Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (333) GO Terms (9) Nucleotides (248) Proteins (39) Interactants (1748) Wiki
XB-GENEPAGE-491120
Gene Symbol:
tubb2b

Gene Name:
tubulin beta 2B class IIb

Synonyms:
n-tubulin , ntubulin , Xn-tubulin , N-Tub , neural beta-tubulin , NBT , NST ( Add synonyms , Nomenclature history )

Gene Function:
microtubule component

Protein Function :
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


InterPro :
TIMP-like OB-fold , Complement C5 , MG4 , C3/4/5 MG1 [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
cerebellar ataxia, mental retardation and dysequlibrium syndrome [+]

OMIM:
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 7; CDCBM7

External Links:
1/4
 
Xenbase Gene ID XB-GENE-491121 XB-GENE-17340462 XB-GENE-866032
Gene Symbol tubb2b tubb2b.L tubb2b.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 394889
108719115
379220
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tubb2b tubb2b.L tubb2b.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards TUBB2B OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tubb2b MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tubb2b Ensembl
zebrafish
ZFIN, AGR tubb2b ZFIN Ensembl
chicken
GEISHA TUBB2B Ensembl
fruit fly
Publications
First Gene expression in the embryonic nervous system of Xenopus laevis., Proc Natl Acad Sci U S A 1988        
Most Recent Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly., Genome Med 2021              
All View All Papers 91 paper(s) referencing morpholinos 11 paper(s) referencing OMIMs 19 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 6 terms 6 terms
PANTHER tubb2b
KEGG Pathways K07375 K07375 K07375
KOG [Z] Beta tubulin
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tubb2b
Antibodies Tubb2b Ab1 , Tubb2b Ab2 , Tubb2b Ab3 , Tubb2b Ab4 , Tubb2b Ab5 , Tubb2b Ab6 , Tubb2b Ab8 Tubb2b Ab6 , Tubb2b Ab8 Tubb2b Ab1 , Tubb2b Ab2 , Tubb2b Ab3 , Tubb2b Ab4 , Tubb2b Ab5 , Tubb2b Ab6 , Tubb2b Ab8
ORFs tubb2b ORF1 tubb2b.S ORF1
Clones EXRC Horizon Source BioScience Horizon EXRC Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info