTTCCCTTTTTATATATATATATATATAAATATATATTATATTATGTAGAGTTTACGTCTAGTATGTCTGTATTTTTAATTGAAATAAAACATTTCTAAACTTAAAAACAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001016283\|dickkopf 1 precursor [Xenopus (Silurana) tropicalis] MDEMFLMLLFALGGFILDGALGFVMMTNSNSIKNVPAAPAGQPIGYYPVSVSPDSLYDIANKYQPLDAYPLYGCTEDDDCALDEFCHSSRNGNSLVCLACRKRRKRCLRDAMCCTGNYCSNGICVPVEQDQERFQQQGYLEETILENYNADHATMDTHSKLTTSPSGMQPFKGRDGDVCLRSTDCAPGLCCARHFWSKICKPVLEEGQVCTKHRRKGSHGLEIFQRCHCGAGLSCRLQKGEFTTVPKTSRLHTCQRH	Refseq >NP_001079061\|dickkopf 1 precursor [Xenopus laevis] MGSNMFPVPLIVFWGFILDGALGFVMMTNSNSIKNVPAAPAGQPIGYYPVSVSPDSLYDIANKYQPLDAYPLYSCTEDDDCALDEFCHSSRNGNSLVCLACRKRRKRCLRDAMCCTGNYCSNGICVPVEQDQERFQHQGYLEETILENYNNADHATMDTHSKLTTSPSGMQPFKGRDGDVCLRSTDCAPGLCCARHFWSKICKPVLDEGQVCTKHRRKGSHGLEIFQRCHCGAGLSCRLQKGEFTTVPKTSRLHTCQRH

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.15023 [+] Str.29937	Xl.251
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		19 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	DKK1
mouse		MGI	Dkk1	All(6) Targeted, knock Out(1) Targeted, other(3)
zebrafish		ZFIN ZFIN	dkk1b dkk1a

Publications
First:		Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. [Nature 1998]
Most recent:		Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. [Development 2012]
		View All Papers 20 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		multicellular organismal development negative regulation of Wnt receptor signaling pathway
Cellular Component:		extracellular region
EC:
KOG:		[T] Proteins containing Ca2+-binding EGF-like domains

Reagents		tropicalis	laevis
Clones		EXRC - 1 clone(s)	EXRC - 2 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.15023.1.S1_a_at [+] Str.15023.1.S1_at Str.29937.1.S1_at	Xl.251.1.S1_at
Affymetrix 2.0			Xl2.251.1.S1_at [+] Xl2.10134.1.A1_at

Symbol legend[+]