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Summary Expression Gene Literature (104) GO Terms (50) Nucleotides (137) Proteins (31) Interactants (781) Wiki
XB-GENEPAGE-481819
Gene Symbol:
lrp6

Gene Name:
LDL receptor related protein 6

Synonyms:
Xlrp6 , adcad2 , lrp6-a , lrp6-b ( Add synonyms , Nomenclature history )

Gene Function:
signal transduction

Protein Function :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.


InterPro :
LDLR classB rpt , LDL receptor-like sf , LDLR class-A CS , EGF-like dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
tooth agenesis [+]

OMIM:
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2 [+]

External Links:
 
Xenbase Gene ID XB-GENE-481820 XB-GENE-6252411 XB-GENE-865490
Gene Symbol lrp6 lrp6.L lrp6.S
Chromosome Chr3 Scaffold31 Scaffold16589
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100489328
373826
378494
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine lrp6 lrp6.L lrp6.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LRP6 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lrp6 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lrp6 Ensembl
zebrafish
lrp6 Ensembl
chicken
GEISHA LRP6 Ensembl
fruit fly
worm
Publications
First LDL-receptor-related proteins in Wnt signal transduction., Nature 2000  
Most Recent Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis., MicroPubl Biol 2021    
All View All Papers 17 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 9 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 50 terms 0 term 8 terms
PANTHER lrp6
KEGG Pathways K03068 K03068
KOG [T] Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lrp6
Antibodies Lrp6 Ab1 , Lrp6 Ab2 Lrp6 Ab1 , Lrp6 Ab2 Lrp6 Ab1 , Lrp6 Ab2
Morpholinos (on-target & off-target) lrp6 MO2 , lrp6 MO1 lrp6 MO1 lrp6 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info