Gene Symbol: grem1 Gene Name: gremlin 1, DAN family BMP antagonist Synonyms: cysteine knot superfamily 1, Cktsf1b1, gremlin Add Xenopus synonyms Gene Function: BMP antagonist Interactants: cer1(9) , nbl1(7) , nog(6) , shh(5) , bmp4(4) , chrd(3) , fgf8(3) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001100231|Xenopus (Silurana) tropicalis gremlin 1 (grem1), mRNA AAGGATTTCCCCCCGTGTAGCCTCACATGGACTGTGCCCCTAGCCCTGCTCTGCTGTGAGCCAGCGGCCCTACTTACAGGATGAACTGTCTCGTTTATGCTCTAGGATCCCTTTTCCTTCTGAGTGGGCTCCTCCTCCCCAGCTCTGAAGGGAAGAAGAAGGTTAGTGGATCACAGGGAGCCATTCCTCCCCCTGACAAAGGGCAGCCCAATGACTCTGAACAAGGTCAAACACAGCCAGGAGGCCGGGGCCGAGTTAAAGGGAAGGGACAAGCACTAGCAGCTGAAGAAGTGCTCGAGTCCAGTCAAGAAGCTCTACATATCACTGAACGCAAGTATCTAAAGAGGGACTGGTGTAAGACTCAGCCCTTAAAGCAAACTATTCATGAGGATGGGTGTAACAGTCGTACCATCATCAACCGCTTTTGCTATGGGCAATGCAACTCCTTCTATATCCCCCGTCACATACGCAGGGAGGAGGGCTCCTTTCAATCCTGCTCCTTCTGCAAACCTAAAAAATTTACCACAATGGTGGTCACCCTGAACTGTCCAGAGCTTCAGCCTCCCACAAAGAAGAAGAGAATCACACGTGTCAAGCAATGTCGCTGCATCTCCATAGACCTGGACTAATGGTCCCCGGGCCTGTGAGCACTAGAATAATGGGAGCTTCGCACTTCGTATTCATACCATTTCTGTCTGTGCCAAGACCAGCAAACCGTGGCCCTCACAGACGTTCAGTTGTGTCCGAGCCACTTTATGCTTTCAGAGAAAAACAGCTCATGCTACTACACCATAGGCAGGAATCCGAACAAGCAATAAATATATAGATTTAGTCCTTCTGTTGAACTATCCTAATCAGTGTTGGGTTCCTTATATTTTCTAGGGAATATGGAGGCCTGCAAAGCGAGTATCCATGTATACATTGTGTACATATATATTATTTATTCTCACGTGTGTGTTTCTGTGCACATGAAAGAGCATGAGGGAAGGAAGCCAAGGCTGTTAATATCTGGACTTGCTGTTAAGCACTAGGAGTTAATGAATTGTGCATGTTACTGGCATGTAGCAGTGAATGGCCACTGCAGGAGACCCATTATTAAGGCAACATGTAACTTTCTGACTTTGCAAGGTTCACTGTGGGTAAACATGCCTTAAGAACAATACATTCTCTTTTCCATGGGTTAATCTGCCAGGAACCAGAAAAATACGGCAGTGTATAAATTCAGTTCGAAGACAGAGGATGCCATGTTAGGCATGTACAGTCTGATCATCTAAATATATCTTCTCAAACTGTAAAAAAAAAAAAAAAA	Refseq >NM_001090277|Xenopus laevis gremlin 1 (grem1), mRNA CCCGTGTAGCAGCCTCACATGGACTAGTCTTGATCTGCTGTGAGCCAGCGGCCCCTTCCCACAGGATGAACTGTCTCGTTTATGCTCTAGGATCCCTTTTCCTTCTGAGTGGGCTCCTCCTCCCCAGCTCCGAAGGGAAGAAGAAGGTTAGTGGATCACAGGGAGCCATTCCTCCCCCTGACAAAGGGCAGCCCAATGACTCTGAGCAAGGTCAAGCTCAGCCAGGAGACCGGGTCAGAGGGAAGGGGAAGGGACAAGCACTAGCGGCTGAAGAAGTGCTGGAGTCCAGTCAAGAAGCTCTACACGTCACTGAACGCAAGTATCTAAAGAGGGACTGGTGTAAGACTCAGCCCTTAAAGCAAACAATTCACGAGGACGGGTGCAACAGTCGTACCATCATCAACCGCTTCTGCTATGGGCAATGCAACTCCTTCTACATCCCCCGTCACATACGCAGGGAGGAGGGCTCATTTCAATCCTGCTCCTTCTGCAAGCCTAAAAAATTCACCACAATGGTGGTCACCCTGAACTGCCCAGAGCTACAACCTCCCACAAAGAAGAAGAGAATTACACGTGTCAAGCAGTGTCGCTGCATCTCCATAGACCTGGACTAATGTGCCGCTGGGCCTGTGAATACTAGAATAATGTACTGGGAGCTTCACTCTTCATATCCATACCATTACTGTCTGTGCCAAGACCATCAAACCACAATCCTCACAGGCATTCTGTTGTGTCCGAGCTACTTTATGCTTTTCATGCTAATACACCATCAGCAGGAATCCAAACAAGCAATAAATATCTAGATTTCCTCCTTCTGCTGAACTGTCCCGAACAGCGTTGGGTTCTTTATCCTTTTTTTTAGGGAATGTGGAGGCCTGCAAAGACGGCATCCATGTATACATTGTGTACATATATATTATTTATTCTCACGTGTGTTTTTGTGCACATAAAAGAGCATGAGAAAAGGCGCTGAGACTGATGAGAGTTAATGAATTGTGCATGTTACTGGCATGTAGCTGTGAGTCGCCACTACAGGAGACCCAATATTAAGGCAATCTATGACTTTCTGTAAGGTTCTCTGTGGGTAAACATGCATTATCCACAATACATTTTCTTATATGTGGGTTAATCTGCCACAAACCTGGCAAATATGGCAGTTTGAGGACAGAAAATGCCATGTGAAGCATGTACAGTCTAATCATCGCAATATATTTTTTAAAACCATTGTGGCTGATTTGGGGGGTAAAGAGCAACACAATGCAGGGAAGTTCCCAGGAGTTGGGGAGACTAATGGCATATTTCTCATGTATTGAAGACTGCCGGGAGAGAGAGAAGCAAACTGGTGCCAAATGGCAGTGGAAAAAGAACGAGGAGGATGAGATATTGAGGCATTTTACTAGGGACTAGATTACTGCAATTTAAAGTTGCTCTGACTCCTCTTATTCACATTTGGGACTGTAGCAACAACAACTCTGTGTCATTTTATTGAGGTCAGGGGTGGGAAACAAATCACTGCATGGCTGGTTATGTCCAGACAGAACCACCCCAAACCCCTCTCGCTTCCCAGAAAGTCCCACAACTGCAATCTGAGACTGTCCCAGCAAAACAGGACAATCTAGGGAAAATGCCATTGCAATTGTAGTGTTGCACGATAAACTGTTCCCTAAAAAAAAAATTATTTGTATTAAACAAATTAGCGCAGAAAGTTTGCCAATAATATGAGCTTCATGATAAATAAAGAAACAGTACAAGATGGAAATATTAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001093701|gremlin 1 precursor [Xenopus (Silurana) tropicalis] MNCLVYALGSLFLLSGLLLPSSEGKKKVSGSQGAIPPPDKGQPNDSEQGQTQPGGRGRVKGKGQALAAEEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEDGCNSRTIINRFCYGQCNSFYIPRHIRREEGSFQSCSFCKPKKFTTMVVTLNCPELQPPTKKKRITRVKQCRCISIDLD	Refseq >NP_001083746|gremlin-1 precursor [Xenopus laevis] MNCLVYALGSLFLLSGLLLPSSEGKKKVSGSQGAIPPPDKGQPNDSEQGQAQPGDRVRGKGKGQALAAEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEDGCNSRTIINRFCYGQCNSFYIPRHIRREEGSFQSCSFCKPKKFTTMVVTLNCPELQPPTKKKRITRVKQCRCISIDLD UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.31102	Xl.318
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		6 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	GREM1
mouse		MGI	Grem1	All(9) Targeted, other(5) Radiation Induced(1) Spontaneous(1) Targeted, knock Out(1)
zebrafish		ZFIN ZFIN	grem1a grem1b

Publications
First:		The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. [Mol Cell 1998]
Most recent:		The neural crest is a powerful regulator of pre-otic brain development. [Dev Biol 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:
Cellular Component:
EC:
KOG:

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.31102.1.A1_at	Xl.318.1.S1_at
Affymetrix 2.0			Xl2.318.1.S1_at

Symbol legend[+]

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