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Summary Expression Gene Literature (214) GO Terms (19) Nucleotides (67) Proteins (34) Interactants (407) Wiki
XB-GENEPAGE-484542
Gene Symbol:
grem1

Gene Name:
gremlin 1, DAN family BMP antagonist

Synonyms:
cysteine knot superfamily 1 , Cktsf1b1 , gremlin ( Add synonyms , Nomenclature history )

Gene Function:
BMP antagonist

Protein Function :
Cytokine that has an axial patterning activity. Acts like BMP antagonist in embryonic explants. Blocks the BMP2 activity.


InterPro :
CDCA2 , PP1-bd , Glyco hydro 38 N sf , Glyco hydro 38 cen sf [+]

Interactants:
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Diseases: 


External Links:
1/2
 
Xenbase Gene ID XB-GENE-484543 XB-GENE-865098 XB-GENE-17332907
Gene Symbol grem1 grem1.L grem1.S
Chromosome Chr8 chr8L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100101711
399094
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine grem1 grem1.L grem1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GREM1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Grem1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Grem1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR grem1a grem1b ZFIN Ensembl
chicken
GEISHA GREM1 Ensembl
fruit fly
worm
Publications
First The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities., Mol Cell 1998                    
Most Recent Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction., Dev Biol 2020          
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 11 terms 0 term
PANTHER grem1
KEGG Pathways K23318 K23318
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks grem1
Morpholinos grem1 MO1 , grem1 MO2 grem1 MO1 , grem1 MO2 grem1 MO1 , grem1 MO2
ORFs grem1 ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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