On Wednesday Feb. 22 to Thursday Feb. 23, 2017 Xenbase will be in a maintenance phase. The site will be available but some functions may be disabled.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (77) GO Terms (21) Nucleotides (62) Proteins (23) Interactants (605) Wiki
XB-GENEPAGE- 483692

Gene Symbol: pax8

Gene Name: paired box 8

Synonyms: XPax8 , XPax-8 , pax-8
Add Xenopus synonyms , Nomenclature history


Gene Function: paired box transcription factor

Protein Function:
Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 to establish the pronephric primordium in late gastrulae/early neurulae.

Interactants: pax2 (42) , lhx1 (29) , wt1 (18) , tbx2 (17) , myod1 (15) , sox2 (13) , wnt4 (12) View All

OMIM Disease Associations: HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 2; CHNG2
1/8
 
Xenbase Gene ID XB-GENE-483693 XB-GENE-865008 XB-GENE-17334490
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol pax8 pax8.L pax8.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0 GBrowse 9.1
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.51436 Xl.2754
RNA-seq profile: Owens, Blitz et al. 2016 pax8
Images 167 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine pax8 pax8.L pax8.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PAX8 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Pax8 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN pax8 ZFIN Ensembl
chicken
fruit fly
worm
WORMBASE
Publications
First: Molecular regulation of pronephric development. [Curr Top Dev Biol 1999]
Most recent: Pax2/Pax8-defined subdomains and the occurrence of apoptosis in the posterior placodal area of mice. [Brain Struct Funct 2017]
View All Papers 32 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 19 terms 15 terms 0 term
EC
PANTHER pax8
KEGG K09293 K09293
KOG [K] Transcription factor PAX2/5/8, contains PAX domain
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s) EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Antibody Pax8 Ab1 Pax8 Ab1
Morpholino pax8 MO1 , pax8 MO2 , pax8 MO3 pax8 MO1 , pax8 MO2 , pax8 MO3 pax8 MO1 , pax8 MO2 , pax8 MO3
Affymetrix 1.0 Str.51436.2.S1_s_at [+] Xl.2754.1.S1_at
Affymetrix 2.0 Xl2.2754.1.S1_at [+]

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.2.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556