mapk12 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (3)

Nucleotides (119)

Interactants (14)

XB-GENEPAGE-485781

Gene Symbol: mapk12 Gene Name: mitogen-activated protein kinase 12 Synonyms: Xp38gamma, SAPK3 protein kinase, sapk3 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: map2k6(3) , mapk1(3) , mapk14(3) , atf2(2) , elk1(2) , mapk11(2) , mapk8(2) View All

XB-GENE-485782

XB-GENE-485786

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001017080\|Xenopus (Silurana) tropicalis mitogen-activated protein kinase 12 (mapk12), mRNA CCGGGTCACGTGACGGCACAAAGCTCCGGGCTCTATATGGGAAATACTTCCCGTCACTGGGCAGCTACTGTGCAGGCTGAGGGTGCGGGAAATACGCACAGTGGACAAAAGGAAAACGAAAGTGTAAGGCGAGAGCTGACCGAAGAGCGAAGACGCAGAAAGAGGGGCTGGTCGGAAGAGACTGTTCTACGTAAAGAAGGCAGCCGGTCCCTCATGGTGAATAAGAGCAGGACAAGTCAGTACTGCTCACCGTGACATTACTGTACCTCTCAGGAGAGCCGCCCAGTATCAGCAGTCAGGTGACTCTGCCTGGGACCCACATTCACATAGTACTAGTGCAACAGGAGCCTGCTGGCAACTAGTAGCCATGTCCACCTCCCCGTTGCCCAAGAAGGGATACTATAGGCAGGACGTCAATAAGACCGTCTGGGAGGTGAAGGAGAGGTACAGAGACCTGGTGGCTGTGGGATCAGGAGCCTATGGCACTGTTTGCTCATCTCTAGACACTAGAACTGGAACAAAAGTAGCTATCAAGAAACTGTACCGTCCTTTTCAATCTGAACTCTTTGCAAAGCGAGCATATAGAGAGCTGAGGCTTTTGAAGCACATGCAGCATGAAAACGTAATTGGTCTATTGGACGTGTTTACTCCAGACTCAACTTTGGAAAATTTCAATGATTTTTATTTGGTGATGCCATTCATGGGTACGGACCTTGGCAAGATAATGAAACATGAAAAGCTATCTGAAGACCGAATCCAGTTCCTGGTTTATCAGATCCTCAGGGGGCTAAAGTACATTCATTCAGCTGGAATCATCCACAGGGATTTAAAGCCTGGAAATCTTGCAGTAAATGAAGACTGTGAGTTAAAGATTCTGGATTTTGGCCTGGCAAGGCACACAGATAGTGAAATGACTGGTTACGTGGTGACCAGATGGTACAGAGCCCCAGAGGTTATACTCAATTGGATGCACTACACTCAGACAGTGGATATCTGGTCTGTTGGATGTATCATGGCAGAGATGTACACTGGGAGGCCACTTTTCAAGGGAAATGACCATCTAGACCAGCTAACAGAAATAATGAAAATTACTGGGACACCAACTCAGGATTTTGTCCAGAAGCTCCAGAGTCCTGATGCTAAAAACTATATCAAGAGCCTTCCTAAAGTGCAGAAGAAAGACTTTGGATCATTGCTAAGATATGCAAACCCTCTTGCTGTAAATATCCTTGAGAAGATGTTGGTACTGGATGCAGAAAAGAGGATAACTGCGACAGAGGCTTTAGCACATCCATACTTTGAACAGTTCCATGATATTGATGATGAGACAGAAGCTGAACCCTATGATGATTCATTCGACAATGTAAATCTTCCTCTGGAGGAGTGGAGGCGTCTCACACACAAGGAGCTTACTAGCTATAAGCCATTGGTGGCTGATTCAAAGGAAACATCGGTATAACATGTCGCAAAACTGCAAATGTGAGCCGTAACTTTTCAAAACTGGACTATAAATTGGATGTAAAGTGTATGGTCTATATCGTAGGAACCATTTGTGTTGCTCCCCCAACAAGGATCTAGTGCCTTTTTGTATATCCTTCGTGTAGGGGTGTTTGATTTGCCAGTATGTTCTCTTACTGCTGCAGATAATGTGCTGTTATTGTGAAGAAATGGTGTTCAAAATGACATGATTTAATTCCATTGTGAAGATTCAGTGTAAGTGTAGAATTTTGCTTTTGCCTTTGTATGAGTGGTCTGACTGTGCTGCCTTTGCCTACCACAATATATATTTCCACAAACCTTAGCACTAGGTAGATGTGAGCTTATTCTGCCTAAAATGCTTATTTTGGTTAGGGTCGTACTCTTTCTATTTCTCTTGCCGATATTGTTCCAGTATGAAGTACAGCTTAAAGCCCCACATTTGGAATAGAAATGTTGCATAAAACCTTAACAGCTAATATTTCACATATGGACACACATATATTGCCATTGTTGTTAGCCACCCTATATTAAGTGGCCATTTCAGATTCACATAATTTGTTTAAATATTTTGGTGCAGTGGTTTATCATCTGCTTCACTTTTACATTAACATAATTCTCTGTTAGAGCTCACATAGCACTAAAGTAAAATAGCCCCTACAAACAATGTATGCAATCAGGAATCACATCAATACAGGTTCTTCCCCTAGACTTGGTTCTTTAAAAAAAAAATTATGATATACCTGTCAGTTGAAATCCCCTTCTCCCATTCTCATTGCATATAAAAAACCCTGCTTTGCACAGACATGCCTCTATTCTTTGCCTCAGCTCCACTCTGGCCCCAGCATTTCTGTCATGTGCAATCTCACTGCTAATGTCTCATTAATATCACTCACTGCAAGTAAAATGTGTTTCCAGGTGCATACCTCTTGACCATGTTCTCTGTGAGAATAGTAGAACAGTTAACAGTGAAATGACAATATCCAGCTATTTATAAACTGTATTTTATAGGAGTTTCAGAGTCAGGCTTGAGAGTAAGGATTTGAAAGCATAAAGGCAAATTAAGATGGGATGTCTCCTAAACTGACTCTGCAAGATCACTGCAAAAAAAAAAAAAAAAAA	Refseq >NM_001089127\|Xenopus laevis mitogen-activated protein kinase 12 (mapk12), mRNA AATACGCAGAGTGGACAAAAGGAGAACGAAAGTGGAAGGCGAGAGCTGACCGAAGACGCACAGACAGGGGCTTGTAGGAATACACTGTACAATACACGGCGTTACGTTGGAGAGGCTGCGTGTCCCTGACGTGAATAAGAGCAGGACAAGTCTGTACTACTCCCCGTGACATTACTGTACCTCTGACGAGAGACGCCCAGTATCCGCCGTCTGGTGACTCTTCCTGGGATCCACACGCACATAGCGCCAGAGCAACAGGAGCCTGCCGGGAACTCGCGGCCATGTCCACCTCCCCGCTGCCCAGGAAGGGATACTATACCCAGGAGGTGAATAAGACTGTGTGGGAGGTGAAGGAGAGGTACAGAGAGCTGCTGGCTGTGGGCTCAGGAGCCTATGGTATTGTTTGCTCATCTCTTGACACTAGGACTGGAACAAAGGTAGCTATCAAGAAACTGTACCGTCCTTTTCAATCGGAACTCTTTGCAAAACGAGCTTATAGAGAACTGAGGCTTTTGAAGCACATGCAGCATGAAAACGTAATTGGATTATTGGATGTTTTTACTCCAGACACAAATTTGGATAAATTCAATGATTTTTATTTGGTGATGCCATTCATGGGTACAGACCTTGGCAAGATAATGAAACATGAAAAGCTATCAGAAGACCGAATCCAGTTTCTGGTTTACCAGATCCTCAGGGGGCTAAAGTACATTCATTCAGCTGGCATAATCCACAGGGATTTAAAACCTGGAAATCTTGCAGTAAATGAAGACTGTGAATTAAAGATTCTGGATTTTGGCCTGGCAAGACACACAGACAGTGAAATGACTGGTTATGTGGTGACCAGATGGTACAGAGCCCCAGAGGTGATACTCAATTGGATGCACTACACTCAGACAGTGGATATCTGGTCGGTTGGCTGTATCATGGCAGAGATGTACACCGGGAGGCCACTGTTCAAGGGAAATGACCATCTGAATCAGCTAACAGAAATCATGAAAATTACTGGGACACCAACTCAGGATTTTGTCCAGAAGCTCCAGAGTACTGATGCTAAAAACTATATCAAGAGTCTCCCTAAAGTGCAGAAGAAAGACTTTGGATCATTGCTAAGATATGCAAACCCTCTTGCTGTAAATATCCTTGAGAAGATGTTGGTGCTGGATGCAGAGAAGAGGATAACTGCCACAGAGGCTTTAGCACATGCTTACTTTGAGCAGTTCCATGATATTGATGACGAGACTGAAGCAGAACCCTATGATGATTCATTTGACAATGTAAATCTTCCCCTGGAGGAATGGAAACGGCTCACACACGAGGAGCTCACTAGCTTTGAGCCATTGGTGGCCGATTCAAAGGAAACTTCGGTATAATGTGTCACAAGGCTGCAAACAAATGTGAGCTGTAACTGTTCAAAACTGGACTTTAACTGGATGTAAACTGTATGGTCTTTATTGTAGGAACCATTTGTGTTGCTCCCCCAACATGGATCTAGTGCCTTTTTGTATATCCTTTGTAGGGGTGTTTGATTTGCCAGTTCGTTATCTTACTGCTGCAAATAATGTGCTATTATTGTGAAGAAATGGTGTACAAAATGAAATGATTCATTCCATTGTGACGATTCAGTGTAAGTGTAGAATTTTGCTTTTGCCTTTGTATGAGTGGTCTGACTGTACTAGCACACTATATATTCCCACAAACCTTAGCACTAGGTAGATGTGAACTTATTCTGCCTAAAATACTAATTTCTGTTAGGGTTGTATTCTTTCTGCTCTGCTGATATGGTTTCAGTATGTAGTGTAGCTTAAATCCCCACATTAGGAATAAAAATGGTACATAAATCATAGAAAGCTAATATTTTTTAAGTCTATGGAATATTGCCATTGCTGCTAACCAGCCTTTAATGTACTATATTAAGTGCCCATTTCAAATTCACATTATTTGTTTAAATATTTTTGTTCCAGTATTTTGTCATCTGCTTCACTCTTACACTACCTGACATAATTCTCTGGACCCATTGGTTCATTTAGCACTACATTAAAATAAAGCATTAAGTCAAAATGTAAATGAATAGGCATTACTGCCCTGTAATACGAAATGGTGCCTATAAACATTGCTTGCCATCAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001017080\|mitogen-activated protein kinase 12 [Xenopus (Silurana) tropicalis] MSTSPLPKKGYYRQDVNKTVWEVKERYRDLVAVGSGAYGTVCSSLDTRTGTKVAIKKLYRPFQSELFAKRAYRELRLLKHMQHENVIGLLDVFTPDSTLENFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQILRGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHTDSEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMYTGRPLFKGNDHLDQLTEIMKITGTPTQDFVQKLQSPDAKNYIKSLPKVQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEALAHPYFEQFHDIDDETEAEPYDDSFDNVNLPLEEWRRLTHKELTSYKPLVADSKETSV	Refseq >NP_001082596\|mitogen-activated protein kinase 12 [Xenopus laevis] MSTSPLPRKGYYTQEVNKTVWEVKERYRELLAVGSGAYGIVCSSLDTRTGTKVAIKKLYRPFQSELFAKRAYRELRLLKHMQHENVIGLLDVFTPDTNLDKFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQILRGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHTDSEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMYTGRPLFKGNDHLNQLTEIMKITGTPTQDFVQKLQSTDAKNYIKSLPKVQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEALAHAYFEQFHDIDDETEAEPYDDSFDNVNLPLEEWKRLTHEELTSFEPLVADSKETSV

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.12075	Xl.54880 [+] Xl.57993
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		15 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	MAPK12
mouse		MGI	Mapk12	All(2) Targeted, knock Out(1) Targeted, other(1)
zebrafish		ZFIN	mapk12a

Publications
First:		Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). [EMBO J 1997]
Most recent:		Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C. [EMBO J 2003]
		View All Papers

Functional Ontologies
GO: Molecular:		ATP binding MAP kinase activity cAMP-dependent protein kinase activity More[+] cAMP-dependent protein kinase regulator activity protein kinase CK2 activity protein kinase CK2 regulator activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:		cAMP-dependent protein kinase complex protein kinase CK2 complex
EC:		now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
KOG:		[T] Mitogen-activated protein kinase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.12075.1.S1_at [+] Str.12075.2.A1_at Str.12075.1.S2_at	Xl.12756.1.S1_at
Affymetrix 2.0			Xl2.12756.1.S1_at [+] Xl2.54880.1.S1_s_at

Symbol legend[+]