Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (38) GO Terms (23) Nucleotides (62) Proteins (33) Interactants (879) Wiki
XB-GENEPAGE-482218
Gene Symbol:
nkx2-2

Gene Name:
NK2 homeobox 2

Synonyms:
XeNK-2 , nkx2.2 , Xnkx2.2 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Defines dorsal-ventral domains in developing brain. May play a role in defining positional information along the anterior-posterior (a/p) axis and the dorsal-ventral (d/v) axis of the developing nervou...[+]


InterPro :
Transketolase-like Pyr-bd , DH E1 , 2-oxogl dehyd N , 2oxoglutarate DH E1 [+]

Interactants:
Loading ...

Diseases: 


External Links:
1/3
 
Xenbase Gene ID XB-GENE-482219 XB-GENE-17336182 XB-GENE-864842
Gene Symbol nkx2-2 nkx2-2.L nkx2-2.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038077
108716603
373624
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein TrEMBL NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nkx2-2 nkx2-2.L nkx2-2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NKX2-2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nkx2-2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nkx2-2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR nkx2.2a nkx2.2b ZFIN Ensembl
chicken
GEISHA NKX2-2 Ensembl
fruit fly
worm
Publications
First A Xenopus homebox gene defines dorsal-ventral domains in the developing brain., Development 1993                
Most Recent Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation., Front Physiol 2019                
All View All Papers 7 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 5 terms 6 terms
PANTHER nkx2-2
KEGG Pathways K08029 K08029 K08029
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nkx2-2
Antibodies Nkx2-2 Ab1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info