gdf3 Summary [species: Xenopus laevis and Xenopus tropicalis]

Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymm...[+]

InterPro

TGF-b propeptide , TGF-beta-rel , Cystine-knot cytokine , TGF-b C [+]

Interactants:

Loading ...

Diseases:

Disease Ontology:

isolated microphthalmia 7 [+]

OMIM:

KLIPPEL-FEIL SYNDROME 3, AUTOSOMAL DOMINANT; KFS3 [+]

External Links:

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD

1/2

Xenbase Gene ID

XB-GENE-487309

XB-GENE-17343554

XB-GENE-865693

Gene Symbol

gdf3

gdf3.L

gdf3.S

Chromosome

Chr01

Scaffold21

Molecules

X. tropicalis

X. laevis.L

X. laevis.S

Genomic Sequence

Version 9.1

>gdf3 9.1 
							CTGAAAGCAACATGGAAGGGATGATGCTCTCACTCGCTtgctttttctcctttcttttaatGGTGAAATCCTCTCCACTCACCTTCCAGGAAAGAATGCTCCTCAAAGCCTTGGGGCTGAACACCAGACCAAACCCCATTGCTCCAGGTCCTGTACCTAAGTCTTTAAGAGACATTTTTGAGAAGGGGATAAACAAGGACAACCCCTGCATGATGGAAGGTTTTGGGGTACCCGGAAATATTGTCCGCTCATATCGAGATCAAGGTAAGTGAGGGAATCCTGTAGGATAAGGATTTGTAATTTGAAACTTGTCATTTATATAGTTATTAGTGTATAGTCAGACAAAGATTATGTAACTAACCAGAAAATGAGAGGTTATCCAAAATGCAGTGCTGAAAAGTGTTTACAATTAATGAACTATAAATACTGTGTGTAGGCACCATTGTTTGAGGGCATATTTTGATCTGGTACCTCTCCGTGTATGACATAAATTAAGCCAGACACACCAGCCTGCTGGCAAGATAAACCAGACTTCCAGTGTAGGTACTTAAACATGGCACCTTCATTAGAAAATGAAGGGGTGTACAATTTAAATGTAAGTGTTTGACTAGTAGTGCAAACAAAGTATTTGAACACGTGGTAAAAAGTGAAAAAGGGAGCTTTAACTTTAATGCATTCTGCCTGTCCGTTTAATAATAACAGTTATAATCACTAATGACTGTCCTATTGTACTTCTGTACAGAAAATACCTCTGAGTCTGCCAGTGTATACCCAGCACTGGATAGATCGTTTTGCTGGTGTGCACCCACTCCTAACCTATTGTTTATAAGCATGCACTGACTGGAGGGAGGAGTACCCTACTCAGCACCTATTATGGAATATACCTACTTTTTCTGTCGACTTGGTAACCAGTGTTATCTGGTTCTCTCCTGACATGTACATAAATATGCTTAAAAGATATGATGAAAGTGTTTGTAAATCTTTTAAGAACAAGATTATATAAGATCATAATTAACAGTTGTCCATTTTTCATCTTTCTCCTAGGACCTGTAGCAGCCATGGAGGAGCCACAAGAATCACTGTGCTTAAAGAAATTTCTCTTTTTTGACCTATCAGCAGTGGAGAATAAGGAGCAACTGACCCTAGGCCAACTGGAAATTAAGTTCAAGCACAACTCGTATTATGGACAACAGTTCCATCTGCGCCTCTACCGCACCCTTCAGCTATCTCTAAAGGGTATGAGAGAGAGCAAGATGAACAGGAAGCTTCTAGTGTCACAGTCTTTCCGGCTTCTTCATAAGTCCCTCTATTTTAACCTGACCAAGGTGGCAAAGGACTGGAAAACCCCTGAGAAGAATATGGGACTGTTATTGGAGATATATGCTAGCAGTAAACTTGCAGGAGACAACAGATCATTTGCAGTGTGTGAACCAATCCAGTCTTTCATTTACACTTCTCTGCTCACTGTGTCTCTAGAcccatccagctgcaaaactcCGCGAGCCAAGAGAAGTACTCATTCATCGCCTCCAACCCCAAGTAATATCTGCAAAAAGAGGCGCCTGTACATTGACTTCAAGGATGTTGGATGGCAGAACTGGGTGATTGCACCCCGTGGTTACATGGCCAACTACTGCTATGGAGAGTGCCCCTATCCACTGACAGAAATGCTCAGGGGCACAAATCATGCTGTTTTGCAGACTCTGGTGCATTCTGTAGAACCAGAAAGCACCCCTTTGCCTTGCTGTGCCCCCACTAAGCTGTCTCCTATCTCCATGCTATATTATGACAACAATGACAATGTGGTACTGAGGCACTATGAAGATATGGTAGTAGATGAATGTGGTTGCAAGTGAGTTTGGCTAGGACTACTCTTCTCATTAAACTTATTGTCTAAGGGACTGCTGGCAACTTAATCATGGAGTGATTCTCCTTGTGTGACAGTGGCTTTGACCATTAGTGTTCAGCTACAATTCCCCCCATGAAGCAAGATAGGCTTCTGTTAGCTAGAAATTGTAACATTCGTACCAGGAAATGTATTCCCATAAAAACAGAgactatattttttgtaaaacctGTTTCTCCCCAATAACATTAATATGCACAAATTTTATGCATTGTTTTTAGCTAAAATTCAGATTCTTTGGCATATGCTAGGCACAGGAAGCAAAACAAAAGTTGCCCTTTAGGTGGATGGGCCACTTTCATTTGTGACTTTTAACAGAGCTACAGGATGAAATGCTTTGCAAAATGACTACTGCTCTCAAtttctttatgtatgtatatattgggCATATGGCTAGGTTGGTGCCCAAGAACTGGCCTGCACTTGTTGCTTTGCTCTTGAACTGTTAAGACTAATGTTTAAATACAGTTGATTGttgtaaataaaatgtgatttaacattcttattttcatttatttcattttttcagtAGGGGAAATACATTGGGTTGCCTAATTGTGAGCTGTTACTCCTCACACAAGAAGGGTGGTGGAGAGTAGTAGCAGCAGCTTTAAGGTAGCACAGCCATTGCACCATTACACTATTGCATGTCGATTTAAAGGtcactggtaaaaatgatgctttgtGCCAATGTGCTTTATACCCCCATTCAAAATAATTTAGACTTCTCATAAATACACTGATTGTTGttgtaattataaaaaatgtgtggtgtttgttatttcttgctatTAAGCTTTCATATTCTCAAATTCCTGGCTCTTCGTAGATAATTCAACTACCAGCCTAAAGATAAACCCCCTGCAAAATGGACTTCTGCATATCTGTAAAACcgaaacagtcacaacaaaaagAGGGGCAgggattgtttatacagagttGATTGTCTCTATCTAAATTTACTCAGCTAATTGCTGGAGGGCTTTTAAGCGTGAAAGCAAAGCATGCAATTCTTCATTAATTACCTACACCCCAGTGATGTCTTTTAAATATAGCAATGTGAGAATATTTTTACACAGAAGTAAATGAAGGGCCTCTGCACAACAAGGGAATACACAATGTACACCTACCGTTTAATTTTCTCTCCCTCACATCATCACAAAAAGTCAAATCatgtagattatatatatatatatatatatacacgcacacgATTAAAACAGCAGCacttctttaatatatataattatagtttgTAAAATCCCCCTATATGGCAATGTGTCAGAATACAAACAACCCTTCCTCAAGCCAGAGGTGCAATTATAGATCACTTGCAAATTAATATTGCTTTATTGGCTTTTAAAGGGAAAGACAgctaagggcttatttatcaatatttgtgttgttttcatatttttcctaCTTTTAATAccctaaaaatgttaaaaaaaaatctgtattagaTAAATGTGATTGACCAAAACCATTAATTAATTTGAATTTCTTAAATGCTAcatttttgcatcatttttaaGAGGTCATAAAGTTGGaaagaaaaaattcaaaaatttgaatAGTTAAAATTTTGCAGTTCCCAATGACTTCTATGTGACCTTCTTTAGAagatttacatttgcattttttgtgttcttttttacttaataaatagTGAaagtttg

