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Summary Expression Gene Literature (52) GO Terms (35) Nucleotides (175) Proteins (42) Interactants (793) Wiki
XB-GENEPAGE-486816
Gene Symbol:
irx1

Gene Name:
iroquois homeobox 1

Synonyms:
Xiro , Xiro1 , irx1-a , irx1-b , iro ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural...[+]



Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-486817 XB-GENE-865648 XB-GENE-6254076
Gene Symbol irx1 irx1.L irx1.S
Chromosome Chr06 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100038208
397976
735237
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irx1 irx1.L irx1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IRX1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irx1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irx1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR irx1a irx1b ZFIN Ensembl
chicken
GEISHA IRX1 Ensembl
fruit fly
worm
Publications
First Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate., EMBO J 1998  
Most Recent Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development., Dis Model Mech 2020                                  
All View All Papers 7 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 33 terms 24 terms 21 terms
PANTHER irx1
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irx1
Morpholinos irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2 irx1 MO1 , Irx1 MO2
ORFs irx1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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Version: 4.15.0
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