foxa1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (19)

Nucleotides (168)

Interactants (91)

XB-GENEPAGE-487351

Gene Symbol: foxa1 Gene Name: forkhead box A1 Synonyms: xfkh2, HNF3alpha, HNF-3 alpha, HNF3 alpha, HNF3-alpha, tFoxA1, hnf3a, tcf3a Add Xenopus synonyms Gene Function: forkhead domain transcription factor Interactants: nr3c1(4) , dkk1(3) , foxa4(3) , hhex(3) , pdx1(3) , sox17a(3) , egr2(2) View All	1/4

XB-GENE-487352

XB-GENE-487356

XB-GENE-6256649

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_204088\|Xenopus (Silurana) tropicalis forkhead box A1 (foxa1), mRNA GCTAGCGCTCCGGGACTCTCCTACTGAGCTGGCAGCGCCCCCCGCACGGTGCTGCCTCTTCTCTCCCTGCCACTCGAACTACTCGCTGGCTGAATGTTTCTCTCGGGCACTTGCGATCCAGGATGTTAGGAATAGTTAAAATGGAAGGACATGAGACGACAGATTGGAGCAACTATTACCAGGACACCCAGGAGGCCTATTCCTCAGTTCCGGTCAGCAACATGACCCAGGGGCTGGCATCCATGAATACCTACATGACTATGAACCCCATGAGCTCCAGCAGCAACATGACAGCAGGCTCCTTCAATATGTCCTATGCCAACTCAGGCTTGGGAGCGGGACTGAGCCCTAGTGGCATGTCTGGCATGGGAGCGGGATCCGCCAGTGCTATGAACGGTATGGGCTCTGGGGTGTCCTCCATGGGCACCGCTCTGAGCCCCTCCAGTATGAACGCAATGTCAGCGCAACAAGCCTCCATTAACAGCTTGTCCTATTCCGGCATGAACCCAGGAATGAGCCCCATGGCATACGGGCCATCCAACATGAACAGGACAAGGGACACGAAAACATTCCGGAGAAGTTACCCCCATGCCAAACCCCCTTACTCCTACATCTCACTGATCACCATGGCCATCCAACAGGCCCCCAGCAAAATGCTGACTCTCAGTGAGATCTATCAATGGATCATGGACCTTTTTCTATACTACAGACAGAACCAGCAGCGCTGGCAGAACTCCATCAGGCACTCCCTGTCCTTTAATGACTGCTTTGTTAAGGTGGCCAGGTCCCCAGACAAGCCAGGCAAAGGCTCTTACTGGACCTTGCACCCCGATTCCGGGAACATGTTTGAGAATGGCTGCTATCTTCGTAGGCAAAAGCGATTTAAGTGCGAGAAACAACAAGGGGGGAAAGGCAGCCAAGATGGCAGGAAAGATGTTTCTGGCCCTTCGTCCCCTTTGCACCGGGTACATGGCAAATCCAGCCAGATGGACAGCAGCTCCTCCATGTCCAACCCTTCCAGCAGCCCTCAGTCCTTGGAACACAATGGTTCTAATGGGGAGATGAAACCACAAGTAGCAGCTGGTCCTTCTCCCCTCTCTTCCCACCAGAACCACTCTACTCACTCCTTGGCCCATGAAACCCATATACACCTTAAGGGAGACCCCCATTATTCCTTCAACCATCCATTTTCCATCAACAACTTAATGTCATCTTCGGAGCAACAGCACAAACTGGACTTCAAAGCCTATGAGCAGGCTCTTCAGCAGTATTCCTCCTATAGTGGGGGACTCCCAGGGATGCCTTTGGGTAGCCCATCTATGGCTGGGAGAGGGAGCATTGAACCTTCCGCTCTGGAACCCACTTACTACCAAGGGGTGTATTCCAGGCCTGTGCTAAACACTTCCTAGGACCAGTAACATTCTCCTGGAAAATGTGGTGGGCTTTGCTTTCTTCAGATCGGGACTGTTACCTAAATAGTGTATCGATATAAAAAAGGGATTATACATATGTTATTTTAAACAGGAAAAGTGAAAACGTAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001105271\|Xenopus laevis forkhead box A1 (foxa1-a), mRNA