Version 9.2

>gdf3.S 9.2 
							GGCAGAAGCTCCAAGGCAGAAGTGCAGACCTACATGAGAAGTCAACATGGCAGAGTTGTGGCTATCACTTTCTTGCATGTTCTCCTTGCTTCTACTGACAAATTCATCTCCACTTACCTTCCAGGAAAGAATGCTCCTTAAAGCCTTGGGGCTGAACACCAGACCAAACCCCATTGCTCCAGCTCCTGTACCTAAATCTTTAAGAGAAATTTTTGAGAAGGGGATAAACCAGGACAATCCCTGCATGATGGAAGGTTTCGGAGTACCTGGAAATATTGTCCGCTCATATCGAGATCAAGGTAAGTGAGGAAAGAGGTGTGGGATGGCAGTTgaaggtttcttatttaaaaCCTATAGAGAGGGTACCATTTTACTATTGCTAGTTTATTTAACCCCTCCCTTACTTTCTCTCTAGGATACATATGCCGGTTTTAGAACTTTGAATGGTTATTTGgttattttctggcttttttatcTTATCTGTAATAATTGCTGGAAAGTAAAAGTGTTGTTTGCTTAAAGTGTTGTGGTGATGTTTTTTAAAAGctgcaatgtttttttggccAGGAGTGCATTCATAATGGATAATTATTTATAGCACCTTCATCAGCAGATGTGGGTGTAGAGGTGTACAATTCAAAAGTCCAATAATTGGCAttcctaagcaactttcctatatacCTAATTATACATTTCCAAtggtttgaaagttatttgtataattattttaagCCATATTTATCCCTATTCTGTCTTTCTATATGACTGCAagacaaaatgttaaataattaatAGGACACAAAAGAGGAAATCTATTAAATGCTAATGGTACAAAAGGTTAATATTGATGGGACTATCCCTTTAGGCTCAAGATTTTACATCGCAAGACATTCTGTTATTTCTATAGTTGTATGTATTCAGTTCTGCAATCACTGCCCTCAGGTAACAtaacaccatctagtggtcactTATATAATTTAACAAAACAGTTCACCCTATGAAGAATGCATCACATGAGGCAAATAAATGGGGGCTTCAACCTTTAACTATTCTGCCTGAACAGAACCCCCTCTgattatgaaatatatttctctattcctttttgtttttgcagtgtAGAGCACCCTGTTTCTCTAGAATTGTTTTTGACTTCCTTTGTGTCTTTCCATATATGCATGTTAATATATGAGCTGATAACTAACAGacatctatttttctattttctcctAGGAACCATAGCAGCCATAGAGGAGCCACAAGGATCTCTGTGCTTAAAGAAATTTCTCTTTTTTGACCTATCAGCAGTGGAGAACAAGGAGCAATTGACCCTAGGCCAACTGGAAATTAAGTTCAAGCACAACACATATTATGGACAACAGTTCCATCTCCGCCTCTACCGCACCCTTCAGCTATCTCTAAAAGGGATGAGAGACAGCAAGATGAACAGGAAGCTCCTGGTGACTCAGTCTTTCCGTCTCCTTCACAAGTCCCTCTATTTCAACTTGACCAAGGTGGCAGAGGACTGGAAAAACCCTGAGAAGAATATGGGTCTGATACTGGAAATATATGCAAGCAGTGAACTTGCAGGAGGCAATCGATCATTTGTAGTATGTGAACCAATACAGTCTTTCATTTACACTTCTCTGCTCACTGTGTCCCTAGACCCATCCAATTGCAAAACTCAACGAGCCAAGAGGAGTACTCATTCATCACCTCCAACCCCAAGCAATATCTGCAAGAAAAGGAGATTGTACATTGACTTCAAGGATGTTGGATGGCAGAACTGGGTCATTGCACCCCGTGGTTACATGGCAAACTACTGCCATGGAGAGTGCCCCTATCCACTGACGGAAATGCTAAGGGGCACAAATCATGCTGTTTTACAGACTCTGGTGCATTCTGTAGAACCAGAAAACACCCCATTGCCTTGCTGTGCCCCCACTAAGCTGTCTCCTATCTCCATGCTATATTATGACAACAATGACAATGTGGTACTGAGGCACTATGAAGATATGGTAGTGGATGAGTGTGGTTGCAAGTGAGTTTGCTTTGGAGATTGTTCTCATTCCCTTATCTAAGCCTTAAACTTATCCTCTAAAGGGACTGCTGCCAACCTAGTTATGAAGCCTCGCGCCTCGTGCGACAGTGACTTTAACCATCTTACATAACATTAATtgataagactatatttattttggggtgtaCTTGCCCTTTAGGTGGTTTGGCAAATGCCATGCGTGGCTCTTAACAGAGCTGCTGgatgaaacacatttttaaaaaagtatattgttgtcaataaatgtttttatctttatatattgGGCATAGAGCTAGGTTGGTGCCTGAAAATTGCCTAGCACTTGCAAGTACAGCTGATTGTtggaaataaatgtgatttaaCAAATTTGTTTGCATTTGATTACTTAATTTTTGCTGTAGGGGGAAATGTATCGGGTTGCATACATATTttaaagatgatgatgatgctgtTACTCCTCACACAGAGTAGGAAGTTGTAATAGCAGCTTTTAAGCAGCACAGATATTATAGTCCACATAGGTGTAGTCATGGGTGTCTAGAACATTTTTTTGGCGGGGGTTTGGAGTCatcaaagaaaagcaaactgTCTTTCTAAAGCTAAGCTGGGATACAAGATAATTATAGGTACCGATTTATTGGCAAAGCCCACAAAGTCACTCACTACCTACACAATTGTATAACTGGGGGGACTAATTATTTAGAAAGTATAACCATGAAAGTCTGACACATGCAGTGCTGCAATAATCTGAGATATATCAGTATAATTGCTACAGCAAATGGGTATtctgcatattaaccccagagAGGCCAGAATAATTACTGAGGAAAATTGATAATCTACATCAGGGCTGTCTAACTAGTGGCCCACAGAcggacccccccccctttgtgtgTCCCCCATGAAAACCtggtgtaaactttaaaaggtatcagtattgagattaattggcccctgcagtGTTTACACCTTAAATTCAGACATGAAATCAAACCTTTAACATTTCTATTGTTAAcatccctatgctccctgtttgtgccatactctgcctgctctatgctatgtgtgtgccatacactgcctgccttAACCTGTACCTTGTGGGACGCGAGCCTGGTAGcctggggtttgttagcatttggaaattattgttaggg

