Gene Symbol: casp8 Gene Name: caspase 8, apoptosis-related cysteine peptidase Synonyms: xCaspase-8, caspase-8, xcaspase 8, caspase 8 Add Xenopus synonyms Gene Function: apoptotic cysteine protease Interactants: fas(5) , bcl2(3) , casp3(3) , fadd(3) , amd1(2) , casp2(2) , casp9(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002936540|PREDICTED: Xenopus (Silurana) tropicalis caspase-8-like (LOC100495471), mRNA ATGAGCAACCATTTAAGTTCTACAGTGGTTACCATGAATCCATCAGACGTGCATAAACTGCTGTATGATATAAGCGAGGATCTAGACAAAACTGAAACCCTTGAAATGATTTTCCTTTGTGAGAAGCGCATTACTGCCCAAGAGAAAGAGAATATCACAGATGCAAAGACATTATTCTCATATCTTCAAAGGAAAGATTGTATAAGTGGTGACAACCTGTCCTTCTTGAAAGAGTTACTCTACAGAATTGGTAGAAACGACCTACTCAGAGAAAAATTAGGAGTTAGAACAGAAGATATGAAGCAGCTTATTGAAATATCTGCACAAATTTCTCCATACAGGATTTTACTTCATGACATTTCACAAGGTCTTTCTAAAAAACAAGTGGATGATTTGAAATACTTGCTGAATCTAAGCACAGCCAAAACAGAAAATGCTCCTATACTGGACATATTCTTGGAACTGGAGAAGGTTGGAAAATTAAGCCCTGAAGACCTACAGGTGCTAAAATACAATTTAGAAGCAATTGGATGTAAAAACCTTTCCAAGAACATTGAAGACTTTGAAAGAGCATCAGAAGCTGATAATAAAGGCTTAGAAAGCCTACCAGATTTAATTGAGAAGATTTCAATACAAGAGGAGCAGTCTAACATGACTGTACAAGAAGCTTCCACTGGTCAACCAAGGTTACCCCAGGCAGAAACTGAAAGTGACTCTGGAAGACCTCAACAACACACTCATATAAATTTAGAAACCTACCGCTTGGAGAAACAACCTCATGGCTGGTGTGTGGTCATTAATAATTATGACTTCAGAGAGGCAAGGTCTCGGGATTGTAAATACAGTAACAGAGAAGGAACAATGAAAGATGCAGAGGATATTACAAAGATATTTAATGAACGTGGCTACATCACAGAGGAGCACAAAGATCTAACTGCTGAAAACATACGGAAAACCTTGGAGATGTATAGTAAGAAGGATCATGCAGAGAATGACAGCTTTGTGTGCTTTATTCTATCTCATGGAGGGATAGGAACTGTATGTGGCTGTGATGGGGAAGAGGTAGAAATCAAAAGACTGACAAAATATTTTAATGGGCAACACTGCCCCTCCCTTATCAATAAACCAAAGATTTTCTTCATCCAAGCTTGCCAGGGGAAAGAGTCACATCCAAAAGTTGATATTAATACAGATACTGAATCGCCTTTTTCTTTTTATGAACAAGATGCAATGGGAACTCATCTACCCCTAGAAGCAGACTTTTTAACCGCATTTGCAACAGTTGAAGAATATACATCTCTAAGGCACATAGAAAAAGGAAGCATTTATATTCAGCAACTGTGCAAGGCATTGACAACACATTTATGTCAAGACTTGATTGACATGCTAACCTTTGTTAATAATGAAGTTGCGGGTATGCTGTTCCCTTTAGGGAGGAAGAATGTGACACAGATGCCATCGTTTAAATCAGAGTTACGCAAAAAACTCGTTCTGCCGCCTCCCGATGCCACTCAGTTTAGATAA	Refseq >NM_001085565|Xenopus laevis caspase 8, apoptosis-related cysteine peptidase (casp8), mRNA ATGAGTGACCTGTTAAGTTCTACAGTGGATGCAATGAATCTGGCAGACATGAATAAACTGCTGTTTGAAATAAGTGAGGATCTGGACAAAACAGAAACCCTTGCAATGATTTTCCTTTGTGAGAAGCGCGTTACTGCCCAAGAAAAAGAAAACATCAAAGATGCAAAGACATTGTTCCTGTGTCTCAAAAAGAAAGATTTAATATGTTATAACGATCTGTCCTTCTTGAAAGAGTTACTCTACAGAATTGGTAGAAACGACCTACTCAGAGGCAAATTAGGGGTTAGAACAGAAGAAATTAAAAGAATTATTGAAGTATCTCCACAAATTTCTCCATACAGGATTTTACTTTATGACATTTCACAAGGTCTTTCTAAAAAAGAAGTCGAAGATTTGAAATACTTGCTGGATCTGAGCACAGCCAAAACAGAAAACGCTTCTATACTGGAAATATTCTTGGAACTGGAAAAAGTTGGAAAATTACATCCCGATGATCTACAGAAGCTAAAACACGATTTAGAAACAATTGGTTGTAAAAACCTTTCTAGGAACATTGAAGACTATGAAAGAATATCAGAAGCTGATAATCACAGGCCAGAAAACCTACCAGATTTATTTGAGAAGATTTCAGTACAAGAGGAGCAGGTTAATTGTACTGCACAAGAACCCTTCAATGGGGAGCAAAGGACACCCCAGCCTGAAACTGAAAGTGACTATTGCCAACCCCAACAACACTCTCATATGAATTTAGAGACCTACCACTTGGAGAAAAATCCTCATGGCTGGTGTGTGGTCATAAATAATTACGACTTCAAAGAGGCAAGGTCTCAGGATTGTAAATATACTGACAGAGAAGGAACAGCGAAGGATGCAGAGGAGATTACAAGGATATTTAATGCCCGGGGCTACATCACAGAAGAGCACAGGGATCTAACTGCTGCAAATATACAGAAAACCTTGGAGATGTATAGTAAGAAAGATCATGCAGAGAAAGACAGCTTTGTGTGCTTTATCCTCTCTCATGGTGGGGTAGGAACTGTATGTGGCTGTGACGGAGAAGAGGTGGAAATCAAGAGATTGACAAAATATTTTAATGGTCAACACTGTCGCTCTCTCATTAATAAACCAAAGATTTTCTTCATCCAAGCTTGTCAGGGGAAAGAATCACATCCAAAAGTTGATATGGATATGGATACTTCTTTTTATGAACCAGATGCAAATGGAAGTCATCTACCCCTAGAAGCAGACTTTTTAACCGCATTTGCGACAGTTGAAGATTATACAAGTCTAAGACATAGAGAAAACGGTAGCATTTATATTCAGCAACTGTGCAAGGCCTTGACAACTTACACAAATCAAGACCTGATCGATATACTAACCAGTGTTAATAGTGACGTTGCAAACATGCTGTTCCGTTTATGGAGGAAGAATGTAACACAGATGCCCTCATTTAAATCAGAGTTACGCAAAAAACTTATTCTGCCACCTCCTAATGCCATGTAA
Protein		NCBI Protein >XP_002936586|PREDICTED: caspase-8-like [Xenopus (Silurana) tropicalis] MSNHLSSTVVTMNPSDVHKLLYDISEDLDKTETLEMIFLCEKRITAQEKENITDAKTLFSYLQRKDCISGDNLSFLKELLYRIGRNDLLREKLGVRTEDMKQLIEISAQISPYRILLHDISQGLSKKQVDDLKYLLNLSTAKTENAPILDIFLELEKVGKLSPEDLQVLKYNLEAIGCKNLSKNIEDFERASEADNKGLESLPDLIEKISIQEEQSNMTVQEASTGQPRLPQAETESDSGRPQQHTHINLETYRLEKQPHGWCVVINNYDFREARSRDCKYSNREGTMKDAEDITKIFNERGYITEEHKDLTAENIRKTLEMYSKKDHAENDSFVCFILSHGGIGTVCGCDGEEVEIKRLTKYFNGQHCPSLINKPKIFFIQACQGKESHPKVDINTDTESPFSFYEQDAMGTHLPLEADFLTAFATVEEYTSLRHIEKGSIYIQQLCKALTTHLCQDLIDMLTFVNNEVAGMLFPLGRKNVTQMPSFKSELRKKLVLPPPDATQFR	Refseq >NP_001079034|caspase 8, apoptosis-related cysteine peptidase [Xenopus laevis] MSDLLSSTVDAMNLADMNKLLFEISEDLDKTETLAMIFLCEKRVTAQEKENIKDAKTLFLCLKKKDLICYNDLSFLKELLYRIGRNDLLRGKLGVRTEEIKRIIEVSPQISPYRILLYDISQGLSKKEVEDLKYLLDLSTAKTENASILEIFLELEKVGKLHPDDLQKLKHDLETIGCKNLSRNIEDYERISEADNHRPENLPDLFEKISVQEEQVNCTAQEPFNGEQRTPQPETESDYCQPQQHSHMNLETYHLEKNPHGWCVVINNYDFKEARSQDCKYTDREGTAKDAEEITRIFNARGYITEEHRDLTAANIQKTLEMYSKKDHAEKDSFVCFILSHGGVGTVCGCDGEEVEIKRLTKYFNGQHCRSLINKPKIFFIQACQGKESHPKVDMDMDTSFYEPDANGSHLPLEADFLTAFATVEDYTSLRHRENGSIYIQQLCKALTTYTNQDLIDILTSVNSDVANMLFRLWRKNVTQMPSFKSELRKKLILPPPNAM

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.979
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CASP8	OMIM:114550 OMIM:114480 OMIM:607271 OMIM:211980
mouse		MGI	Casp8	All(9) Targeted, knock Out(3) Targeted, other(6)
zebrafish		ZFIN	casp8

Publications
First:		Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. [J Biol Chem 1998]
Most recent:		FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. [Dev Biol 2010]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		caspase activity cathepsin F activity cysteine-type endopeptidase activity More[+] protein binding
Biological:		proteolysis regulation of apoptosis
Cellular Component:
EC:		Cysteine endopeptidases
KOG:		[D] Caspase, apoptotic cysteine protease

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.2793.1.S1_at	Xl.979.1.S1_at
Affymetrix 2.0			Xl2.979.1.S1_at

Symbol legend[+]

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