nkx2-5 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (200)

Nucleotides (94)

Interactants (366)

XB-GENEPAGE-487965

Gene Symbol: nkx2-5 Gene Name: NK2 homeobox 5 Synonyms: tinman, csx, XNkx-2.5, Nkx-2.5, nkx2.5, XNkx2-5, nkx-2.5 Add Xenopus synonyms Gene Function: homeodomain transcription factor with role in cardiac development Interactants: gata4(44) , tbx5(29) , tnni3(20) , bmp4(18) , nppa(17) , frzb2(15) , nkx2-3(15) View All	1/4

XB-GENE-487966

XB-GENE-6464336

XB-GENE-865753

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001123419\|Xenopus (Silurana) tropicalis NK2 homeobox 5 (nkx2-5), mRNA CTGTCTCTCTATAAGTCTGGGGAGGTTACATGACTTTGTTTGGGGGGTTTACCTGGTGCCACCATGTTTGCCAGCCCTGTGACTTCCACTCCATTCTCTGTAAAGGACATTTTGAACTTGGAGCAACACCAGAGTGGACTGTCTCCAATGGACATCACTTCCAGGCTGGAGAACTCGTCCTGCATGCTATCCACCTTTAAACAGGAGCCCTACCCAGGGACCCCATGCCTCTCTGAACTCACTGAGGAACTTGCCCAGAGAGACTCCTCTAAGGGCCCCTCACCTTTTCCCGGATCGTTCTTTGTTAAGAATTATTTGGAAATGGACTCCTCTAAAGACCCCAAAGATGACAAGAAAGATATCTGCCCCCTGCAAAAAACATTGGAACATGACAAGAGAGAAGCTGAAGACCCAGAAAGACCAAGGCAAAGGAAGAGAAGGAAGCCCCGGGTTCTATTCTCCCAAGCCCAGGTGTATGAGCTAGAGAGAAGGTTCAAGCAGCAGAAGTATCTGTCAGCCCCAGAGAGGGACCATTTAGCCAATGTCCTGAAGCTCACATCCACACAGGTGAAAATTTGGTTCCAAAACAGAAGGTACAAATGCAAACGGCAGAGGCAAGATCAGACTCTGGAGATGGTCGGGCTACCACCGCCAAGAAGGATAGCTGTACCAGTTCTGGTGAGAGATGGGAAGCCTTGCTTGGGAGAGTCTTCACCTTACAATTCCCCTTATAATGTCAGTATCAACCCATACAGTTACAACACTTACCCTGCCTACTCCAACTACAGTAACCCTGCTTGTAGCGGAAGTTATAATTGCAGTTACTCTTCCATGCCTAGCATGCAGCCCACATCAGCTGGTAATAACTTTATGAATTTCAGCGTGGGGGACTTGAACACAGTGCAGACTCCAATCCAACAGGCTAGTGGTGTATCTGCACTTCATCATGGCATACGGGCTTGGTAGACTGTGGCCTAGAACCTTTATCAGAGCACTCAACAAAAAGGTGGCATTGACTGCAAGGACTGGAAATGGGTTGCAGGGATTTGTGGGGAGCAAAAATGTTCTGCACTCAATCAGTGCTAGATGTGTGGCCCATTAGAGCTACAGTTGGGTGTGTGTGGATAATATGAAATATGCCACGCTCAGATATCTGCTGAAGCACTGATGCAATATTCAGACACTTCTAATCCAGTTATTTCATGTAGTGTTCAGTTTTAGCAGCACCAAGGTATTTACAGGTTATCCAAGTGTGTGCGTCTATGTATTAATCCCTTTGCTGCAGGATCCCAGAGTCGCCCTGAAGATACAAAGCAGCATGCTAAAGACAATGGTTTGAATATTAAACTTATACGGAAAACTGTAAAGCCTCCAAATTCAATGGTATTTGCAAAATTAGACAGAAAATACATCTCATGTGCAGCCGGGAAATATTCATACTGATTTATTACTTATTAATGAAAGTGGAAACAAATGTGTTCTCATTGTTGCAGCCCACTCATTGCTATGTTTGTAGATAGCCCTACCCCAGACTGTGTTTCCTTAACCCCATAACTACCCAATAATTATACTTTTTTGTCACCCGAAAACTTTTAGAAAAAGCAATGCCAAATTATTATTATTATTTTTTAATTTAAAAGCTGTACATGTACAGCTCCTGGAAAACAGCTTTATTTATTAAGTTCAACAGATATGAAATATCCCTGCATCTGAGGTACGTGCCTTATACAGCAGGCTGAGAAACTCGGCCCACAGAGTAAAGCGGACTTGGACATTTTGTACTATATTGTGTAACTTTAAAAGGCATGTAAAGCTCAACAAACTGTGTTGTTTTTTTCCTTCTTTGTTGTTTTGTTTTTATGCAACCAAAATGTTGTCAGACTACAGATCTAAGATAAATGTAATAAATCTGCTCACCAAAAAA	Refseq >NM_001172192\|Xenopus laevis NK2 homeobox 5 (nkx2-5-a), mRNA