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Summary Expression Gene Literature (481) GO Terms (10) Nucleotides (97) Proteins (29) Interactants (1451) Wiki
XB-GENEPAGE- 487723

Gene Symbol: nog

Gene Name: noggin

Synonyms: nog-A , noggin 1 , noggin , nog1 , noggin-1 , Noggin1
Add Xenopus synonyms , Nomenclature history


Gene Function: extracellular BMP antagonist

Protein Function :
Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface recepto...[+]


Interactants: Loading ...

Disease Ontology:
   PROXIMAL SYMPHALANGISM [+]

OMIM Diseases:
   SYMPHALANGISM, PROXIMAL, 1A; SYM1A [+]
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Xenbase Gene ID XB-GENE-487724 XB-GENE-864891 XB-GENE-17332089
Gene Symbol nog nog.L nog.S
Chromosome Chr10 chr9_10L Scaffold27
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.29004 Xl.834
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 36 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine nog nog.L nog.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NOG OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Nog MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR nog1 ZFIN Ensembl
chicken
GEISHA NOG Ensembl
fruit fly
worm
WORMBASE
Publications
First: Dissecting Wnt signalling pathways and Wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis. [Dev Suppl 1992]
Most recent: Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis. [Dev Biol 2018]
View All Papers 83 paper(s) referencing morpholinos 9 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 6 terms 0 term
PANTHER nog
KEGG Pathways K04658 K04658
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Nog Ab1 Nog Ab1
Morpholino nog MO1 , nog MO2 nog MO1 , nog MO2 nog MO1 , nog MO2
Affymetrix 1.0 Str.29004.1.S1_at Xl.834.1.S1_at
Affymetrix 2.0 Xl2.834.1.A1_at

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556