pkm Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (20)

Nucleotides (621)

Interactants (28)

XB-GENEPAGE-485872

Gene Symbol: pkm Gene Name: pyruvate kinase, muscle Synonyms: cthbp, pyruvate kinase, pk3 Add Xenopus synonyms Gene Function: Pyruvate kinase Interactants: pklr(18) , npm1(5) , eif3a(2) , myc(2) , vim(2) , ckm(1) , coil(1) View All

XB-GENE-485873

XB-GENE-485877

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001079064\|Xenopus (Silurana) tropicalis pyruvate kinase, muscle (pkm2), transcript variant 3, mRNA GAGGGTTGTAACTGCGGGGGATCACCTTGTTCAGTACAGTTTGCCGGCATCTGTCAGACGGTTGGAGAGCAGTGCGGTTAGCGGAACTGTTTGCTGCTTTACGTAGATTGCACACAGGTCAACATGTCTGAGGCAGGTAGTGCTTTCATTCAGACCCAGCAGCTGCATGCTGCCATGGCAGACACCTTCTTGGAGCACATGTGCCGTCTGGACATAGACTCTGAGCCAATTGTGGCACGTAACACTGGCATTATCTGCACTATTGGCCCAGCCTCCCGTTCTGTGGAAATACTAAAGGAGATGATAAAATCTGGAATGAATATTGCTCGTCTGAACTTTTCCCATGGAACACATGAGTACCATGCTGGCACAATTAAAAATGTACGTGAAGCCACCGAGAGCTTTTCTTCCAATCCCATTCACTACCGGCCTGTGGCAGTGGCCTTGGACACAAAGGGACCAGAAATCCGCACTGGTCTCATCAAAGGAAGTGGTACAGCAGAAGTGGAGCTCAAAAAGGGAGCAACCTTGCGTATCACTCTTGATGATGCCTTCCAGGAAAAGTGTGATGAGAATATACTGTGGGTGGATTACAAAAACCTTACAAAAGTGGTGAAACCTGGCAGCAAGATCTATGTGGATGATGGACTTATTTCCTTGCTTGTTAAAGAGACTGGTGCAGACTTCTGCTTGACTGAGGTTGAGAACGGGGGCATGTTAGGAAGCAAGAAGGGAGTGAACCTCCCTGGGGCAGCTGTGGATTTGCCTGCCGTATCTACAAAAGATATCCAAGATCTGCAGTTTGGTGTGGAGCAAAATGTTGACATGGTTTTTGCTTCTTTTATCCGAAAGGCAGCAGATGTACATGCAGTGAGGAAAGTTCTTGGAGAGAAAGGCAAAAACATCAAGATTATCAGCAAAATTGAAAACCATGAGGGCGTGCGCAGGTTTGATGAGATTCTAGAAGCAAGTGATGGTATAATGGTGGCACGTGGTGACCTTGGTATTGAGATCCCTGCTGAAAAAGTCTTCCTGGCCCAGAAGATGATGATTGGACGATGCAATCGTGCTGGCAAACCTGTGATCTGTGCCACTCAGATGCTGGAAAGCATGATTAAAAAGCCTCGTCCAACACGCGCTGAAGGTAGCGATGTGGCCAATGCTGTACTGGATGGGGCTGACTGTATAATGTTGTCAGGGGAGACTGCAAAGGGAGACTACCCACTGGAGGCTGTCCGCATGCAGCATGCTATTGCTCTGGAGGCCGAGGCTGCTGCATTTCATCGTCAGCTCTTCGAGGAACTTTTCCGTGCCACTGCTAGCTCAAAGGACCCAGCGGAAGCAATGGCTCTAGGCGCAGTGGAGGCATCTTTTAAATGCTTAGCAAGTGCGCTCATAGTGATGACAGAGTCTGGCAGGTCTGCACATTTAGTATCTCGGTACCGCCCACGCGCACCCATCATTGCTGTGACTCGTAATGGGCAGACAGCACGTCAGGCACATCTCTACCGTGGCATTTTTCCTGTCCTCTATAGAGAAGCAGTGCATGAGGCATGGGCTGAGGATGTTGATATGAGGGTCAACTTTGCAATGGACATTGGCAAAGCCCGTGGCTTTTTCAAGAGTGGGGATGTTGTGATCGTACTCACTGGCTGGCGGCCAGGCTCTGGTTTCACCAACACCATGCGTGTGGTTCCAGTGCCTTAATCTGAGAACCTGCTAACAAAACTCCAAATCTGTTGTCCCCTTTTTTCTGCACTCATCACCTTGCAGATATAAACTCTGAAGGCCAGATTATATACCCTTTATTTGTGGCATTGAGAGAGACATTAGTGTTTGTGCGCAGCACGGAATTCCATTGTTCCATTGCTTATTACACTCCCTGTGTTAGTCGGTTATTGCAAGTGCTGCCCACATATACATGGAAAGATGTGTAGCAATATCTGTAATTACACTCCTTTCTCAGCCCTTCACTTGTGCAAGAAATTGCCTTGGATGTGCAGTAAGTTTGCTCCTTATCTCTGGTCCGAGCAGCTGCGTAGTTTGTTTTGCTTGTGGTTAGGGGAAGGCTTTGTGTTGTCTTCATCCTGTCTGAGATGCACTGAGTTTAGTGTTAATAAATCAATGCTTATGCAGCCTCAAAAAAAAAAAAAA	Refseq >NM_001090872\|Xenopus laevis pyruvate kinase, muscle (pkm2), mRNA GCAGCTGTCATACGGTTGGTGAGGAGCGTGGATAGCTGCAGTGTTTGCTGGATTACGTAGATTCCATACAGTAGGTCAACATGTCTGAGGCAGGTAGTGCTTTCATTCAGACCCAGCAGCTGCATGCTGCCATGGCAGACACCTTCTTGGAACACATGTGCCGTCTAGACATAGACTCTGAGCCAATTGTAGCACGTAACACAGGCATCATCTGCACTATTGGCCCTGCTTCACGTTCTGTGGAAATGCTAAAGGAGATGATAAAATCTGGAATGAATATTGCTCGTCTGAACTTTTCCCATGGAACACACGAGTATCATGCTGGCACCATTAAAAATGTCCGTGAAGCAACCGAGAGCTTAGCTTCCAATCCCATTCACTACCGGCCTGTGGCAGTGGCCCTGGACACAAAGGGACCAGAAATCCGCACTGGTCTCATTAAAGGAAGTGGCACAGCAGAAGTGGAGCTAAAAAAGGGAGCAACTATGCGTATCACTCTTGATGATGCATTCCAGGAAAACTGTGATGAGAATGTACTGTGGGTAGATTACAAAAACCTTACAAAAGTGGTGAAACCTGGCAGCAAGATCTATGTGGATGATGGGCTTATTTCCTTGCTCGTTAAGGAAATTGGTCCAGACTTCTGCGTGACTGAGATTGAGAATGGGGGAATGTTAGGAAGTAAGAAAGGAGTGAACCTCCCTGGGGCAGCTGTGGATTTGCCTGCTGTATCTTCAAAAGATATCCAAGACCTGCAATTTGGTGTGGAGCAAGATGTCGACATGGTTTTTGCTTCTTTTATCAGAAAGGCAGCAGATGTACATGAAGTGAGGGAAGTTCTTGGAGAGAAAGGCAAAAACATCAAGATTATCAGCAAAATTGAAAACCACGAGGGTGTTCGCAGGTTTGATGAGATTCTAGAAGCAAGTGATGGTATAATGGTGGCACGTGGTGATCTTGGTATTGAGATCCCTGCCGAAAAAGTCTTCCTTGCTCAAAAGATGATGATTGGACGCTGCAATCGTGCTGGCAAACCTGTGATCTGCGCCACTCAGATGCTGGAAAGCATGATCAAAAAGCCTCGCCCAACACGTGCCGAAGGTAGTGATGTGGCCAATGCTGTTCTGGATGGGGCTGACTGTATAATGTTGTCAGGGGAGACTGCAAAGGGAGATTACCCATTGGAGGCTGTACGCATGCAGCATGCTATTGCACGAGAGGCAGAAGCGGCCATTTTCCATCGGCAGTTGTTTGAGGAACTGAGACGCGTGTCCCCACTGACCCGTGATCCCACAGAAGCGACTGCTGTTGGAGCAGTAGAGGCATCATTCAAATGCTCCAGTGGAGCCATCATCGTGCTTACTAAATCTGGCAGGTCTGCGCATTTACTGTCTCGTTACCGCCCACGCGCACCCATCATCTCTGTTACTCGTAATGGGCAGACAGCACGTCAGGCACATCTCTATCGTGGCATCTTTCCTGTACTCTATAGAGAAGCTGTGCACGAGGCATGGGCTGAGGATGTTGATAGCAGGGTCAACTTTGCAATGGACATTGGCAAGGCCCGTGGCTTTTTCAAGAGTGGGGATGTTGTGATCGTACTCACTGGCTGGCGGCCAGGCTCTGGTTTCACCAACACAATGCGTGTTGTTCCAGTGCCTTAATCTGCAAACCCGATAAAACTATAATCTGTTGTCCATTTTTTTTTCTGCACTCTCCACCCAGCAGATGTAAACTCTGTAGACCAGATTATAAACCCTTTATTTGTGGCATTGGGAGAGACATTAGTGTGTTTGTGCGCAGCACGGAATTCCATTGTTCCGTTGCTTATTACGATCCCTGTGTTAGTCGGTTATTGCAAGTGCTGCCCACATATACATGAGATGTGTAGAAATATCTGTAATTACACTCCTTTCTCAGCCCTTCACTTGTGCAAGAAATTGCCTTGGATGTGCAATAAGTTTGCTCTTCATCTCTAGTCCGAGCAGCTACGTAGTTTGTTTTGCTTGTGGTTAGGGGAAGGCTTTGTGTTGTCCTCATCCTGTCTGAGATGCACTGAGTTTAGTGTTAATAAATCGATGCTTATGCAGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001072532\|pyruvate kinase, muscle isoform 2 [Xenopus (Silurana) tropicalis] MSEAGSAFIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETGADFCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIALEAEAAAFHRQLFEELFRATASSKDPAEAMALGAVEASFKCLASALIVMTESGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPVP	Refseq >NP_001084341\|pyruvate kinase muscle isozyme [Xenopus laevis] MSEAGSAFIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEMLKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESLASNPIHYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATMRITLDDAFQENCDENVLWVDYKNLTKVVKPGSKIYVDDGLISLLVKEIGPDFCVTEIENGGMLGSKKGVNLPGAAVDLPAVSSKDIQDLQFGVEQDVDMVFASFIRKAADVHEVREVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVEASFKCSSGAIIVLTKSGRSAHLLSRYRPRAPIISVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDSRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPVP UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.373	Xl.21936 [+] Xl.4833 Xl.80636 Xl.34708
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PKM
mouse		MGI	Pkm	All(3) Spontaneous(1) Other(2)
zebrafish		ZFIN ZFIN	pkma pkmb

Publications
First:		In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase. [Proc Natl Acad Sci U S A 1978]
Most recent:		PKM zeta restricts dendritic arbor growth by filopodial and branch stabilization within the intact and awake developing brain. [J Neurosci 2009]
		View All Papers

Functional Ontologies
GO: Molecular:		pyruvate kinase activity
Biological:		glycolysis
Cellular Component:
EC:		pyruvate kinase
KOG:		[G] Pyruvate kinase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.373.1.S1_at [+] Str.44214.1.A1_at	Xl.21936.1.S1_at [+] Xl.4833.1.A1_at
Affymetrix 2.0			Xl2.21936.1.S1_at [+] Xl2.4833.1.A1_at Xl2.4833.1.A1_x_at

Symbol legend[+]