ATGTTTGCCAGTCCTGTGACTTCCACTCCATTCTCTGTAAAGGACATTTTGAATTTGGAGCAACACCAGAATGGATTGTCTCCAATGGACATCACTTCCAGGCTGGAGAACTCGGCCTGCATGCTGTCCAACTTTAAACAGGAGCCCTACCCTGGAACCCCATGCCTTTCTGAACTCACTGAGGAACTTTCCCAGAGAGACGCCTCTAAGGGCCCCTCGCCTTTCCCTGGATCATTCTTTGTTAAGAATTATTTGGAAATGGACTCCTCTAAAGCGCCCAAAGATGACAAGAAAGATATCTGCCCCCTGCAGAAAACTTTGGAACATGACAAAAGAGAGTCTGAAGACCCAGAAAGACCAAGACAAAGGAAGAGAAGGAAGCCTCGCGTGCTGTTCTCCCAAGCCCAGGTGTATGAGCTGGAGAGAAGGTTCAAGCAGCAGAAATATCTGTCAGCCCCAGAGAGGGACCATTTAGCCAATGTCCTGAAGCTCACCTCCACACAGGTGAAAATTTGGTTCCAAAACAGAAGGTACAAATGCAAACGGCAGCGGCAAGATCAGACTCTAGAGATGGTGGGGCTACCACCTCCAAGACGGATAGCTGTACCAGTCCTGGTAAGAGATGGGAAGCCTTGCTTGGGAGAGTCTTCTCCTTACAATTCCCCATATAATGTCAGCATCAACCCCTACAGCTACAACACTTACCCTGCCCACTCCAACTACAATAACCCAGCCTGTAGCGGAAGCTATAATTGCAGTTACTCTTCCATGCCTAGCATGCAGCCCACGTCCGCTGGTAATAACTTTATGAATTTCAGCGTGGGGGACTTGAACACAGTGCAGACTCCAATCCAACAGGCCAGCGGTGTATCTGCACTTCATCATGGCATCCGAGCTTGGTAG		Refseq >NM_001086721\|Xenopus laevis NK2 homeobox 5 (nkx2-5-b), mRNA GCTGGAATGAGATGGCTCTCCTTTGAAAAGCCCTGGGACCCAATCTCTCTCTCTGTGTCTATCCAAGTCTGGGGAGGTTACATGACTTTGTTTGGGGGGCTTACCTGGTACCATCATGTTTGCCAGTCCTGTGACATCCACTCCATTCTCTGTAAAGGACATTTTGAACTTGGAGCAACACCAGAGTGGATTGTCTCCAATGGACATCACTTCCAGGCTGGAGAACTCGTCCTGCATGCTGTCCACCTTTAAACAGGAGTCCTACCCTGGAACCCCTTGCCTCTCTGAACTCACTGAGGAAATGTCCCAGAGAGACACCTCTAAGGGCCCCTCGTCTTTCCCTGGATCGTTCTTTGTTAAGAATTATTTGGAAATGGACTCTAAAGATCCCAAAGATGACAAGAAAGATATCTGCCCCCTGCAAAAAACTTTAGAACACGACAAAAGAGAGGCTGAAGACCCAGAAAGACCAAGACAAAGGAAGAGAAGGAAGCCTCGGGTGCTGTTCTCCCAAGCCCAGGTGTATGAGCTGGAGAGAAGGTTCAAGCAGCAGAAGTATCTGTCAGCCCCTGAGAGGGACCATTTAGCCAATGTCCTGAAGCTCACCTCCACACAGGTGAAAATTTGGTTCCAAAACAGAAGGTACAAATGCAAACGGCAGAGGCAAGATCAGACTCTAGAAATGGTCGGGTTACCACCTCCACGAAGGATAGCTGTACCAGTCCTGGTGAGAGATGGGAAGCCTTGCTTGGGAGAGTCTTCTCCTTACAATTCCCCATACAATGTCAGCATCAACCCATACAGCTACAACACTTACCCTGCCTACTCCAACTACAGTAACCCAGCCTGTAGCGGAAGTTATAATTGCAGTTACTCTTCCATGCCTAGCATGCAGCCCACGTCAGCTGGTAATAACTTTATGAATTTTAGCGTGGGGGACTTGAACACAGTGCAGACTCCAATCCAACAGGCCAGCAGCGTATCTGCACTTCATCATGGCATCCGAGCTTGGTAGACTGCGGCCTAGAACTTTTATCAGAGCACTCAATTAAAAGAGGTGGCATTGACTGCAAGGACTGGAAATGGGTTGCAGGGATTTGTGGGAAGGAAAAATGTTCTGCACTCGCTCAGTGCTAGGAGTACAGCCCATTAGAGCTACAGTTGGGTGTGTGTGGTTAATATGGCAATATGCGACGGTCAGATGTCTACTGAAGCACTGATGCAATCAGACAGAGTTATTTCATGTAGTGTTCAGTTATAGCAGCACCAAGTTATTTACAGGTTATATGAGTGTGTGTGTGTGTGTGTCTGTGTATTAACCCCTACCCTGCAGGATCCCAAAGTTGCCCAACAGCATCCTACAGACAAAGTACTGAATATTAAACTTGTACTGATAATTCCAGAGACACTGAATGAGCACATACCTAGTCGCTTCACTCTGACGGTACTGGGAAAGGTTTCCCTGATCAAAATGATAACTGTAATTAAAAACAATACAGAAAATACATCTCGTGTGCAGCCGGGAACTATAAATACTGATTTGTTTCTTATTACTAAAGGTAGCAACAAATCTGTTCTAATTTTTATGCAACGCACAAATAATTGTAGATAGCCCTGCCCCAGACTTGTGTTTCTTCAACTCTATAAGAGTCCAGAAATGGTACATTTTTTTAGATAAGCAAAGCAAAATTATTATTGTTTTTAATTTAAAAGCTGTACTGTATATGTACAGCTCCTGCAAAACAGCTTTATTTATTCAGTTTAATAGATATTGAATATCCCTGCATCTGACATACCTGTATGTGCCTTATACTGCCAGTTTAGAAACTGCAAAACAATGCAAGTGACATTTTGTACTATATTGTGTAACTGCAAAAGGCATGTAGCGCTCAACAAAATCTGCTTTTTTTTTTCCTTCTTCTTTGTTGATCTTTTTCTGCAACCAAAATGTCGTCAGACTACAGATCTAAGATAAATGTAATAAATCTGCTCACCAAGTTTGTTGCATGTCATTTAACCAATATATGAAATGAGTTACAAAATGCATGGCAGAGGGATGGACCAACTGCAACAGAACTTGCACCATGATCTCTCATCATTATCAGTCATTTTTATATTTATTGAAGGGAGTTTTTTGAAGTAGTCATTGTATTGCACTTCAGATGACTTTATCATGTTCACATATGCTAAAGGGTGAATTACGTTGGTTGATACTTATTATTGTCTTATCAGCAGTAGATAAAAAAAATAGTTTCATCCTATTTGGCAATAACACTGATTTCAACATTTTTGTGACCTGGAGACTCCAGCTAATTCACATACGTTTTGAAGGGTCCAATTGCTGAAGGCCTATATGTATTTAAGAAAAGAATTGCTTATGCAGGTATGGGACCTGTTTTTCAGAAGGCTCAGGTCCTGGGGTTTTCCAGATAAGGCATCTTTCAAGAATTTGGATCACCATATTTTGTTTACTAAAAAATAATTAAAACATTAAAAAAAAAAAAAA
Protein		Refseq >NP_001116891\|NK2 homeobox 5 [Xenopus (Silurana) tropicalis] MFASPVTSTPFSVKDILNLEQHQSGLSPMDITSRLENSSCMLSTFKQEPYPGTPCLSELTEELAQRDSSKGPSPFPGSFFVKNYLEMDSSKDPKDDKKDICPLQKTLEHDKREAEDPERPRQRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAYSNYSNPACSGSYNCSYSSMPSMQPTSAGNNFMNFSVGDLNTVQTPIQQASGVSALHHGIRAW	Refseq >NP_001165663\|NK2 homeobox 5 [Xenopus laevis] MFASPVTSTPFSVKDILNLEQHQNGLSPMDITSRLENSACMLSNFKQEPYPGTPCLSELTEELSQRDASKGPSPFPGSFFVKNYLEMDSSKAPKDDKKDICPLQKTLEHDKRESEDPERPRQRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAHSNYNNPACSGSYNCSYSSMPSMQPTSAGNNFMNFSVGDLNTVQTPIQQASGVSALHHGIRAW		Refseq >NP_001080190\|homeobox protein Nkx-2.5 [Xenopus laevis] MFASPVTSTPFSVKDILNLEQHQSGLSPMDITSRLENSSCMLSTFKQESYPGTPCLSELTEEMSQRDTSKGPSSFPGSFFVKNYLEMDSKDPKDDKKDICPLQKTLEHDKREAEDPERPRQRKRRKPRVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKRQRQDQTLEMVGLPPPRRIAVPVLVRDGKPCLGESSPYNSPYNVSINPYSYNTYPAYSNYSNPACSGSYNCSYSSMPSMQPTSAGNNFMNFSVGDLNTVQTPIQQASSVSALHHGIRAW UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.38922	Xl.48440		Xl.22859
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		123 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NKX2-5	OMIM:187500 OMIM:108900 OMIM:225250
mouse		MGI	Nkx2-5	All(13) Targeted, knock Out(1) Targeted, other(10)
zebrafish		ZFIN	nkx2.5

Publications
First:		XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. [Dev Biol 1994]
Most recent:		Tcf21 regulates the specification and maturation of proepicardial cells. [Development 2013]
		View All Papers 21 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor tinman/NKX2-3, contains HOX domain

Reagents		tropicalis	laevis a		laevis b
Clones		EXRC - 1 clone(s)	EXRC - 1 clone(s)		EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.38922.1.A1_at			Xl.1093.1.S1_at [+] Xl.22859.1.A1_at
Affymetrix 2.0			Xl2.48440.1.S1_s_at		Xl2.1093.1.S1_at [+] Xl2.22859.1.A1_at

Symbol legend[+]