Gene Symbol: hoxb3 Gene Name: homeobox B3 Synonyms: hox2.7, hoxb-3 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: egr2(11) , hoxa3(9) , hoxb1(9) , hoxb4(7) , mafb(7) , en2(4) , hoxb9(4) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001015971|Xenopus (Silurana) tropicalis homeobox B3 (hoxb3), mRNA TCCTTTGTGATCCTTTAGGTCGCTTCCCCGAAGATATTCCGTGCCAGGTGACTGTGGGGTGCCAATGTTATTCTGTAAGGGTGGGGACACCCTCCGAGTCGGTGACAGCTGTTTTTGGGGATCCCGGAGATGCAGAAAGCATCCTACTATGACAACCCCACTCTGTTCGGAGGTTACCCCTACCAGGCAGGGAGTCTGGGCTATGAAGGCCCCCAGCAGTCCTTCCCCACTTCTTCCCATATGGACAATGAATTCCAGCGCTCCTCCTGCTCCCTGCAGTCTCTGGGGCACAGCGGCCCTCTGGTCAAAGCTAAGAACCTAAATGGGAGCTGTATGCGCCCCAACCTGTCCTCTGAGCAGTCCCAGCCCCTGTCTCCAACGGCCAACCCCAGTAGCAACACCAACAGCAGCAGCTCCCAGGCTTCCCTCAGCAAGCCCTCTCCAGCCAAAAGCCAGGCCAGCGGCAGCCCAGCCAGCAAGCAGATCTTCCCTTGGATGAAAGAGTCCAGACAGAACTCCAAACAGAAATCCAGCCCCCCCGCCCCAGCGGCAGAAAGCTGCGGCGGTGACAGGAGCCCCCCGGGTTCGTCTGCGTCCAAGAGAGCGCGTACGGCCTACACCAGCGCCCAACTGGTCGAACTGGAGAAGGAGTTTCACTTCAACCGCTACCTGTGCCGGCCCCGCCGGGTGGAAATGGCCAATCTGCTCAACCTGAGCGAGAGGCAAATCAAGATCTGGTTCCAGAACCGGAGGATGAAGTATAAGAAAGATCAAAAGGTAAAAGGCATGTCTTCTTCATCAGGAGGAGCTTCACCGACTAGCACACCGCCCCTGAGCATGCAGTCGTCTGCAGGGTTCCTGGGATCCATGCACTCTATGACTGCGAATTATGAGGCGCCCTCCCCGCCCCCGTTTAATAAGTCCCACCAGAATGCCTACTATCAGAACCCTGGCAAAGGTTGCCCCTCTCAGCAGAAGTATGGGAACACTGCTGCAGAGTACGACCACCATGGCTTACAAGGGAATGGGGGCGCCTATGTGTCCCCCAATATGCAAGGAAGTCCGGTGTACGTAGGGGGTAACTATGTGGATTCTGTGCCAGCACAAGGCCCGCCTCTTTATGGTCTCAACCACCTTGCACACCAGCCCACCAATATGGACTACAATGGGGCTCCTCCCATGCCAGCCAGCCAGCACCATGCACCTTGTGACCCCCACCCAACCTACACAGAGCTCTCAGCCCACCACCAGGGCAGGATCCAGGAAGCCCCCAAATTGACCCATTTGTGATTAAGAAGTAATACCCATTTCTGACTACAGAGGGCGCTCAGCCCGACCATCACCTCGGGGGAACAATAAAACATTTCCACTTGATCTATTTTTCTTAAACATTTTTTTAAACCTATAGAGATGTTACAGAATCTTTTTTTTTTTTTTTGTTGCACTGTAGTATCGAAACATGATTCAGTCAACACAGGGGGAAAGACCTGTTATTATAGGGCGTAATATAGCTGCAATTATGGACCTTTTTATGATCTCAAAAATATCACCAGAGTTGAGAGTCCATGTCAGTGTATACTGTGTAATTATAGATAATGTGTCAGACTAAAAACGCCCACTGGGGTCACCTGATGGGTTTCTAGCTTGATCCAGGGGCCAGCCTTTGTTTTTTTTTTTTTAATCGTGGTTCCAATATCTTTAGTTTGTAGAAGCAAGAAAAATACAGGTAATAACGATTTTATTTCATTTGCGATCTGGTGTAACTGGCTTTCCCATGAGTTTTTATTTTTTTAGTCGTAGCATCCTAGGCCTTAAGATCAAAGAACGAAGGAAGATGTAACTACCTAGATAAATGCCACTGTGCGACTTTGCTGTGAGATCAGGTATAGGATTCCTAAAAAAAAAAAGTACAATTCTCACAGCCCTTAACAGGATGGACTTGAATTAAAAAAAAAAAAAAAAAA	NCBI Nucleotide >M91588|Xenopus laevis homeobox protein (Hox 2.7) mRNA, partial cds TCGAAGAGAGCGCGCACCGCTTACACGAGCGCACAACTGGTGGAACTGGAGAAGGAGTTTCACTTTAATCGCTACCTGTGCCGCCCCAGGAGGGTGGAGATGGCCAACCTGCTCAACCTGAGCGAGAGGCAAATCAAGATCTGGTTCCAGAACCGAAGGATGAAGTATAAGAAAGATCAA
Protein		Refseq >NP_001015971|homeobox B3 [Xenopus (Silurana) tropicalis] MQKASYYDNPTLFGGYPYQAGSLGYEGPQQSFPTSSHMDNEFQRSSCSLQSLGHSGPLVKAKNLNGSCMRPNLSSEQSQPLSPTANPSSNTNSSSSQASLSKPSPAKSQASGSPASKQIFPWMKESRQNSKQKSSPPAPAAESCGGDRSPPGSSASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKVKGMSSSSGGASPTSTPPLSMQSSAGFLGSMHSMTANYEAPSPPPFNKSHQNAYYQNPGKGCPSQQKYGNTAAEYDHHGLQGNGGAYVSPNMQGSPVYVGGNYVDSVPAQGPPLYGLNHLAHQPTNMDYNGAPPMPASQHHAPCDPHPTYTELSAHHQGRIQEAPKLTHL	NCBI Protein >AAA49751|homeobox protein [Xenopus laevis] SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQ UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.27369	[+] Xl.51509
Unigene EST Profile		EST Profile
GEO data			GEO
Images		14 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tneu134e01

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	HOXB3
mouse		MGI	Hoxb3	All(3) Targeted, knock Out(1)
zebrafish		ZFIN	hoxb3a	10 Lines(s)

Publications
First:		The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. [EMBO J 1994]
Most recent:		Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. [Dev Cell 2011]
		View All Papers 8 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[R] Transcription factor zerknullt and related HOX domain proteins

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		Str.27369.1.S1_at [+] Str.27369.1.S2_at	Xl.20001.1.S1_at
Affymetrix 2.0			Xl2.20001.1.S1_at [+] Xl2.51509.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images