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Summary Expression Gene Literature (7) GO Terms (17) Nucleotides (94) Proteins (45) Interactants (246) Wiki
XB-GENEPAGE-488766
Gene Symbol:
hdac4

Gene Name:
histone deacetylase 4

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
regulation of gene expression

Protein Function :
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an importan...[+]



Interactants:
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Diseases: 


Disease Ontology:
chromosome 2q37 deletion syndrome

OMIM:
CHROMOSOME 2q37 DELETION SYNDROME

External Links:
 
Xenbase Gene ID XB-GENE-488767 XB-GENE-17335610 XB-GENE-6486313
Gene Symbol hdac4 hdac4.L hdac4.S
Chromosome Chr9 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100489340
108701411
108703026
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hdac4 hdac4.L hdac4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards HDAC4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Hdac4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Hdac4 Ensembl
zebrafish
ZFIN, AGR hdac4 ZFIN Ensembl
chicken
GEISHA HDAC4 Ensembl
fruit fly
FLYBASE HDAC4 Ensembl
worm
Publications
First A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation., Mol Cell 2010                
Most Recent Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma., Mol Cancer Res 2021  
All View All Papers 3 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 0 term 5 terms
PANTHER hdac4
KEGG Pathways K11406 K11406
KOG [B] Histone deacetylase complex, catalytic component HDA1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hdac4
Clones Horizon Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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