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Summary Expression Gene Literature (475) GO Terms (19) Nucleotides (53) Proteins (29) Interactants (1445) Wiki
XB-GENEPAGE-483208
Gene Symbol:
nodal

Gene Name:
nodal growth differentiation factor

Synonyms:
Xnr-4 , Xnr4 , nr4 , nodal4 , Nodal homolog 4 ( Add synonyms , Nomenclature history )

Gene Function:
transforming growth factor beta and bone morphogenetic protein related protein

Protein Function :
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development.


InterPro :
TGF-b propeptide , TGF-beta-rel , Cystine-knot cytokine , TGF-b C [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
situs inversus

OMIM:
HETEROTAXY, VISCERAL, 5, AUTOSOMAL; HTX5

External Links:
 
Xenbase Gene ID XB-GENE-483209 XB-GENE-864954 XB-GENE-17339551
Gene Symbol nodal nodal.L nodal.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100497218
398068
108697489
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nodal nodal.L nodal.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tgas097d22      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NODAL OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nodal MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nodal Ensembl
zebrafish
ZFIN, AGR ndr2 ZFIN Ensembl
chicken
GEISHA NODAL Ensembl
fruit fly
worm
Publications
First Effects of ionic concentration on permeability properties of nodal membrane in myelinated nerve fibres of Xenopus laevis. Potential clamp experiments., Acta Physiol Scand 1973  
Most Recent Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway., Development 2020  
All View All Papers 91 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 11 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 3 terms 3 terms
PANTHER nodal
KEGG Pathways K04666 K04666 K04666
KOG [T] Transforming growth factor beta, bone morphogenetic protein and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nodal
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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