Gene Symbol: ins Gene Name: insulin Synonyms: preproinsulin, insulin I, ins1, xins, insulin Add Xenopus synonyms Gene Function: peptide hormone Interactants: igf1(67) , insr(50) , abcc8(39) , kcnj11(38) , gcg(37) , mapk1(34) , cdkn1a(30) View All

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 4.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001100236|Xenopus (Silurana) tropicalis insulin (ins), mRNA CCTCCTTTTGATCTTTCCAGCACTTGTCCAGCTCCCACTATCCTCTATCATGGCTCTTTGGATGCAGTGTCTGCCCCTGGTACTTGTGCTCCTTTTCTCTACACCCAACACCGAAGCTCTAGCTAACCAACACCTGTGTGGGTCTCACCTGGTAGAAGCCCTGTATCTAGTATGTGGGGATCGAGGCTTCTTCTACTACCCCAAGATCAAACGGGACATCGAACAAGCAATGGTCAATGGACCCCAGGACAACGAGTTGGATGGAATGCAGCTCCAGCCTCAGGAGTACCAGAAAATGAAGAGGGGAATTGTGGAGCAATGCTGCCACAGCACATGTTCTCTCTTCCAGCTGGAGAGCTACTGCAACTAGGGGACCAGGCAAATGCTCTCTTACCAAGGCACCTTCAAGGCAAATCCATTATGCCAAAACAACAGGACAACGAGCATTGTCTAACGGCACCAAGAACTTCTAACAATGTATATTTATTCCATATAAATTAGACATCGGTATCCCAACTAATCTGTTCTTAGTAGAAGGAGTTATATAGAGTAATTCTATGTGACAGGACAAGAAATATCTGTTATTTTTGCATTTTAATTTGCTCAGAAACCACCACTTTAATGCTACTTTAACATGGCTGTCATCAGCAAAGTACTGTGCAAGTCGGAAAGACCTTGTTTTAGGAGAGACCGGGCAGGTTACATTGATAAAGTTCAAAAAAGAAAGTATCTGGAAGAAAAAGAGCCACCCAAAATGTTATTCCGATCTTGCTTTTAAGTGCCTTGACCTACTGTATTTACTGTCTCTCTGTCTCACTGCAAATAAATGTAAGCTGAAGAGCTAAAAAAAAAAAAAAAAAAA	Refseq >NM_001085882|Xenopus laevis insulin (ins-a), mRNA ACCATGGCTCTATGGATGCAGTGTCTGCCCCTGGTTCTTGTCCTCTTTTTCTCTACACCCAACACCGAAGCTCTAGTTAACCAGCACTTGTGTGGGTCTCACCTGGTAGAAGCCCTGTACTTAGTATGTGGGGATCGAGGCTTCTTCTACTACCCTAAGGTCAAACGGGACATGGAACAAGCACTTGTCAGTGGACCCCAGGATAATGAGTTGGATGGAATGCAGCTCCAGCCTCAGGAGTATCAGAAAATGAAGAGGGGGATTGTGGAGCAATGTTGCCACAGCACATGTTCTCTCTTCCAGCTGGAGAGTTACTGCAACTAGGGGACCAGGCTAATGATCTCCAAGCAAGGCACCTTCAAGGCAATTCCATCATGCAAAAACACCAGGACAGAGAGCATGGTCTAACTGTGGATAAAATCTCTTTCTTCACATGTATATTTATTCCTTATAAATTACATCTGTATCCTAAATATTCTGTTTTTCTTCGAACGAGTTATATGGAATAATTGTAGGTGAGAGGAGAAGAAACATCTGTTATTTTTCCATTTTCATTTGCTCTGAAAGCACCACTCGCTATTGTAATGCTACAGGAAAGACCTGGTTTTAGGTGACAGGGCAGGTTACATTTATTAAGTTCAGATGTAAAAAAAAAAAAAATCTGGAAGAAAAAGAGCCACCCCAATTGTTAGTCCCATCTTGCTTTTAAGTGCCTGGGCCTACTGTATCTACTGCCTCTCTGTCTCAATGCAAATAAATATAAGCTAAAATGCT		Refseq >NM_001085881|Xenopus laevis insulin (ins-b), mRNA