F-box-like protein which acts as an integral component of the N-CoR transcriptional corepressor complex. Probably regulates transcription activation mediated by nuclear receptors. May mediate the recru...[+]

F-box-like protein which acts as an integral component of the N-CoR transcriptional corepressor complex. Probably regulates transcription activation mediated by nuclear receptors. May mediate the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of the N-CoR complex, thereby allowing cofactor exchange and transcription activation. [-]

             Pierpont syndrome

          INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 41; MRD41

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD