Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (6) GO Terms (13) Nucleotides (102) Proteins (29) Interactants (161) Wiki
XB-GENEPAGE-482399
Gene Symbol:
timp3

Gene Name:
TIMP metallopeptidase inhibitor 3

Synonyms:
timp3-A , TIMP-3 ( Add synonyms , Nomenclature history )

Gene Function:
metalloproteinase inhibitor

Protein Function :
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling s...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
Sorsby's fundus dystrophy

OMIM:
SORSBY FUNDUS DYSTROPHY; SFD

External Links:
 
Xenbase Gene ID XB-GENE-482400 XB-GENE-864869 XB-GENE-17337079
Gene Symbol timp3 timp3.L timp3.S
Chromosome Chr03 Scaffold31 chr3S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100489929
373596
108712552
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot Swiss-Prot NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine timp3 timp3.L timp3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TIMP3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Timp3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Timp3 Ensembl
zebrafish
chicken
GEISHA TIMP3 Ensembl
fruit fly
worm
Publications
First Cloning and developmental regulation of tissue inhibitor of metalloproteinases-3 (TIMP3) in Xenopus laevis early embryos., Gene 1998        
Most Recent Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis., Dev Genes Evol 2019          
All View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 3 terms 2 terms
PANTHER timp3
KEGG Pathways K16866 K16866 K16866
KOG [R] Metalloproteinase inhibitor TIMP and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks timp3
ORFs timp3.L ORF1
Clones Horizon Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556