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Summary Expression Gene Literature (41) GO Terms (14) Nucleotides (219) Proteins (46) Interactants (797) Wiki
XB-GENEPAGE-486940
Gene Symbol:
prickle1

Gene Name:
prickle planar cell polarity protein 1

Synonyms:
prickle , XPk , Prickle-b , XPk-1 , prickle1-b , prickle1-a , prickle A , prickle B ( Add synonyms , Nomenclature history )

Gene Function:
nuclear receptor, may be a negative regulator of the Wnt/beta-catenin signaling pathway [Entrez]

Protein Function :
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastru...[+]


InterPro :
Glyco trans 1 , GPCR 2 extracellular dom , GCPR 2 calcitonin rcpt fam , GPCR 2 extracell dom sf [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Unverricht-Lundborg syndrome [+]

OMIM:
EPILEPSY, PROGRESSIVE MYOCLONIC, 1B; EPM1B

External Links:
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Xenbase Gene ID XB-GENE-486941 XB-GENE-6251800 XB-GENE-865659
Gene Symbol prickle1 prickle1.L prickle1.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549693
398264
398256
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine prickle1 prickle1.L prickle1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards PRICKLE1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Prickle1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Prickle1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR prickle1a prickle1b ZFIN Ensembl
chicken
GEISHA PRICKLE1 Ensembl
fruit fly
Publications
First The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity., J Pathol 1996  
Most Recent Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020                        
All View All Papers 5 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 14 terms 4 terms 6 terms
PANTHER prickle1
KEGG Pathways K04511 K04511 K04511
KOG [TZR] FOG: LIM domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks prickle1
Mutants Xla.prickle1emHorb
Morpholinos prickle1 MO2 , prickle1 MO1 prickle1 MO2 , prickle1 MO1
ORFs prickle1.L ORF1 prickle1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info