GTGTGTGTGGGTACGAGGCAGGTGTAGCTGGGACTTTGTGTAGCTGGGACTTTGCTGCCAGTAGCGAATGGAGGCAAGGAGTTGAGGAGGGAGGGAAGAAGAGGAGGAGAGAGGGGAAAGGAGGGAAGTCCCTTCCCAGCCGCCAGATCCACATCAGCTTTGCCCTGGCACTGCACCTCCCGGGGACTCTCCTGCTAAACTGGCAGCGCCCCCCGCGCTGTCTCTTCTTTCCCTGCCGCTCCAACGACTCGCTGGCTGAATGATTCTCTCGGGCACTTGCCATCCAGGATGTTAGGAATTGTCAAAATGGAAGGACATGAGACGACAGATTGGAGCAACTATTACCAGGACACCCAGGAGGCCTATTCTTCAGTTCCGGTCAGCAACATGACCCAGGGCTTGGCTTCCATGAATACCTACATGACTATGAATCCCATGAGCTCCAGCAGCAACATGACAGCAGCAGGTTCCTTTAATATGTCTTACGGCAACTCAGGCTTGGGAGCGGGACTGAGCCCTAGTGGTATGTCTGGCATGGGAGCGGGAGCCGCCAGTGCTATGAATGGTATGGGGTCTGGAGTCCCCTCTATGGGCACCGCTCTGAGCCCCTCCAATATGAACGCTATGTCAGCCCAACAAGCCTCAATGAACAGTTTGTCCTATTCCAGTATGAACCCGGGTATGAGCCCCATGGCATACGGGTCGTCCAACATGAACAGGGCAAGGGACACTAAGACATTCCGGAGAAGTTACCCCCACGCGAAACCCCCTTACTCCTACATCTCACTGATCACCATGGCCATTCAGCAGGCGCCCAGCAAAATGCTGACTCTCAGTGAGATCTACCAGTGGATCATGGACCTTTTCCCGTACTACAGGCAAAACCAGTAGCGCTGGCAGAACTCCATCAGGCACTCCCTGTCCTTCAATGACTGCTTTGTTAAGGTGGCCAGGTCCCCAGACAAGCCGGGCAAAGGCTCTTACTGGACCTTGCACCCCGATTCCGGGAACATGTTTGAGAATGGTTGCTATCTTCGTAGGCAGAAGCGATTTAAGTGTGAGAAAACGCAAGGGGGGAAAGGCAACCAAGATGGCAGGAAAGATCATTCTGGCCCATCGTCTCCATTGCAGCGGGTACATGGCAAATCCAGCCAGATGGACAGCAGCTCCTCCATGTCCAACCCTTCCAGTAGCCCTCAAGCCTTGGAACACAATGGTTCTAATGGGGAGATGAAACCACAGGTTGCAGCAGGTCCTTCTCCCCTTTCTTCCCACCAGAACCACTCTACTCACTCCTTGGCCCATGAATCCCATATTCACCTCAAGGGAGACCCCCATTATTCCTTCAACCATCCATTCTCCATCAACAATTTAATGTCATCTTCAGAGCAACAGCACAAACTGGACTTCAAAGCATATGAGCAGGCTCTTCAGCAGTATTCCTCTTATGGAGGGGGACTCCCAGGGATGCCTTTAGGCAGCCCCTCCATGTCTGGGAGAGGGAACATTGAACCTTCAGCCCTGGAACCCACATACTACCAAGGGGTGTACTCCAGGCCTGTCCTAAACACCTCATAGGACCAGTAGTATTCTCCTGGAAAAATTCAGTGGGCTTGGCTTTCTTCAGATCTGGACTGTTACCTAAATAGTGTATCGATATAAAAAAAAAGGGATTATACATATGTTATTTTAAACAAGAAAATTAAAAAGTAAAAAAACAAAAAAAAAAAAAAA		Refseq >NM_001086594\|Xenopus laevis forkhead box A1 (foxa1-b), mRNA GGGGACTCTTCTGCTAAACTGCCAGCGACAAACTGCCAGCGACAAACTGCCGACGCACGGTGCTGCCTCTTCTCTGTCACTCGAACGACTCGCGGGCTGAATGTTTCTCTCGGGCACTTGCGATCCAGGAATATGTTAGGAATAGTAAAAATGGAAGGACATGAGACGACAGATTGGAGCAACTATTACCAGGACGCCCAGGAGGGCTATTCTTCAGTGCCGGTCAGTAACATGCCCCAGGGCTTGGCCACTATGAACACTTACATGACTATGAATCCCATGAGCTCCGGCAGTAACATCACATCAGGCTCATTTAATATGCCCTATGGCAACTCCGGCCTGGGAGCGGGACTGAGCCCCAGTGGAATGTCTGGAATGGGATCAGCCGGTGCAATGAATGGAATGGGGTCTGGAGTCCCCTCTATGGGCAGCGCTCTGAGCCCCTCTAATATGAACGCCATCCAATCAGCCCAACAAGCCTCAATGAACTCTTTGTCCTATTCCAGCATGAACTCGGGCATGAGCCCCATGGGCTACGGGGCGACCAATATTAACAGGACAAGGGACAGCAAAACGTTCCGGAGAAGTTACCCCCACGCGAAACCCCCTTATTCGTACATCTCTCTGATCACCATGGCCATTCAGCAGGCGCCCAGTAAAATGCTGACTCTGAGCGAGATCTACCAGTGGATCATGGACCTGTTTCCCTACTACCGGCAAAACCAGCAGCGCTGGCAGAACTCCATCAGGCACTCCCTGTCCTTCAACGACTGCTTTATTAAGGTCTCCAGGTCCCCAGACAAGCCGGGCAAAGGCTCTTACTGGACTTTGCACCCCGATTCTGGGAACATGTTTGAGAATGGCTGTTACCTCCGCAGGCAGAAGCGATTTAAATGCGAGAAAACGCAAGGGGGGAAAGGCAACCAAGATGGCAGGAAAGATCATTCTGGTCCATCGTCTCCATTGCACCGGGTCCATGGCAAGTCCAGCCAGATGGACAGCAGTTCCTCCATGTCCAACCCTTCCAGTAGCCCTCAAGCCTTGGAACACAACGGTTCTAATGGGGAGATGAAACCTCAAGTAGCAGCTGGTCCTTCTCCTCTTTCTTCTCACCAGAACCACTCTACTCACTCATTGGCCCATGAAACCCATATTCACCTCAAGGGAGACCCCCATTATTCCTTCAACCACCCATTCTCCATTAACAATTTAATGTCATCCTCAGAGCAACAGCACAAACTGGACTTCAAAGCCTATGAGCAGGCTCTCCAGCAGTATTCCTCTTATGGTGGGGGGCTCCAAGGAATGCCTTTGGGGAGCCCCTCTATGACTGGGAGAGGGACCATTGAACCTTCAGCCCTGGAACCCACATACTACCAAGGGGTGTATTCCAGGCCTGTCCTAAACACCTCCTAGGACCAGCAACATTCTCCTGGGAACATTGGGTGGCCTTTGATTTCTTCACATCAAGACTGTTACCTGAATAAAGTCTCCATATAAATAAGGGGTTCAAATATGTTATTTTAAACAAAAAAAAAAAAAAA
Protein		Refseq >NP_989419\|forkhead box protein A1 [Xenopus (Silurana) tropicalis] MLGIVKMEGHETTDWSNYYQDTQEAYSSVPVSNMTQGLASMNTYMTMNPMSSSSNMTAGSFNMSYANSGLGAGLSPSGMSGMGAGSASAMNGMGSGVSSMGTALSPSSMNAMSAQQASINSLSYSGMNPGMSPMAYGPSNMNRTRDTKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFLYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQQGGKGSQDGRKDVSGPSSPLHRVHGKSSQMDSSSSMSNPSSSPQSLEHNGSNGEMKPQVAAGPSPLSSHQNHSTHSLAHETHIHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQQYSSYSGGLPGMPLGSPSMAGRGSIEPSALEPTYYQGVYSRPVLNTS UniProtKB	Refseq >NP_001098741\|forkhead box A1 [Xenopus laevis] MLGIVKMEGHETTDWSNYYQDTQEAYSSVPVSNMTQGLASMNTYMTMNPMSSSSNMTAAGSFNMSYGNSGLGAGLSPSGMSGMGAGAASAMNGMGSGVPSMGTALSPSNMNAMSAQQASMNSLSYSSMNPGMSPMAYGSSNMNRARDTKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQ		Refseq >NP_001080063\|forkhead box protein A1-B [Xenopus laevis] MLGIVKMEGHETTDWSNYYQDAQEGYSSVPVSNMPQGLATMNTYMTMNPMSSGSNITSGSFNMPYGNSGLGAGLSPSGMSGMGSAGAMNGMGSGVPSMGSALSPSNMNAIQSAQQASMNSLSYSSMNSGMSPMGYGATNINRTRDSKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFIKVSRSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKTQGGKGNQDGRKDHSGPSSPLHRVHGKSSQMDSSSSMSNPSSSPQALEHNGSNGEMKPQVAAGPSPLSSHQNHSTHSLAHETHIHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQQYSSYGGGLQGMPLGSPSMTGRGTIEPSALEPTYYQGVYSRPVLNTS UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.1180	Xl.68948 [+] Xl.9710		Xl.52787
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		107 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	FOXA1
mouse		MGI	Foxa1	All(6) Targeted, other(5) Targeted, knock Out(1)
zebrafish		ZFIN	foxa1

Publications
First:		Liver specific transcription factors of the HNF3-, C/EBP- and LFB1-families interact with the A-activator binding site. [Nucleic Acids Res 1991]
Most recent:		FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide™). [Mol Cell Endocrinol 2013]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Forkhead/HNF-3-related transcription factor (alt_id KOG:3563)

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.1180.1.S1_at [+] Str.1180.1.S2_at			Xl.888.1.S1_at
Affymetrix 2.0			Xl2.52787.2.A1_at [+] Xl2.52787.1.S1_at Xl2.9710.1.S1_at		Xl2.888.1.S1_at

Symbol legend[+]