CDS

Gene model

Entrez Gene

493288

394305

mRNA

RefSeq

Protein

RefSeq

Swiss-Prot

More..

RefSeq

Swiss-Prot

More..

Genomic

X. tropicalis

X. laevis.L

X. laevis.S

Genome Browser

(Click image to open in Genome Browser)

Genomic Synteny

Genomicus PANTHER

Expression

Development Stages

Embryonic Tissues

Adult Tissues

Summary for

More Information

Xenbase Expression Details

In situ images

Single cell data at SPRING

Ensembl

Proteomics

X. tropicalis

X. laevis.L

X. laevis.S

Embryonic Protein Expression

Stage profile:

Data Mining

X. tropicalis

X. laevis.L

X. laevis.S

XenMine

gdf3

gdf3.L

gdf3.S

Orthology

Knowledgebases

Entrez Gene

Genetic Phenotypes

Gene Expression

human

HGNC AGR, OMIM:Gene, GeneCards

GDF3

OMIM

Ensembl, Allen Brain Atlas, Protein Atlas

mouse

MGI, AGR

Gdf3

MGI, IMPC

Ensembl, Allen Brain Atlas, Eurexpress, MGI

rat

RGD, AGR

Gdf3

Ensembl

zebrafish

ZFIN, AGR

gdf3

ZFIN

Ensembl

chicken

GEISHA

GDF3

Ensembl

fruit fly

worm

Publications

First

Identification and cloning of localized maternal RNAs from Xenopus eggs., Cell 1985

Most Recent

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network., Elife 2020

All

View All Papers 11 paper(s) referencing morpholinos 3 paper(s) referencing Disease Ontology

Functional Ontologies

X. tropicalis

X. laevis.L

X. laevis.S

25 terms

0 term

16 terms

PANTHER

gdf3

KEGG Pathways

K05495 [+]

KOG

[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Reagents

X. tropicalis

X. laevis.L

X. laevis.S

CRISPRscan Tracks

gdf3

Antibodies

Gdf3 Ab1

Morpholinos

gdf3 MO1

ORFs

gdf3 ORF1

Clones

EXRC Horizon Source BioScience

Horizon Source BioScience

Plasmids

Addgene

Symbol legend:

Blast sequence

View sequence

Literature or expression images

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