TCCTTTTGACCTTTTCCAGCACTTATCCAGCTCCCACTATCTTTTACAATGGCTCTATGGATGCAGTGTCTGCCCCTGGTTCTTGTCCTCCTTTTCTCTACACCCAACACCGAAGCTCTAGCCAACCAGCACTTGTGTGGGTCTCACCTAGTAGAAGCCCTGTACCTAGTATGTGGGGATAGAGGCTTCTTCTACTACCCTAAGATCAAACGGGACATCGAACAAGCACAGGTCAATGGACCCCAGGACAACGAGTTAGATGGAATGCAGTTCCAGCCTCAAGAGTATCAGAAAATGAAGAGGGGGATTGTGGAGCAATGCTGCCACAGCACATGTTCTCTCTTCCAGCTGGAGAACTACTGCAACTAGGGGACCTGGCAAATGCTCTCTTACAAGGCACCTTCAAGGCAATTCCATCATGCAAAAACATCAGGACAGAGAACGTGGTCTAACTGTGAATAAAATCTCTTTCTTTTCATGTATATTTATTCTATATCATTAGGCATGTGTTTCCCACACATTCTGTTGTTCCAAGAATGAGTTATGTGGAATAATTGTGGGTGAGAGAAGAAGAAATACAGTAGCTGTTATTTTTGTATTTTTCTTTTCTCAGAAAGCACCACCCACTATTGTACAAGCAGGAAAGACCTGGTTTTAGGTGAGAGTCAGGTTACATTGATTGGGTTCAGATGTAAAAAAAAAAAAAAACAAAATGAAAATCTAGAAGTAAAGAGCAGCCTCAAATGTTATTCCCATCTTGCTTTTCATTGCCTGGACCTATTATATCTGTTGCCTCTCTGTCTCAATGCAAATAAATGTAAGCTCACGCCTTCTGTGTTATTGAACTGCGCTACTGTCCCTATAATACATATGATTTATATATCCATT
Protein		Refseq >NP_001093706|insulin [Xenopus (Silurana) tropicalis] MALWMQCLPLVLVLLFSTPNTEALANQHLCGSHLVEALYLVCGDRGFFYYPKIKRDIEQAMVNGPQDNELDGMQLQPQEYQKMKRGIVEQCCHSTCSLFQLESYCN	Refseq >NP_001079351|insulin-1 precursor [Xenopus laevis] MALWMQCLPLVLVLFFSTPNTEALVNQHLCGSHLVEALYLVCGDRGFFYYPKVKRDMEQALVSGPQDNELDGMQLQPQEYQKMKRGIVEQCCHSTCSLFQLESYCN UniProtKB		Refseq >NP_001079350|insulin-2 precursor [Xenopus laevis] MALWMQCLPLVLVLLFSTPNTEALANQHLCGSHLVEALYLVCGDRGFFYYPKIKRDIEQAQVNGPQDNELDGMQFQPQEYQKMKRGIVEQCCHSTCSLFQLENYCN UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase JGI Ensembl UCSC			Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.29324	Xl.817		Xl.23623
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		22 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	INS	OMIM:125850 OMIM:147510
mouse		MGI	Ins2	All(16) Targeted, knock Out(3) Targeted, other(10) Chemically Induced(1) Spontaneous(1)
zebrafish		ZFIN	ins

Publications
First:		Translation of messenger ribonucleic acid from isolated pancreatic islets and human insulinomas. [Proc Natl Acad Sci U S A 1975]
Most recent:		Frog skin peptides (tigerinin-1R, magainin-AM1, -AM2, CPF-AM1, and PGla-AM1) stimulate secretion of glucagon-like peptide 1 (GLP-1) by GLUTag cells. [Biochem Biophys Res Commun 2013]
		View All Papers 18 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		hormone activity
Biological:		physiological process
Cellular Component:		extracellular region
EC:
KOG:

Reagents		tropicalis	laevis a		laevis b
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.29324.1.S1_at	Xl.817.1.S1_at		Xl.23623.1.S1_at
Affymetrix 2.0			Xl2.817.1.S1_at		Xl2.23623.1.S1_at

Symbol legend[+]

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