Gene Symbol: il1b Gene Name: interleukin 1, beta Synonyms: IL-1B, interleukin-1-beta, IL-1 Add Xenopus synonyms Gene Function: cytokine Interactants: il6(2) , irak1(2) , myd88(2) , nfkb1(2) , rel(2) , tnf(2) , akt1(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932572|PREDICTED: Xenopus (Silurana) tropicalis interleukin-1 beta-like (LOC100487038), mRNA ATGGCATTGGTTCCCGACTTGAGTTCCATTCCCATGGAGAGCTGCAGTGGGGACGATGAAATGTTTTACAGTGACAGCCCACCAGGAATGAAGGATTCCATGAAAGATGATTCTCAGTGGCACTCACACCCCGGCCATTGCTCCCAATACAACCTGGATATCCATCTACAGATCACCCAAGCAAAGGGATCATTACAGTCATTCAAAAAAGCTGTCATTCTTGTGGTCGCTGTGGAGAAACTGAAAAGGGGAAAAGAAACCTTTTTTGGGGATGCAGATTTATTAGGCCTTCTGGATAGCATTTTTGTGGAAGAGGAAATTGCTTTCAGCCGAGCCAAAGAAACACACGCCTCCGCTACCACATACCGATACCAGAGGGCCACCAATTGCAGAATTAAGGATGCTTCAAACAAATGCTTTGTCCTGCAGCGGTTCCATGGAAATGCCCAACTGGTGGCTTTGCAGTTACAAGGGGCTAACATTCAAAGAGAAGAGAAGGTAAGCATGGCTTTTTATGCCACACAGCCGCTTCAGGGTGGAAGCAAAAGGCCCGTTGCATTGGGACTCGTTGGAAAGAATCTTTATCTGTCTTGCATAGCAGCAGAAAATGACCAAGGCTCACCACAGCTTTATCTAGAGGAGATAAGCAACATCAAAGATGTGAAGGGCGAGGACTTGAACCGTTTCATCTTCATGAAGTCTCAGAATGGGCTCAGCGAAAGCACCACGCACAGCTTCGAATCGGCCACATTTCCGGGCTGGTACATCAGCACTTCTCAGAAGGAAAATGAGCTGGTCCAAATGGTGCATCAGAAGAACCAGGCAGCCATCAAAGATTTTAATATTTTCCCAACTGTCTGA	Refseq >NM_001085605|Xenopus laevis interleukin 1, beta (il1b), mRNA ATTAGCATTAGAAAGAAGCCAGCACACCACCTGCCCTTGGGACACCCATTAAAGAGCTAAAAAAATGGCATTGGTTCCTGACTTGAGTTCCATTCCCATGGAGGGCTACAGCGGCGACGATGAAATGTTTTACAGTGATAGCCCATCGGGAATGAAGGACGACATGGGAGATGCTGCTCAGTGGCAGTCAAGCACCAGCCATTGCTCCCTGGATATTCATGTGCAGATAACCCATGGAAAAGGATCCTTACACTCCTTCAGAAAAGCTGTCGTCCTTGTGGTTGCCGTGGAGAAACTGAAAAGGGGAAAAGAACGATTTTTCGGGGATGAGGATTTATTAGGCCTTCTGGATAGCATTTTTGTGGAAGAGGAAATTGGTTTCAGCCAAGCCAAAGAAACTTACGCCTCCGCTTCCACATACCGCTATCAGAGGGCCACCACTTGCAGGATTAAGGATACTTCAAACAAATGCTTTGTCATGCAGAAGTTCCATGAGAATGCCCAGCTGGTGGCTTTGCAGTTACAAGGGGCTAACATTCAAAGAGAGGAGAAGGTAAGCATGGCTTTTTATGCTACACAGCCGCATCAGGGTGGAAGCAAAAGGCCCGTTGCTTTGGGACTCGCTGGAAAGAATCTGTATCTGTCTTGCAGAGCAACAGAAGATGGCCAAGACTCTCCAAAGCTTTATCTGGAGGAAATAAGCAACATCAAAGACGTGAAGGGTGAGGACTTAAACCGTTTCATCTTCATGAAGTCTCAGGATGGCCTCAATGAAACCTCCACGAACAGCTTTGAATCGGTTGCATTTCCAGGCTGGTACATCAGCACTTCCCAAAGGGAAAATGAGCTGGTGCAGATGGTGCATCAGAAGAACCAGGAAGCCATCAAAGATTTTAATCTTTTCTCAGTTATCTGATTGTCTGTGTACAATCCAACCAACTGCATGTATGTACTAAGTACAAAGCAGACCAAGGGGTGCTGGGAGATATCTGCCTTCCACTTTATATTGGTATTTGAATTCTAATTCCTACTGAGGCAGGCTCCTAAAGCATAAAATAGAGGGAAATGGTTCAGAAATCTCATCGCAGCATTTATTTAATCTTTGACTTTTATAAAGTCAGAGTTTTTCTGTCTGAGAATATACAAGTAACCCCATGAAGGGTTTTAACACTTTTATTGTTTATTGATATGACACCCAACTATTCCAATCAGGATACTGGGATACTGCTGACATAATGAGCAAATATGTATATTTTTATTTAATATTTTTATTAGTGAACTGTTATTTATTCTATTTATATATTATATATTTATTATTATATGAGTGTGAAATAACAATTGATTTTCTATACACAGTAGTATTTTGATTTGTGTTTCCCTCTGCGGAATGTGATGTATTGGTAATCTGAATAAAATAATTCTGTTTCTAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002932618|PREDICTED: interleukin-1 beta-like [Xenopus (Silurana) tropicalis] MALVPDLSSIPMESCSGDDEMFYSDSPPGMKDSMKDDSQWHSHPGHCSQYNLDIHLQITQAKGSLQSFKKAVILVVAVEKLKRGKETFFGDADLLGLLDSIFVEEEIAFSRAKETHASATTYRYQRATNCRIKDASNKCFVLQRFHGNAQLVALQLQGANIQREEKVSMAFYATQPLQGGSKRPVALGLVGKNLYLSCIAAENDQGSPQLYLEEISNIKDVKGEDLNRFIFMKSQNGLSESTTHSFESATFPGWYISTSQKENELVQMVHQKNQAAIKDFNIFPTV	Refseq >NP_001079074|interleukin 1, beta [Xenopus laevis] MALVPDLSSIPMEGYSGDDEMFYSDSPSGMKDDMGDAAQWQSSTSHCSLDIHVQITHGKGSLHSFRKAVVLVVAVEKLKRGKERFFGDEDLLGLLDSIFVEEEIGFSQAKETYASASTYRYQRATTCRIKDTSNKCFVMQKFHENAQLVALQLQGANIQREEKVSMAFYATQPHQGGSKRPVALGLAGKNLYLSCRATEDGQDSPKLYLEEISNIKDVKGEDLNRFIFMKSQDGLNETSTNSFESVAFPGWYISTSQRENELVQMVHQKNQEAIKDFNLFSVI

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.415
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	IL1B	OMIM:137215
mouse		MGI	Il1b	All(6) Targeted, knock Out(3) Targeted, other(1)
zebrafish		ZFIN	il1b

Publications
First:		Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. [Proc Natl Acad Sci U S A 1984]
Most recent:		Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy. [J Biol Chem 2006]
		View All Papers

Functional Ontologies
GO: Molecular:		interleukin-1 receptor binding
Biological:		immune response inflammatory response
Cellular Component:		extracellular region
EC:
KOG:

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.1049.1.S1_at	Xl.415.1.S1_at
Affymetrix 2.0			Xl2.415.1.S1_at

Symbol legend[+]

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