Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (112) GO Terms (12) Nucleotides (96) Proteins (36) Interactants (638) Wiki
XB-GENEPAGE-484854
Gene Symbol: gli3

Gene Name: GLI family zinc finger 3

Synonyms: XGli-3 , Xgli3 ( Add synonyms , Nomenclature history )

Gene Function: zinc finger, C2H2 type; hedgehog signaling

Protein Function :
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGG...[+]

Interactants: Loading ...
Disease Ontology: polydactyly [+]

OMIM Diseases: ACROCALLOSAL SYNDROME; ACLS [+]

1/8
 
Xenbase Gene ID XB-GENE-484855 XB-GENE-865509 XB-GENE-17346222
Gene Symbol gli3 gli3.L gli3.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq TrEMBL Swiss-Prot NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine gli3 gli3.L gli3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards GLI3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Gli3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR gli3 ZFIN Ensembl
chicken
GEISHA GLI3 Ensembl
fruit fly
worm
WORMBASE
Publications
First GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity., Mol Cell Biol 1990  
Most Recent Gli2 is required for the induction and migration of Xenopus laevis neural crest., Mech Dev 2018                        
All View All Papers 8 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 7 terms 11 terms 6 terms
PANTHER gli3
KEGG Pathways K06230 K06230
KOG [R] FOG: Zn-finger
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Morpholino gli3 MO1 , gli3 MO2 , gli3 MO3 gli3 MO1 , gli3 MO2 , gli3 MO3 gli3 MO1 , gli3 MO2 , gli3 MO3
Affymetrix 1.0 StrJgi.1039.1.S1_s_at [+] Xl.1041.1.S1_at
Affymetrix 2.0 Xl2.1041.1.S1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.0


Major funding for Xenbase is provided by grant P41 HD064556