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Summary Expression Gene Literature (41) GO Terms (16) Nucleotides (1696) Proteins (70) Interactants (828) Wiki
XB-GENEPAGE-485945
Gene Symbol:
tpm1

Gene Name:
tropomyosin 1

Synonyms:
alpha-tm , alpha-tropomyosin , CH1 ( Add synonyms , Nomenclature history )

Gene Function:
actin filament coating

Protein Function :
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. S...[+]


InterPro :
Znf C2H2 sf , B30.2/SPRY , ConA-like dom sf , Butyrophylin SPRY [+]

Interactants:
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Diseases: 


Disease Ontology:
left ventricular noncompaction [+]

OMIM:
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3; CMH3 [+]

External Links:
 
Xenbase Gene ID XB-GENE-485946 XB-GENE-865564 XB-GENE-17332885
Gene Symbol tpm1 tpm1.L tpm1.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model
Entrez Gene 448541
100189579
mRNA RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tpm1 tpm1.L tpm1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TPM1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tpm1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tpm1 Ensembl
zebrafish
ZFIN, AGR tpm1 ZFIN Ensembl
chicken
GEISHA TPM1 Ensembl
fruit fly
worm
Publications
First Monoclonal antibodies against chicken tropomyosin isoforms: production, characterization, and application., Hybridoma 1985  
Most Recent Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis., Aquat Toxicol 2020  
All View All Papers 10 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 8 terms 0 term
PANTHER tpm1
KEGG Pathways K10373 K10373
KOG [Z] Actin filament-coating protein tropomyosin
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tpm1
Antibodies Tpm1 Ab1 Tpm1 Ab1 Tpm1 Ab1
Morpholinos (on-target & off-target) tpm1 MO2 , tpm1 MO3 tpm1 MO1 , tpm1 MO2 , tpm1 MO3
ORFs tpm1 ORF1 tpm1.L ORF1 , tpm1.L ORF2
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info