Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (38) GO Terms (21) Nucleotides (164) Proteins (45) Interactants (823) Wiki
Gene Symbol:

Gene Name:
transducin like enhancer of split 4

XGrg-4 , XTCF-4 , groucho-related gene 4 , Xgrg4 , grg4 , esg4 , Xtle4 , gro , Grg-4 , X-groucho ( Add synonyms , Nomenclature history )

Gene Function:
transcriptional regulator

Protein Function :
Transcriptional corepressor. Functions with ripply2.2/bowline to down regulate transcription of tbx6-dependent gene expression. Represses transcription of siamois and nodal3.

Loading ...


External Links:
Xenbase Gene ID XB-GENE-481766 XB-GENE-17334468 XB-GENE-481770
Gene Symbol tle4 tle4.L tle4.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100101787
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tle4 tle4.L tle4.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC, AGR, Monarch, OMIM, GeneCards TLE4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Tle4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Tle4 Ensembl
fruit fly
First Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri., J Biol Chem 1993  
Most Recent Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation., Development 2019                                              
All View All Papers 9 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 16 terms 0 term 8 terms
KEGG Pathways
KOG [B] Transducin-like enhancer of split protein (contains WD40 repeats)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tle4
Antibodies Tle1 Ab1 Tle1 Ab1 Tle1 Ab1
Morpholinos tle4 MO1 tle4 MO1
ORFs tle4.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info