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Summary Expression Gene Literature (238) GO Terms (29) Nucleotides (116) Proteins (47) Interactants (919) Wiki
XB-GENEPAGE-487965
Gene Symbol:
nkx2-5

Gene Name:
NK2 homeobox 5

Synonyms:
tinman , csx , XNkx-2.5 , Nkx-2.5 , nkx2.5 , XNkx2-5 , nkx-2.5 , AR2 , nkx2-5-a , nkx2-5-b ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor with role in cardiac development

Protein Function :
Implicated in commitment to and/or differentiation of the myocardial lineage. May regulate the expression of genes involved in cardiogenesis and play a role in the formation of gut and the pharyngeal r...[+]


InterPro :
Homeobox dom , NKX-2.5 , Homeobox metazoa , Homeobox CS [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
atrial heart septal defect 7 [+]

OMIM:
CONOTRUNCAL HEART MALFORMATIONS; CTHM [+]

External Links:
1/6
 
Xenbase Gene ID XB-GENE-487966 XB-GENE-6464336 XB-GENE-865753
Gene Symbol nkx2-5 nkx2-5.L nkx2-5.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100144646
100337581
379882
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nkx2-5 nkx2-5.L nkx2-5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NKX2-5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nkx2-5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nkx2-5 Ensembl
zebrafish
ZFIN, AGR nkx2.5 ZFIN Ensembl
chicken
GEISHA NKX2-5 Ensembl
fruit fly
worm
Publications
First XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development., Dev Biol 1994    
Most Recent Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism., Horm Res Paediatr 2020  
All View All Papers 40 paper(s) referencing morpholinos 7 paper(s) referencing OMIMs 10 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 26 terms 10 terms 13 terms
PANTHER nkx2-5
KEGG Pathways K09345 K09345 K09345
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nkx2-5
Transgenes Tg(nkx2.5:GFP) Tg(nkx2.5:GFP) Tg(nkx2.5:GFP)
Morpholinos nkx2-5 MO1 nkx2-5 MO1 nkx2-5 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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