Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (98) GO Terms (28) Nucleotides (434) Proteins (54) Interactants (1288) Wiki
Gene Symbol:

Gene Name:
hes family bHLH transcription factor 4

Xhairy2 , hairy2 , hairy2b , Xhairy2b , hairy2a , XHairy2a , hes4a , hes4b , H2 , hes4-a , hes4-b ( Add synonyms , Nomenclature history )

Gene Function:
helix-loop-helix transcription factor/transcriptional repressor

Protein Function :
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Plays a role in the patterning of tissue boundaries. Promotes floor plate development and prechordal plate development. Required for ...[+]

Loading ...


External Links:
Xenbase Gene ID XB-GENE-487830 XB-GENE-865740 XB-GENE-6256031
Gene Symbol hes4 hes4.L hes4.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 394465
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hes4 hes4.L hes4.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards HES4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
fruit fly
First Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate., Genes Dev 1994          
Most Recent Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development., Environ Pollut 2020  
All View All Papers 18 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 25 terms 19 terms 13 terms
KEGG Pathways K06054 K06054 K06054
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hes4
Morpholinos hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5
ORFs hes4.L ORF1 hes4.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.16.0
Major funding for Xenbase is provided by grant P41 HD064556